ID   TLE5_HUMAN              Reviewed;         197 AA.
AC   Q08117; B2RBL0; Q12808; Q14CJ1; Q96TG9; Q9UDY9;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2002, sequence version 4.
DT   27-MAR-2024, entry version 206.
DE   RecName: Full=TLE family member 5 {ECO:0000305};
DE   AltName: Full=Amino-terminal enhancer of split;
DE            Short=Amino enhancer of split;
DE   AltName: Full=Gp130-associated protein GAM;
DE   AltName: Full=Grg-5;
DE   AltName: Full=Groucho-related protein 5;
DE   AltName: Full=Protein ESP1;
DE   AltName: Full=Protein GRG;
DE   AltName: Full=TLE family member 5, transcriptional modulator {ECO:0000305};
GN   Name=TLE5 {ECO:0000312|HGNC:HGNC:307}; Synonyms=AES, GRG, GRG5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Neuroblastoma;
RA   Scala L.A., Piparo K.E., Tirumalai P.S., Howells R.D.;
RT   "Molecular cloning, sequence analysis and characterization of a human
RT   homolog of Drosophila enhancer of split m9/m10.";
RL   Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Lymphocyte, and Umbilical cord;
RX   PubMed=9809752; DOI=10.1089/dna.1998.17.911;
RA   Hou E.W., Li S.S.-L.;
RT   "Genomic organization and chromosome localization to band 19p13.3 of the
RT   human AES gene: gene product exhibits strong similarity to the N-terminal
RT   domain of Drosophila enhancer of split Groucho protein.";
RL   DNA Cell Biol. 17:911-913(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RA   Liu Y., Jin B.Q., Liu F.;
RT   "Cloning and eukaryotic expressing of a novel gp130 associated molecule.";
RL   Zhonghua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi 18:106-110(1998).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Amygdala, and Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 13-197 (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RX   PubMed=8365415; DOI=10.1111/j.1432-1033.1993.tb18151.x;
RA   Miyasaka H., Choudhury B.K., Hou E.W., Li S.S.-L.;
RT   "Molecular cloning and expression of mouse and human cDNA encoding AES and
RT   ESG proteins with strong similarity to Drosophila enhancer of split groucho
RT   protein.";
RL   Eur. J. Biochem. 216:343-352(1993).
RN   [9]
RP   FUNCTION, AND INTERACTION WITH RELA.
RX   PubMed=10660609; DOI=10.1074/jbc.275.6.4383;
RA   Tetsuka T., Uranishi H., Imai H., Ono T., Sonta S., Takahashi N.,
RA   Asamitsu K., Okamoto T.;
RT   "Inhibition of nuclear factor-kappaB-mediated transcription by association
RT   with the amino-terminal enhancer of split, a Groucho-related protein
RT   lacking WD40 repeats.";
RL   J. Biol. Chem. 275:4383-4390(2000).
RN   [10]
RP   FUNCTION, AND OLIGOMERIZATION.
RX   PubMed=10748198; DOI=10.1074/jbc.m910211199;
RA   Wang J.-C., Waltner-Law M., Yamada K., Osawa H., Stifani S., Granner D.K.;
RT   "Transducin-like enhancer of split proteins, the human homologs of
RT   Drosophila groucho, interact with hepatic nuclear factor 3beta.";
RL   J. Biol. Chem. 275:18418-18423(2000).
RN   [11]
RP   INTERACTION WITH PHF12.
RX   PubMed=11390640; DOI=10.1128/mcb.21.13.4110-4118.2001;
RA   Yochum G.S., Ayer D.E.;
RT   "Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the
RT   mSin3A-histone deacetylase complex.";
RL   Mol. Cell. Biol. 21:4110-4118(2001).
RN   [12]
RP   INTERACTION WITH SIX3.
RX   PubMed=12441302; DOI=10.1242/dev.00185;
RA   Lopez-Rios J., Tessmar K., Loosli F., Wittbrodt J., Bovolenta P.;
RT   "Six3 and Six6 activity is modulated by members of the groucho family.";
RL   Development 130:185-195(2003).
RN   [13]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [14]
RP   UBIQUITINATION BY XIAP/BIRC4.
RX   PubMed=22304967; DOI=10.1016/j.molcel.2011.12.032;
RA   Hanson A.J., Wallace H.A., Freeman T.J., Beauchamp R.D., Lee L.A., Lee E.;
RT   "XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.";
RL   Mol. Cell 45:619-628(2012).
CC   -!- FUNCTION: Transcriptional corepressor. Acts as a dominant repressor
CC       towards other family members. Inhibits NF-kappa-B-regulated gene
CC       expression. May be required for the initiation and maintenance of the
CC       differentiated state. Essential for the transcriptional repressor
CC       activity of SIX3 during retina and lens development.
CC       {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}.
CC   -!- SUBUNIT: Homooligomer and heterooligomer with other family members.
CC       Binds TCF7 (By similarity). Binds the NF-kappa-B subunit RELA.
CC       Interacts with PHF12. Interacts (via Q domain) with SIX3. Interacts
CC       with SIX6. {ECO:0000250, ECO:0000269|PubMed:10660609,
CC       ECO:0000269|PubMed:11390640, ECO:0000269|PubMed:12441302}.
