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Protein

Regulator of G-protein signaling 1

Gene

RGS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541).By similarity2 Publications

GO - Molecular functioni

  • calmodulin binding Source: ProtInc
  • G-protein alpha-subunit binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • immune response Source: ProtInc
  • leukotriene signaling pathway Source: UniProtKB
  • negative regulation of signal transduction Source: UniProtKB-KW
  • positive regulation of GTPase activity Source: UniProtKB
  • regulation of G-protein coupled receptor protein signaling pathway Source: InterPro
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Signal transduction inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090104-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 1
Short name:
RGS1
Alternative name(s):
B-cell activation protein BL341 Publication
Early response protein 1R20
Gene namesi
Name:RGS1
Synonyms:1R20, BL34, IER1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9991. RGS1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5996.
OpenTargetsiENSG00000090104.
PharmGKBiPA34361.

Polymorphism and mutation databases

BioMutaiRGS1.
DMDMi229470360.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041751 – 209Regulator of G-protein signaling 1Add BLAST209

Proteomic databases

PaxDbiQ08116.
PeptideAtlasiQ08116.
PRIDEiQ08116.

PTM databases

iPTMnetiQ08116.
PhosphoSitePlusiQ08116.

Expressioni

Tissue specificityi

Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).2 Publications

Inductioni

In response to several B-cell activation signals.1 Publication

Gene expression databases

BgeeiENSG00000090104.
CleanExiHS_RGS1.
ExpressionAtlasiQ08116. baseline and differential.
GenevisibleiQ08116. HS.

Organism-specific databases

HPAiCAB031489.

Interactioni

Subunit structurei

Interacts with GNAI1 and GNAQ.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: ProtInc
  • G-protein alpha-subunit binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111928. 7 interactors.
DIPiDIP-59091N.
IntActiQ08116. 5 interactors.
MINTiMINT-1367963.
STRINGi9606.ENSP00000356429.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi72 – 75Combined sources4
Helixi76 – 81Combined sources6
Turni82 – 84Combined sources3
Helixi86 – 91Combined sources6
Helixi93 – 105Combined sources13
Helixi110 – 122Combined sources13
Helixi126 – 128Combined sources3
Helixi129 – 140Combined sources12
Helixi153 – 163Combined sources11
Turni168 – 171Combined sources4
Helixi172 – 184Combined sources13
Helixi186 – 191Combined sources6
Helixi194 – 202Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BV1X-ray2.00A/B63-205[»]
2GTPX-ray2.55C/D63-205[»]
ProteinModelPortaliQ08116.
SMRiQ08116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ08116.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 200RGSPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ08116.
KOiK16449.
OMAiKIYKAFV.
OrthoDBiEOG091G0BDG.
PhylomeDBiQ08116.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR030409. RGS1.
IPR024066. RGS_subdom1.
[Graphical view]
PANTHERiPTHR10845:SF34. PTHR10845:SF34. 1 hit.
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q08116-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRAAAISTPK LDKMPGMFFS ANPKELKGTT HSLLDDKMQK RRPKTFGMDM
60 70 80 90 100
KAYLRSMIPH LESGMKSSKS KDVLSAAEVM QWSQSLEKLL ANQTGQNVFG
110 120 130 140 150
SFLKSEFSEE NIEFWLACED YKKTESDLLP CKAEEIYKAF VHSDAAKQIN
160 170 180 190 200
IDFRTRESTA KKIKAPTPTC FDEAQKVIYT LMEKDSYPRF LKSDIYLNLL

NDLQANSLK
Length:209
Mass (Da):23,858
Last modified:March 24, 2009 - v3
Checksum:iD8D7D8E80819496A
GO
Isoform 2 (identifier: Q08116-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-209: INIDFRTRES...LNDLQANSLK → VSIKLIIISFSIKDPICRNNI