CC   -!- INTERACTION:
CC       Q08117; Q9NYB9: ABI2; NbExp=5; IntAct=EBI-717810, EBI-743598;
CC       Q08117; Q8WTP8: AEN; NbExp=3; IntAct=EBI-717810, EBI-8637627;
CC       Q08117; Q9NX04: AIRIM; NbExp=3; IntAct=EBI-717810, EBI-8643161;
CC       Q08117; A7KAX9: ARHGAP32; NbExp=3; IntAct=EBI-717810, EBI-308663;
CC       Q08117; P54253: ATXN1; NbExp=3; IntAct=EBI-717810, EBI-930964;
CC       Q08117; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-717810, EBI-742750;
CC       Q08117; P41182: BCL6; NbExp=3; IntAct=EBI-717810, EBI-765407;
CC       Q08117; O14503: BHLHE40; NbExp=3; IntAct=EBI-717810, EBI-711810;
CC       Q08117; Q96CA5: BIRC7; NbExp=4; IntAct=EBI-717810, EBI-517623;
CC       Q08117; Q13895: BYSL; NbExp=5; IntAct=EBI-717810, EBI-358049;
CC       Q08117; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-717810, EBI-747505;
CC       Q08117; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-717810, EBI-946029;
CC       Q08117; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-717810, EBI-739580;
CC       Q08117; Q9H257: CARD9; NbExp=4; IntAct=EBI-717810, EBI-751319;
CC       Q08117; Q2TAC2: CCDC57; NbExp=3; IntAct=EBI-717810, EBI-2808286;
CC       Q08117; Q8IV13: CCNJL; NbExp=3; IntAct=EBI-717810, EBI-21668062;
CC       Q08117; O75909: CCNK; NbExp=3; IntAct=EBI-717810, EBI-739806;
CC       Q08117; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-717810, EBI-749051;
CC       Q08117; Q96Q77: CIB3; NbExp=3; IntAct=EBI-717810, EBI-10292696;
CC       Q08117; Q8N684: CPSF7; NbExp=3; IntAct=EBI-717810, EBI-746909;
CC       Q08117; Q9BSW2: CRACR2A; NbExp=4; IntAct=EBI-717810, EBI-739773;
CC       Q08117; O43186: CRX; NbExp=3; IntAct=EBI-717810, EBI-748171;
CC       Q08117; P26196: DDX6; NbExp=3; IntAct=EBI-717810, EBI-351257;
CC       Q08117; Q14689-6: DIP2A; NbExp=3; IntAct=EBI-717810, EBI-10233719;
CC       Q08117; Q96JC9: EAF1; NbExp=4; IntAct=EBI-717810, EBI-769261;
CC       Q08117; O60573: EIF4E2; NbExp=3; IntAct=EBI-717810, EBI-398610;
CC       Q08117; Q86V42: FAM124A; NbExp=3; IntAct=EBI-717810, EBI-744506;
CC       Q08117; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-717810, EBI-741626;
CC       Q08117; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-717810, EBI-10244131;
CC       Q08117; O15409: FOXP2; NbExp=3; IntAct=EBI-717810, EBI-983612;
CC       Q08117; O43559: FRS3; NbExp=3; IntAct=EBI-717810, EBI-725515;
CC       Q08117; A1L4K1: FSD2; NbExp=4; IntAct=EBI-717810, EBI-5661036;
CC       Q08117; P14136: GFAP; NbExp=3; IntAct=EBI-717810, EBI-744302;
CC       Q08117; Q08379: GOLGA2; NbExp=3; IntAct=EBI-717810, EBI-618309;
CC       Q08117; Q9H8Y8: GORASP2; NbExp=4; IntAct=EBI-717810, EBI-739467;
CC       Q08117; P62993: GRB2; NbExp=3; IntAct=EBI-717810, EBI-401755;
CC       Q08117; P52597: HNRNPF; NbExp=3; IntAct=EBI-717810, EBI-352986;
CC       Q08117; Q8IX15-3: HOMEZ; NbExp=3; IntAct=EBI-717810, EBI-10172004;
CC       Q08117; P42858: HTT; NbExp=3; IntAct=EBI-717810, EBI-466029;
CC       Q08117; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-717810, EBI-747204;
CC       Q08117; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-717810, EBI-2556193;
CC       Q08117; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-717810, EBI-2125614;
CC       Q08117; A1A4E9: KRT13; NbExp=3; IntAct=EBI-717810, EBI-10171552;
CC       Q08117; P19012: KRT15; NbExp=3; IntAct=EBI-717810, EBI-739566;
CC       Q08117; Q15323: KRT31; NbExp=3; IntAct=EBI-717810, EBI-948001;
CC       Q08117; Q6A162: KRT40; NbExp=3; IntAct=EBI-717810, EBI-10171697;
CC       Q08117; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-717810, EBI-10172290;
CC       Q08117; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-717810, EBI-10171774;
CC       Q08117; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-717810, EBI-10172052;
CC       Q08117; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-717810, EBI-739909;
CC       Q08117; O95751: LDOC1; NbExp=3; IntAct=EBI-717810, EBI-740738;
CC       Q08117; Q96FQ7: LINC00526; NbExp=3; IntAct=EBI-717810, EBI-10286106;
CC       Q08117; P25800: LMO1; NbExp=3; IntAct=EBI-717810, EBI-8639312;
CC       Q08117; P25791: LMO2; NbExp=3; IntAct=EBI-717810, EBI-739696;
CC       Q08117; P61968: LMO4; NbExp=3; IntAct=EBI-717810, EBI-2798728;
CC       Q08117; Q9Y333: LSM2; NbExp=3; IntAct=EBI-717810, EBI-347416;
CC       Q08117; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-717810, EBI-746778;
CC       Q08117; Q86VM6: MBNL1; NbExp=3; IntAct=EBI-717810, EBI-10225084;
CC       Q08117; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-717810, EBI-394607;
CC       Q08117; P55081: MFAP1; NbExp=3; IntAct=EBI-717810, EBI-1048159;
CC       Q08117; Q96PC5: MIA2; NbExp=3; IntAct=EBI-717810, EBI-1050253;
CC       Q08117; Q9UH92: MLX; NbExp=4; IntAct=EBI-717810, EBI-741109;
CC       Q08117; Q15014: MORF4L2; NbExp=3; IntAct=EBI-717810, EBI-399257;
CC       Q08117; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-717810, EBI-742948;
CC       Q08117; Q15742: NAB2; NbExp=3; IntAct=EBI-717810, EBI-8641936;
CC       Q08117; Q9UBB6: NCDN; NbExp=3; IntAct=EBI-717810, EBI-1053490;
CC       Q08117; Q9HC98: NEK6; NbExp=3; IntAct=EBI-717810, EBI-740364;
CC       Q08117; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-717810, EBI-945833;
CC       Q08117; Q9BRQ3: NUDT22; NbExp=4; IntAct=EBI-717810, EBI-10297093;
CC       Q08117; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-717810, EBI-10225049;
CC       Q08117; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-717810, EBI-9057006;
CC       Q08117; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-717810, EBI-3921217;
CC       Q08117; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-717810, EBI-710402;
CC       Q08117; Q13131: PRKAA1; NbExp=3; IntAct=EBI-717810, EBI-1181405;
CC       Q08117; P54646: PRKAA2; NbExp=3; IntAct=EBI-717810, EBI-1383852;
CC       Q08117; O75360: PROP1; NbExp=4; IntAct=EBI-717810, EBI-9027467;
CC       Q08117; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-717810, EBI-1567797;
CC       Q08117; P79522: PRR3; NbExp=3; IntAct=EBI-717810, EBI-2803328;
CC       Q08117; Q9Y3E5: PTRH2; NbExp=7; IntAct=EBI-717810, EBI-1056751;
CC       Q08117; P47897: QARS1; NbExp=3; IntAct=EBI-717810, EBI-347462;
CC       Q08117; P47897-2: QARS1; NbExp=3; IntAct=EBI-717810, EBI-10209725;
CC       Q08117; P98175: RBM10; NbExp=3; IntAct=EBI-717810, EBI-721525;
CC       Q08117; Q93062: RBPMS; NbExp=3; IntAct=EBI-717810, EBI-740322;
CC       Q08117; Q04864: REL; NbExp=3; IntAct=EBI-717810, EBI-307352;
CC       Q08117; Q8HWS3: RFX6; NbExp=3; IntAct=EBI-717810, EBI-746118;
CC       Q08117; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-717810, EBI-372094;
CC       Q08117; Q9UFD9: RIMBP3; NbExp=3; IntAct=EBI-717810, EBI-10182375;
CC       Q08117; Q96EP0-3: RNF31; NbExp=3; IntAct=EBI-717810, EBI-10225152;
CC       Q08117; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-717810, EBI-748391;
CC       Q08117; O00560: SDCBP; NbExp=3; IntAct=EBI-717810, EBI-727004;
CC       Q08117; Q15475: SIX1; NbExp=3; IntAct=EBI-717810, EBI-743675;
CC       Q08117; P12757: SKIL; NbExp=3; IntAct=EBI-717810, EBI-2902468;
CC       Q08117; P84022: SMAD3; NbExp=4; IntAct=EBI-717810, EBI-347161;
CC       Q08117; Q5TAL4: SNRPC; NbExp=3; IntAct=EBI-717810, EBI-10246938;
CC       Q08117; P35711: SOX5; NbExp=4; IntAct=EBI-717810, EBI-3505701;
CC       Q08117; P78362: SRPK2; NbExp=3; IntAct=EBI-717810, EBI-593303;
CC       Q08117; O75716: STK16; NbExp=3; IntAct=EBI-717810, EBI-749295;
CC       Q08117; O75558: STX11; NbExp=3; IntAct=EBI-717810, EBI-714135;
CC       Q08117; O15119: TBX3; NbExp=3; IntAct=EBI-717810, EBI-3452216;
CC       Q08117; P15884: TCF4; NbExp=3; IntAct=EBI-717810, EBI-533224;
CC       Q08117; Q13077: TRAF1; NbExp=3; IntAct=EBI-717810, EBI-359224;
CC       Q08117; Q12933: TRAF2; NbExp=3; IntAct=EBI-717810, EBI-355744;
CC       Q08117; Q12899: TRIM26; NbExp=3; IntAct=EBI-717810, EBI-2341136;
CC       Q08117; P14373: TRIM27; NbExp=4; IntAct=EBI-717810, EBI-719493;
CC       Q08117; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-717810, EBI-725997;
CC       Q08117; Q8IV54: TSC22D4; NbExp=3; IntAct=EBI-717810, EBI-10261521;
CC       Q08117; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-717810, EBI-744794;
CC       Q08117; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-717810, EBI-3918381;
CC       Q08117; P26368: U2AF2; NbExp=3; IntAct=EBI-717810, EBI-742339;
CC       Q08117; Q5T124: UBXN11; NbExp=3; IntAct=EBI-717810, EBI-746004;
CC       Q08117; Q9H9H4: VPS37B; NbExp=3; IntAct=EBI-717810, EBI-4400866;
CC       Q08117; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-717810, EBI-2559305;
CC       Q08117; O43167: ZBTB24; NbExp=3; IntAct=EBI-717810, EBI-744471;
CC       Q08117; Q8N5A5: ZGPAT; NbExp=4; IntAct=EBI-717810, EBI-3439227;
CC       Q08117; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-717810, EBI-10183064;
CC       Q08117; Q9H609: ZNF576; NbExp=3; IntAct=EBI-717810, EBI-3921014;
CC       Q08117; Q9H614; NbExp=3; IntAct=EBI-717810, EBI-10249899;
CC       Q08117-2; Q9NYB9-2: ABI2; NbExp=6; IntAct=EBI-11741437, EBI-11096309;
CC       Q08117-2; Q5BKX5-3: ACTMAP; NbExp=3; IntAct=EBI-11741437, EBI-11976299;
CC       Q08117-2; O95994: AGR2; NbExp=3; IntAct=EBI-11741437, EBI-712648;
CC       Q08117-2; Q9NX04: AIRIM; NbExp=3; IntAct=EBI-11741437, EBI-8643161;
CC       Q08117-2; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-11741437, EBI-357530;
CC       Q08117-2; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-11741437, EBI-12224467;
CC       Q08117-2; X5D778: ANKRD11; NbExp=3; IntAct=EBI-11741437, EBI-17183751;
CC       Q08117-2; Q9Y575-3: ASB3; NbExp=3; IntAct=EBI-11741437, EBI-14199987;
CC       Q08117-2; Q7L5A3: ATOSB; NbExp=3; IntAct=EBI-11741437, EBI-745689;
CC       Q08117-2; O95429: BAG4; NbExp=3; IntAct=EBI-11741437, EBI-2949658;
CC       Q08117-2; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-11741437, EBI-742750;
CC       Q08117-2; O14503: BHLHE40; NbExp=3; IntAct=EBI-11741437, EBI-711810;
CC       Q08117-2; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-11741437, EBI-517623;
CC       Q08117-2; Q9NP55: BPIFA1; NbExp=5; IntAct=EBI-11741437, EBI-953896;
CC       Q08117-2; Q13895: BYSL; NbExp=5; IntAct=EBI-11741437, EBI-358049;
CC       Q08117-2; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-11741437, EBI-12809220;
CC       Q08117-2; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-11741437, EBI-725606;
CC       Q08117-2; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-11741437, EBI-946029;