Show »
Length:169
Mass (Da):19,134
Checksum:i96E56F3B53747867
GO

Sequence cautioni

The sequence AAB26289 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH15510 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37976 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG64242 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA51826 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177V → A in BAG37976 (PubMed:14702039).Curated1
Sequence conflicti194D → H in CAA51826 (PubMed:8241276).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036422149 – 209INIDF…ANSLK → VSIKLIIISFSIKDPICRNN I in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303138 mRNA. Translation: BAG64242.1. Different initiation.
AK315607 mRNA. Translation: BAG37976.1. Different initiation.
AL136987 Genomic DNA. Translation: CAC19805.1.
BC015510 mRNA. Translation: AAH15510.1. Different initiation.
S59049 mRNA. Translation: AAB26289.1. Different initiation.
X73427 mRNA. Translation: CAA51826.1. Different initiation.
AF493925 mRNA. Translation: AAM12639.1.
BT006668 mRNA. Translation: AAP35314.1.
CCDSiCCDS1375.2. [Q08116-1]
PIRiS43436.
RefSeqiNP_002913.3. NM_002922.3. [Q08116-1]
UniGeneiHs.75256.

Genome annotation databases

EnsembliENST00000367459; ENSP00000356429; ENSG00000090104. [Q08116-1]
ENST00000469578; ENSP00000464323; ENSG00000090104. [Q08116-2]
GeneIDi5996.
KEGGihsa:5996.
UCSCiuc001gsi.2. human. [Q08116-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303138 mRNA. Translation: BAG64242.1. Different initiation.
AK315607 mRNA. Translation: BAG37976.1. Different initiation.
AL136987 Genomic DNA. Translation: CAC19805.1.
BC015510 mRNA. Translation: AAH15510.1. Different initiation.
S59049 mRNA. Translation: AAB26289.1. Different initiation.
X73427 mRNA. Translation: CAA51826.1. Different initiation.
AF493925 mRNA. Translation: AAM12639.1.
BT006668 mRNA. Translation: AAP35314.1.
CCDSiCCDS1375.2. [Q08116-1]
PIRiS43436.
RefSeqiNP_002913.3. NM_002922.3. [Q08116-1]
UniGeneiHs.75256.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BV1X-ray2.00A/B63-205[»]
2GTPX-ray2.55C/D63-205[»]
ProteinModelPortaliQ08116.
SMRiQ08116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111928. 7 interactors.
DIPiDIP-59091N.
IntActiQ08116. 5 interactors.
MINTiMINT-1367963.
STRINGi9606.ENSP00000356429.

PTM databases

iPTMnetiQ08116.
PhosphoSitePlusiQ08116.

Polymorphism and mutation databases

BioMutaiRGS1.
DMDMi229470360.

Proteomic databases

PaxDbiQ08116.
PeptideAtlasiQ08116.
PRIDEiQ08116.

Protocols and materials databases

DNASUi5996.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367459; ENSP00000356429; ENSG00000090104. [Q08116-1]
ENST00000469578; ENSP00000464323; ENSG00000090104. [Q08116-2]
GeneIDi5996.
KEGGihsa:5996.
UCSCiuc001gsi.2. human. [Q08116-1]

Organism-specific databases

CTDi5996.
DisGeNETi5996.
GeneCardsiRGS1.
H-InvDBHIX0001431.
HGNCiHGNC:9991. RGS1.
HPAiCAB031489.
MIMi600323. gene.
neXtProtiNX_Q08116.
OpenTargetsiENSG00000090104.
PharmGKBiPA34361.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ08116.
KOiK16449.
OMAiKIYKAFV.
OrthoDBiEOG091G0BDG.
PhylomeDBiQ08116.
TreeFamiTF315837.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090104-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiRGS1. human.
EvolutionaryTraceiQ08116.
GeneWikiiRGS1.
GenomeRNAii5996.
PROiQ08116.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090104.
CleanExiHS_RGS1.
ExpressionAtlasiQ08116. baseline and differential.
GenevisibleiQ08116. HS.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR030409. RGS1.
IPR024066. RGS_subdom1.
[Graphical view]
PANTHERiPTHR10845:SF34. PTHR10845:SF34. 1 hit.
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGS1_HUMAN
AccessioniPrimary (citable) accession number: Q08116
Secondary accession number(s): B2RDM9
, B4DZY0, Q07918, Q9H1W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: March 24, 2009
Last modified: November 2, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.