CC       Q08117-2; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-11741437, EBI-739879;
CC       Q08117-2; Q9NPB3: CABP2; NbExp=3; IntAct=EBI-11741437, EBI-12011224;
CC       Q08117-2; Q9NP86: CABP5; NbExp=5; IntAct=EBI-11741437, EBI-10311131;
CC       Q08117-2; Q96HB5: CCDC120; NbExp=6; IntAct=EBI-11741437, EBI-744556;
CC       Q08117-2; O75909-2: CCNK; NbExp=3; IntAct=EBI-11741437, EBI-12010594;
CC       Q08117-2; P22674: CCNO; NbExp=3; IntAct=EBI-11741437, EBI-2556878;
CC       Q08117-2; Q9H5F2: CFAP68; NbExp=3; IntAct=EBI-11741437, EBI-718615;
CC       Q08117-2; Q96Q77: CIB3; NbExp=3; IntAct=EBI-11741437, EBI-10292696;
CC       Q08117-2; O95833: CLIC3; NbExp=3; IntAct=EBI-11741437, EBI-10192241;
CC       Q08117-2; Q96DZ5: CLIP3; NbExp=3; IntAct=EBI-11741437, EBI-12823145;
CC       Q08117-2; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-11741437, EBI-12819063;
CC       Q08117-2; Q96BR5: COA7; NbExp=3; IntAct=EBI-11741437, EBI-6269632;
CC       Q08117-2; Q8N684-3: CPSF7; NbExp=3; IntAct=EBI-11741437, EBI-11523759;
CC       Q08117-2; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-11741437, EBI-739773;
CC       Q08117-2; O43186: CRX; NbExp=3; IntAct=EBI-11741437, EBI-748171;
CC       Q08117-2; P68400: CSNK2A1; NbExp=3; IntAct=EBI-11741437, EBI-347804;
CC       Q08117-2; P33240: CSTF2; NbExp=3; IntAct=EBI-11741437, EBI-711360;
CC       Q08117-2; Q9H0L4: CSTF2T; NbExp=6; IntAct=EBI-11741437, EBI-747012;
CC       Q08117-2; Q8WUE5: CT55; NbExp=3; IntAct=EBI-11741437, EBI-6873363;
CC       Q08117-2; P56545-3: CTBP2; NbExp=3; IntAct=EBI-11741437, EBI-10171902;
CC       Q08117-2; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11741437, EBI-3867333;
CC       Q08117-2; Q15038: DAZAP2; NbExp=3; IntAct=EBI-11741437, EBI-724310;
CC       Q08117-2; P26196: DDX6; NbExp=3; IntAct=EBI-11741437, EBI-351257;
CC       Q08117-2; Q9Y5R5: DMRT2; NbExp=3; IntAct=EBI-11741437, EBI-18072054;
CC       Q08117-2; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11741437, EBI-9679045;
CC       Q08117-2; Q96MA1: DMRTB1; NbExp=3; IntAct=EBI-11741437, EBI-954466;
CC       Q08117-2; Q6PKX4: DOK6; NbExp=3; IntAct=EBI-11741437, EBI-2880244;
CC       Q08117-2; O14641: DVL2; NbExp=3; IntAct=EBI-11741437, EBI-740850;
CC       Q08117-2; Q92997: DVL3; NbExp=3; IntAct=EBI-11741437, EBI-739789;
CC       Q08117-2; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-11741437, EBI-740680;
CC       Q08117-2; O95967: EFEMP2; NbExp=6; IntAct=EBI-11741437, EBI-743414;
CC       Q08117-2; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-11741437, EBI-743105;
CC       Q08117-2; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-11741437, EBI-750700;
CC       Q08117-2; P50548: ERF; NbExp=3; IntAct=EBI-11741437, EBI-8465203;
CC       Q08117-2; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-11741437, EBI-371876;
CC       Q08117-2; O00167-2: EYA2; NbExp=3; IntAct=EBI-11741437, EBI-12807776;
CC       Q08117-2; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-11741437, EBI-11986315;
CC       Q08117-2; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-11741437, EBI-12193763;
CC       Q08117-2; Q9NTX9: FAM217B; NbExp=3; IntAct=EBI-11741437, EBI-19153639;
CC       Q08117-2; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-11741437, EBI-6658203;
CC       Q08117-2; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-11741437, EBI-11958845;
CC       Q08117-2; Q13643: FHL3; NbExp=4; IntAct=EBI-11741437, EBI-741101;
CC       Q08117-2; P53539: FOSB; NbExp=3; IntAct=EBI-11741437, EBI-2806743;
CC       Q08117-2; O60548: FOXD2; NbExp=3; IntAct=EBI-11741437, EBI-17282008;
CC       Q08117-2; O15353: FOXN1; NbExp=3; IntAct=EBI-11741437, EBI-11319000;
CC       Q08117-2; O15409: FOXP2; NbExp=3; IntAct=EBI-11741437, EBI-983612;
CC       Q08117-2; O43559: FRS3; NbExp=5; IntAct=EBI-11741437, EBI-725515;
CC       Q08117-2; A1L4K1: FSD2; NbExp=3; IntAct=EBI-11741437, EBI-5661036;
CC       Q08117-2; P15976-2: GATA1; NbExp=5; IntAct=EBI-11741437, EBI-9090198;
CC       Q08117-2; Q96CN9: GCC1; NbExp=3; IntAct=EBI-11741437, EBI-746252;
CC       Q08117-2; P55040: GEM; NbExp=3; IntAct=EBI-11741437, EBI-744104;
CC       Q08117-2; O75420: GIGYF1; NbExp=3; IntAct=EBI-11741437, EBI-947774;
CC       Q08117-2; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-11741437, EBI-7251368;
CC       Q08117-2; Q08379: GOLGA2; NbExp=6; IntAct=EBI-11741437, EBI-618309;
CC       Q08117-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11741437, EBI-5916454;
CC       Q08117-2; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-11741437, EBI-739467;
CC       Q08117-2; O95872: GPANK1; NbExp=3; IntAct=EBI-11741437, EBI-751540;
CC       Q08117-2; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-11741437, EBI-11959863;
CC       Q08117-2; P28799: GRN; NbExp=3; IntAct=EBI-11741437, EBI-747754;
CC       Q08117-2; P13807: GYS1; NbExp=5; IntAct=EBI-11741437, EBI-740553;
CC       Q08117-2; P56524-2: HDAC4; NbExp=3; IntAct=EBI-11741437, EBI-11953488;
CC       Q08117-2; Q9BSH5: HDHD3; NbExp=3; IntAct=EBI-11741437, EBI-745201;
CC       Q08117-2; A0A087WSW0: HELT; NbExp=4; IntAct=EBI-11741437, EBI-12057631;
CC       Q08117-2; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-11741437, EBI-5460660;
CC       Q08117-2; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-11741437, EBI-16429135;
CC       Q08117-2; O14964: HGS; NbExp=8; IntAct=EBI-11741437, EBI-740220;
CC       Q08117-2; Q03014: HHEX; NbExp=3; IntAct=EBI-11741437, EBI-747421;
CC       Q08117-2; P52597: HNRNPF; NbExp=3; IntAct=EBI-11741437, EBI-352986;
CC       Q08117-2; P61978-2: HNRNPK; NbExp=5; IntAct=EBI-11741437, EBI-7060731;
CC       Q08117-2; P49639: HOXA1; NbExp=3; IntAct=EBI-11741437, EBI-740785;
CC       Q08117-2; P09067: HOXB5; NbExp=5; IntAct=EBI-11741437, EBI-3893317;
CC       Q08117-2; P31273: HOXC8; NbExp=3; IntAct=EBI-11741437, EBI-1752118;
CC       Q08117-2; P31274: HOXC9; NbExp=3; IntAct=EBI-11741437, EBI-1779423;
CC       Q08117-2; Q9UKT9: IKZF3; NbExp=5; IntAct=EBI-11741437, EBI-747204;
CC       Q08117-2; Q9C086: INO80B; NbExp=5; IntAct=EBI-11741437, EBI-715611;
CC       Q08117-2; Q8NBZ0: INO80E; NbExp=3; IntAct=EBI-11741437, EBI-769401;
CC       Q08117-2; Q15735: INPP5J; NbExp=3; IntAct=EBI-11741437, EBI-10236940;
CC       Q08117-2; Q9BZI1: IRX2; NbExp=3; IntAct=EBI-11741437, EBI-12166369;
CC       Q08117-2; P78412: IRX6; NbExp=5; IntAct=EBI-11741437, EBI-12100506;
CC       Q08117-2; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-11741437, EBI-2556193;
CC       Q08117-2; O60341: KDM1A; NbExp=3; IntAct=EBI-11741437, EBI-710124;
CC       Q08117-2; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-11741437, EBI-14069005;
CC       Q08117-2; Q13351: KLF1; NbExp=3; IntAct=EBI-11741437, EBI-8284732;
CC       Q08117-2; O43474: KLF4; NbExp=3; IntAct=EBI-11741437, EBI-7232405;
CC       Q08117-2; Q96G42: KLHDC7B; NbExp=3; IntAct=EBI-11741437, EBI-9478422;
CC       Q08117-2; O76011: KRT34; NbExp=3; IntAct=EBI-11741437, EBI-1047093;
CC       Q08117-2; Q92764: KRT35; NbExp=3; IntAct=EBI-11741437, EBI-1058674;
CC       Q08117-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-11741437, EBI-10171697;
CC       Q08117-2; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-11741437, EBI-10217483;
CC       Q08117-2; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11741437, EBI-10172290;
CC       Q08117-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11741437, EBI-10171774;
CC       Q08117-2; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11741437, EBI-1052037;
CC       Q08117-2; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11741437, EBI-10176379;
CC       Q08117-2; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-11741437, EBI-11953846;
CC       Q08117-2; Q3SY46: KRTAP13-3; NbExp=5; IntAct=EBI-11741437, EBI-10241252;
CC       Q08117-2; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11741437, EBI-11988175;
CC       Q08117-2; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-11741437, EBI-1048945;
CC       Q08117-2; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-11741437, EBI-10241353;
CC       Q08117-2; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-11741437, EBI-11962084;
CC       Q08117-2; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-11741437, EBI-18394498;
CC       Q08117-2; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-11741437, EBI-10261141;
CC       Q08117-2; P01130: LDLR; NbExp=3; IntAct=EBI-11741437, EBI-988319;
CC       Q08117-2; O95751: LDOC1; NbExp=3; IntAct=EBI-11741437, EBI-740738;
CC       Q08117-2; Q96PV6: LENG8; NbExp=3; IntAct=EBI-11741437, EBI-739546;
CC       Q08117-2; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-11741437, EBI-12039345;
CC       Q08117-2; P25791-3: LMO2; NbExp=3; IntAct=EBI-11741437, EBI-11959475;
CC       Q08117-2; P61968: LMO4; NbExp=3; IntAct=EBI-11741437, EBI-2798728;
CC       Q08117-2; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-11741437, EBI-741037;
CC       Q08117-2; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-11741437, EBI-746778;
CC       Q08117-2; P28482: MAPK1; NbExp=3; IntAct=EBI-11741437, EBI-959949;
CC       Q08117-2; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-11741437, EBI-726739;
CC       Q08117-2; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-11741437, EBI-348259;
CC       Q08117-2; Q99750: MDFI; NbExp=3; IntAct=EBI-11741437, EBI-724076;
CC       Q08117-2; Q86YW9: MED12L; NbExp=3; IntAct=EBI-11741437, EBI-3957138;
CC       Q08117-2; Q71SY5: MED25; NbExp=3; IntAct=EBI-11741437, EBI-394558;
CC       Q08117-2; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-11741437, EBI-18582591;
CC       Q08117-2; P55081: MFAP1; NbExp=5; IntAct=EBI-11741437, EBI-1048159;
CC       Q08117-2; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-11741437, EBI-2801965;
CC       Q08117-2; Q13064: MKRN3; NbExp=5; IntAct=EBI-11741437, EBI-2340269;
CC       Q08117-2; P40692: MLH1; NbExp=3; IntAct=EBI-11741437, EBI-744248;
CC       Q08117-2; P55198: MLLT6; NbExp=3; IntAct=EBI-11741437, EBI-740216;
CC       Q08117-2; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-11741437, EBI-8852072;
CC       Q08117-2; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-11741437, EBI-10288852;
CC       Q08117-2; Q4VC12: MSS51; NbExp=3; IntAct=EBI-11741437, EBI-11599933;
CC       Q08117-2; P35548: MSX2; NbExp=3; IntAct=EBI-11741437, EBI-6447480;
CC       Q08117-2; Q5JR59-3: MTUS2; NbExp=6; IntAct=EBI-11741437, EBI-11522433;
CC       Q08117-2; P13349: MYF5; NbExp=3; IntAct=EBI-11741437, EBI-17491620;
CC       Q08117-2; A7E2Y1-2: MYH7B; NbExp=3; IntAct=EBI-11741437, EBI-12813813;
CC       Q08117-2; P15173: MYOG; NbExp=3; IntAct=EBI-11741437, EBI-3906629;
CC       Q08117-2; Q15742: NAB2; NbExp=3; IntAct=EBI-11741437, EBI-8641936;
CC       Q08117-2; Q96HR8: NAF1; NbExp=5; IntAct=EBI-11741437, EBI-2515597;
CC       Q08117-2; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-11741437, EBI-10249760;
CC       Q08117-2; P17568: NDUFB7; NbExp=3; IntAct=EBI-11741437, EBI-1246238;
CC       Q08117-2; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-11741437, EBI-11750983;
CC       Q08117-2; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11741437, EBI-22310682;
CC       Q08117-2; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-11741437, EBI-741158;
CC       Q08117-2; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-11741437, EBI-10297093;
CC       Q08117-2; P61970: NUTF2; NbExp=3; IntAct=EBI-11741437, EBI-591778;
CC       Q08117-2; Q7RTU3: OLIG3; NbExp=5; IntAct=EBI-11741437, EBI-10225049;
CC       Q08117-2; Q9UJX0: OSGIN1; NbExp=3; IntAct=EBI-11741437, EBI-9057006;
CC       Q08117-2; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-11741437, EBI-12813389;
CC       Q08117-2; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-11741437, EBI-10181968;
CC       Q08117-2; Q9HBI0: PARVG; NbExp=5; IntAct=EBI-11741437, EBI-3921217;
CC       Q08117-2; Q9HBE1-4: PATZ1; NbExp=5; IntAct=EBI-11741437, EBI-11022007;
CC       Q08117-2; Q06710: PAX8; NbExp=3; IntAct=EBI-11741437, EBI-2683132;
CC       Q08117-2; P55771: PAX9; NbExp=3; IntAct=EBI-11741437, EBI-12111000;
CC       Q08117-2; Q15365: PCBP1; NbExp=3; IntAct=EBI-11741437, EBI-946095;
CC       Q08117-2; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11741437, EBI-11956269;
CC       Q08117-2; Q99471: PFDN5; NbExp=3; IntAct=EBI-11741437, EBI-357275;
CC       Q08117-2; O43189: PHF1; NbExp=3; IntAct=EBI-11741437, EBI-530034;
CC       Q08117-2; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-11741437, EBI-79165;
CC       Q08117-2; P78337: PITX1; NbExp=8; IntAct=EBI-11741437, EBI-748265;
CC       Q08117-2; Q99697-2: PITX2; NbExp=3; IntAct=EBI-11741437, EBI-12138495;
CC       Q08117-2; Q9UM63: PLAGL1; NbExp=3; IntAct=EBI-11741437, EBI-7233410;
CC       Q08117-2; O15160: POLR1C; NbExp=3; IntAct=EBI-11741437, EBI-1055079;
CC       Q08117-2; Q9GZV8: PRDM14; NbExp=5; IntAct=EBI-11741437, EBI-3957793;
CC       Q08117-2; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-11741437, EBI-11320284;
CC       Q08117-2; P54646: PRKAA2; NbExp=3; IntAct=EBI-11741437, EBI-1383852;
CC       Q08117-2; O43741: PRKAB2; NbExp=5; IntAct=EBI-11741437, EBI-1053424;
CC       Q08117-2; O75360: PROP1; NbExp=3; IntAct=EBI-11741437, EBI-9027467;
CC       Q08117-2; Q8WWY3: PRPF31; NbExp=10; IntAct=EBI-11741437, EBI-1567797;
CC       Q08117-2; P79522: PRR3; NbExp=3; IntAct=EBI-11741437, EBI-2803328;
CC       Q08117-2; P0CG20: PRR35; NbExp=5; IntAct=EBI-11741437, EBI-11986293;
CC       Q08117-2; P20618: PSMB1; NbExp=3; IntAct=EBI-11741437, EBI-372273;
CC       Q08117-2; P28070: PSMB4; NbExp=5; IntAct=EBI-11741437, EBI-603350;
CC       Q08117-2; O75771: RAD51D; NbExp=3; IntAct=EBI-11741437, EBI-1055693;
CC       Q08117-2; Q93062-3: RBPMS; NbExp=5; IntAct=EBI-11741437, EBI-740343;
CC       Q08117-2; Q8N443: RIBC1; NbExp=3; IntAct=EBI-11741437, EBI-10265323;
CC       Q08117-2; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-11741437, EBI-10226430;
CC       Q08117-2; Q92753-1: RORB; NbExp=3; IntAct=EBI-11741437, EBI-18560266;
CC       Q08117-2; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-11741437, EBI-6257312;
CC       Q08117-2; P21673: SAT1; NbExp=3; IntAct=EBI-11741437, EBI-711613;
CC       Q08117-2; Q9BWG6: SCNM1; NbExp=5; IntAct=EBI-11741437, EBI-748391;
CC       Q08117-2; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-11741437, EBI-748621;
CC       Q08117-2; Q01105-2: SET; NbExp=3; IntAct=EBI-11741437, EBI-7481343;
CC       Q08117-2; Q15427: SF3B4; NbExp=3; IntAct=EBI-11741437, EBI-348469;
CC       Q08117-2; O14492-2: SH2B2; NbExp=3; IntAct=EBI-11741437, EBI-19952306;
CC       Q08117-2; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11741437, EBI-11955083;
CC       Q08117-2; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-11741437, EBI-12037847;
CC       Q08117-2; Q15475: SIX1; NbExp=6; IntAct=EBI-11741437, EBI-743675;
CC       Q08117-2; Q9NPC8: SIX2; NbExp=3; IntAct=EBI-11741437, EBI-12695166;
CC       Q08117-2; P84022: SMAD3; NbExp=3; IntAct=EBI-11741437, EBI-347161;
CC       Q08117-2; Q13485: SMAD4; NbExp=3; IntAct=EBI-11741437, EBI-347263;
CC       Q08117-2; Q12824-2: SMARCB1; NbExp=3; IntAct=EBI-11741437, EBI-358436;
CC       Q08117-2; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-11741437, EBI-358489;
CC       Q08117-2; P09012: SNRPA; NbExp=3; IntAct=EBI-11741437, EBI-607085;
CC       Q08117-2; P09234: SNRPC; NbExp=3; IntAct=EBI-11741437, EBI-766589;
CC       Q08117-2; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-11741437, EBI-12288855;
CC       Q08117-2; P35711-4: SOX5; NbExp=3; IntAct=EBI-11741437, EBI-11954419;
CC       Q08117-2; Q9BR10: SPATA25; NbExp=3; IntAct=EBI-11741437, EBI-12926726;
CC       Q08117-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-11741437, EBI-742688;
CC       Q08117-2; Q96LM6: SPMIP9; NbExp=3; IntAct=EBI-11741437, EBI-743976;
CC       Q08117-2; O75558: STX11; NbExp=3; IntAct=EBI-11741437, EBI-714135;
CC       Q08117-2; Q9UMX1: SUFU; NbExp=3; IntAct=EBI-11741437, EBI-740595;
CC       Q08117-2; O95947: TBX6; NbExp=3; IntAct=EBI-11741437, EBI-2824328;
CC       Q08117-2; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11741437, EBI-11955057;
CC       Q08117-2; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-11741437, EBI-11746252;
CC       Q08117-2; Q15561: TEAD4; NbExp=3; IntAct=EBI-11741437, EBI-747736;
CC       Q08117-2; Q96A09: TENT5B; NbExp=6; IntAct=EBI-11741437, EBI-752030;
CC       Q08117-2; Q7Z6R9: TFAP2D; NbExp=5; IntAct=EBI-11741437, EBI-11952651;
CC       Q08117-2; Q9BT49: THAP7; NbExp=3; IntAct=EBI-11741437, EBI-741350;
CC       Q08117-2; Q6B0B8: TIGD3; NbExp=3; IntAct=EBI-11741437, EBI-12140557;
CC       Q08117-2; Q08117-2: TLE5; NbExp=5; IntAct=EBI-11741437, EBI-11741437;
CC       Q08117-2; Q13077: TRAF1; NbExp=6; IntAct=EBI-11741437, EBI-359224;
CC       Q08117-2; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-11741437, EBI-492476;
CC       Q08117-2; Q12899: TRIM26; NbExp=3; IntAct=EBI-11741437, EBI-2341136;
CC       Q08117-2; Q8WV44: TRIM41; NbExp=5; IntAct=EBI-11741437, EBI-725997;
CC       Q08117-2; Q15654: TRIP6; NbExp=3; IntAct=EBI-11741437, EBI-742327;
CC       Q08117-2; Q8IZ69: TRMT2A; NbExp=3; IntAct=EBI-11741437, EBI-2515774;
CC       Q08117-2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-11741437, EBI-12806590;
CC       Q08117-2; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-11741437, EBI-372432;
CC       Q08117-2; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11741437, EBI-10241197;
CC       Q08117-2; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-11741437, EBI-9090990;
CC       Q08117-2; P26368-2: U2AF2; NbExp=3; IntAct=EBI-11741437, EBI-11097439;
CC       Q08117-2; Q5T6F2: UBAP2; NbExp=3; IntAct=EBI-11741437, EBI-2514383;
CC       Q08117-2; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-11741437, EBI-607755;
CC       Q08117-2; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-11741437, EBI-11524408;
CC       Q08117-2; O75604: USP2; NbExp=5; IntAct=EBI-11741437, EBI-743272;
CC       Q08117-2; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-11741437, EBI-11975223;
CC       Q08117-2; Q14119: VEZF1; NbExp=3; IntAct=EBI-11741437, EBI-11980193;
CC       Q08117-2; Q99990: VGLL1; NbExp=3; IntAct=EBI-11741437, EBI-11983165;
CC       Q08117-2; P08670: VIM; NbExp=3; IntAct=EBI-11741437, EBI-353844;
CC       Q08117-2; Q9H9H4: VPS37B; NbExp=3; IntAct=EBI-11741437, EBI-4400866;
CC       Q08117-2; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-11741437, EBI-2559305;
CC       Q08117-2; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-11741437, EBI-1051237;
CC       Q08117-2; Q05516: ZBTB16; NbExp=3; IntAct=EBI-11741437, EBI-711925;
CC       Q08117-2; O43167: ZBTB24; NbExp=3; IntAct=EBI-11741437, EBI-744471;
CC       Q08117-2; Q9UFB7: ZBTB47; NbExp=5; IntAct=EBI-11741437, EBI-7781767;
CC       Q08117-2; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-11741437, EBI-10237226;
CC       Q08117-2; A0A0S2Z6H0: ZGPAT; NbExp=3; IntAct=EBI-11741437, EBI-16428984;
CC       Q08117-2; Q8N5A5-2: ZGPAT; NbExp=9; IntAct=EBI-11741437, EBI-10183064;
CC       Q08117-2; Q15915: ZIC1; NbExp=3; IntAct=EBI-11741437, EBI-11963196;
CC       Q08117-2; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-11741437, EBI-12030590;
CC       Q08117-2; Q9Y3S2: ZNF330; NbExp=5; IntAct=EBI-11741437, EBI-373456;
CC       Q08117-2; Q8NA42: ZNF383; NbExp=3; IntAct=EBI-11741437, EBI-20110775;
CC       Q08117-2; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-11741437, EBI-347633;
CC       Q08117-2; Q96IQ9: ZNF414; NbExp=5; IntAct=EBI-11741437, EBI-744257;
CC       Q08117-2; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11741437, EBI-740727;
CC       Q08117-2; Q7Z7K2: ZNF467; NbExp=3; IntAct=EBI-11741437, EBI-11986485;
CC       Q08117-2; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-11741437, EBI-12006434;
CC       Q08117-2; Q96F45: ZNF503; NbExp=3; IntAct=EBI-11741437, EBI-8832437;
CC       Q08117-2; Q96C55: ZNF524; NbExp=3; IntAct=EBI-11741437, EBI-10283126;
CC       Q08117-2; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-11741437, EBI-4395732;
CC       Q08117-2; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11741437, EBI-10240849;
CC       Q08117-2; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-11741437, EBI-5667516;
CC       Q08117-2; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-11741437, EBI-527853;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=AES-1;
CC         IsoId=Q08117-1; Sequence=Displayed;
CC       Name=2; Synonyms=AES-2;
CC         IsoId=Q08117-2; Sequence=VSP_043527;
CC   -!- TISSUE SPECIFICITY: Found predominantly in muscle, heart and Placenta.
CC       In fetal tissues, abundantly expressed in the heart, lung, kidney,
CC       brain and liver.
CC   -!- DOMAIN: Lacks the C-terminal WD repeats.
CC   -!- PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC35517.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U04241; AAA16223.1; -; mRNA.
DR   EMBL; U88832; AAD00654.1; -; Genomic_DNA.
DR   EMBL; U88831; AAD00654.1; JOINED; Genomic_DNA.
DR   EMBL; AF072902; AAC35517.1; ALT_INIT; mRNA.
DR   EMBL; AK094591; BAG52894.1; -; mRNA.
DR   EMBL; AK314713; BAG37257.1; -; mRNA.
DR   EMBL; AC005944; AAC72103.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW69345.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW69347.1; -; Genomic_DNA.
DR   EMBL; BC113735; AAI13736.1; -; mRNA.
DR   EMBL; BC113737; AAI13738.1; -; mRNA.
DR   EMBL; X73358; CAA51768.1; -; mRNA.
DR   CCDS; CCDS12101.1; -. [Q08117-2]
DR   CCDS; CCDS12102.1; -. [Q08117-1]
DR   PIR; G01236; G01236.
DR   PIR; S35678; S35678.
DR   PIR; S35679; S35679.
DR   RefSeq; NP_001121.2; NM_001130.5. [Q08117-1]
DR   RefSeq; NP_945320.1; NM_198969.1. [Q08117-2]
DR   RefSeq; NP_945321.1; NM_198970.1.
DR   AlphaFoldDB; Q08117; -.
DR   SMR; Q08117; -.
DR   BioGRID; 106675; 437.
DR   IntAct; Q08117; 430.
DR   MINT; Q08117; -.
DR   STRING; 9606.ENSP00000221561; -.
DR   MoonDB; Q08117; Predicted.
DR   GlyCosmos; Q08117; 7 sites, 2 glycans.
DR   GlyGen; Q08117; 7 sites, 2 O-linked glycans (7 sites).
DR   iPTMnet; Q08117; -.
DR   PhosphoSitePlus; Q08117; -.
DR   BioMuta; AES; -.
DR   DMDM; 23503062; -.
DR   EPD; Q08117; -.
DR   jPOST; Q08117; -.
DR   MassIVE; Q08117; -.
DR   MaxQB; Q08117; -.
DR   PaxDb; 9606-ENSP00000221561; -.
DR   PeptideAtlas; Q08117; -.
DR   ProteomicsDB; 58572; -. [Q08117-1]
DR   ProteomicsDB; 58573; -. [Q08117-2]
DR   Pumba; Q08117; -.
DR   Antibodypedia; 10920; 428 antibodies from 36 providers.
DR   DNASU; 166; -.
DR   Ensembl; ENST00000221561.12; ENSP00000221561.7; ENSG00000104964.15. [Q08117-2]
DR   Ensembl; ENST00000327141.9; ENSP00000317537.4; ENSG00000104964.15. [Q08117-1]
DR   GeneID; 166; -.
DR   KEGG; hsa:166; -.
DR   MANE-Select; ENST00000327141.9; ENSP00000317537.4; NM_001130.6; NP_001121.2.
DR   UCSC; uc002lwy.2; human. [Q08117-1]
DR   AGR; HGNC:307; -.
DR   CTD; 166; -.
DR   DisGeNET; 166; -.
DR   GeneCards; TLE5; -.
DR   HGNC; HGNC:307; TLE5.
DR   HPA; ENSG00000104964; Low tissue specificity.
DR   MIM; 600188; gene.
DR   neXtProt; NX_Q08117; -.
DR   OpenTargets; ENSG00000104964; -.
DR   PharmGKB; PA24606; -.
DR   VEuPathDB; HostDB:ENSG00000104964; -.
DR   eggNOG; KOG0639; Eukaryota.
DR   GeneTree; ENSGT01030000234519; -.
DR   HOGENOM; CLU_092092_0_0_1; -.
DR   InParanoid; Q08117; -.
DR   OMA; GDTHQDD; -.
DR   OrthoDB; 3147966at2759; -.
DR   PhylomeDB; Q08117; -.
DR   PathwayCommons; Q08117; -.
DR   Reactome; R-HSA-4641265; Repression of WNT target genes.
DR   SignaLink; Q08117; -.
DR   SIGNOR; Q08117; -.
DR   BioGRID-ORCS; 166; 10 hits in 1166 CRISPR screens.
DR   ChiTaRS; AES; human.
DR   GenomeRNAi; 166; -.
DR   Pharos; Q08117; Tbio.
DR   PRO; PR:Q08117; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q08117; Protein.
DR   Bgee; ENSG00000104964; Expressed in right hemisphere of cerebellum and 199 other cell types or tissues.
DR   ExpressionAtlas; Q08117; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
DR   GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:UniProtKB.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
DR   GO; GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
DR   GO; GO:0060761; P:negative regulation of response to cytokine stimulus; IMP:BHF-UCL.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:BHF-UCL.
DR   GO; GO:2000210; P:positive regulation of anoikis; IMP:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEA:Ensembl.
DR   GO; GO:0070555; P:response to interleukin-1; IDA:BHF-UCL.
DR   GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR   PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR   Pfam; PF03920; TLE_N; 1.
DR   Genevisible; Q08117; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Nucleus; Phosphoprotein; Reference proteome;
KW   Repressor; Transcription; Transcription regulation; Ubl conjugation;
KW   Wnt signaling pathway.
FT   CHAIN           1..197
FT                   /note="TLE family member 5"
FT                   /id="PRO_0000050834"
FT   REGION          166..197
FT                   /note="CCN domain"
FT   REGION          174..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..197
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         196
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:20068231"
FT   VAR_SEQ         1..9
FT                   /note="MMFPQSRHS -> MCHKNGFPQEGGITAAFLQKRKLRLSKNHRPARAKVTEH
FT                   VRGTRPGRATAGPAASTRAAGSLFFDRWGNRGPAGCR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:8365415"
FT                   /id="VSP_043527"
FT   VARIANT         168
FT                   /note="A -> E (in dbSNP:rs1802578)"
FT                   /id="VAR_011958"
FT   CONFLICT        30
FT                   /note="K -> T (in Ref. 2 and 5)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   197 AA;  21970 MW;  3851663AA6921A9F CRC64;
     MMFPQSRHSG SSHLPQQLKF TTSDSCDRIK DEFQLLQAQY HSLKLECDKL ASEKSEMQRH
     YVMYYEMSYG LNIEMHKQAE IVKRLNGICA QVLPYLSQEH QQQVLGAIER AKQVTAPELN
     SIIRQQLQAH QLSQLQALAL PLTPLPVGLQ PPSLPAVSAG TGLLSLSALG SQAHLSKEDK
     NGHDGDTHQE DDGEKSD
//