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Q08108

- PLB3_YEAST

UniProt

Q08108 - PLB3_YEAST

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Protein

Lysophospholipase 3

Gene

PLB3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Sequentially removes both fatty acyl groups from diacylglycerophospholipids and therefore has both phospholipase A and lysophospholipase activities. Substrate preference is phosphatidylserine > phosphatidylinositol. Does not cleave phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid and phosphatidylinositol-bisphosphate.1 Publication

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: SGD

GO - Biological processi

  1. phosphatidylinositol metabolic process Source: SGD
  2. phosphatidylserine catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YOL011W-MONOMER.
YEAST:YOL011W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 3 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 3
Gene namesi
Name:PLB3
Ordered Locus Names:YOL011W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOL011w.
SGDiS000005371. PLB3.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular region Source: SGD
  3. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 659633Lysophospholipase 3PRO_0000024648Add
BLAST
Propeptidei660 – 68627Removed in mature formSequence AnalysisPRO_0000372444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi547 – 5471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi571 – 5711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi588 – 5881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi614 – 6141N-linked (GlcNAc...)Sequence Analysis
Lipidationi659 – 6591GPI-anchor amidated asparagineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ08108.
PaxDbiQ08108.

Expressioni

Gene expression databases

GenevestigatoriQ08108.

Interactioni

Protein-protein interaction databases

BioGridi34393. 48 interactions.
DIPiDIP-4220N.
MINTiMINT-535513.
STRINGi4932.YOL011W.

Structurei

3D structure databases

ProteinModelPortaliQ08108.
SMRiQ08108. Positions 88-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 592554PLA2cPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 64317Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG271081.
GeneTreeiENSGT00510000051940.
HOGENOMiHOG000189547.
InParanoidiQ08108.
KOiK13333.
OMAiVYLNNFT.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08108-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRPLCSKII ISYIFAISQF LLAANAWSPT DSYVPGTVSC PDDINLVREA
60 70 80 90 100
TSISQNESAW LEKRNKVTSV ALKDFLTRAT ANFSDSSEVL SKLFNDGNSE
110 120 130 140 150
NLPKIAVAVS GGGYRSMLTG AGVLAAMDNR TEGAYEHGLG GLLQSTTYLS
160 170 180 190 200
GASGGNWLVG TLALNNWTSV QDILNNMQND DSIWDLSDSI VTPGGINIFK
210 220 230 240 250
TAKRWDHISN AVESKQNADY NTSLADIWGR ALAYNFFPSL NRGGIGLTWS
260 270 280 290 300
SIRDFPVFQN AEMPFPISVA DGRYPGTKVI NLNATVFEFN PFEMGSWDPS
310 320 330 340 350
LNSFANVKYL GTNVSNGVPL ERGKCTAGFD NAGFIMGTSS TLFNQFLLRI
360 370 380 390 400
NSTHLPSFIT RLARHFLKDL SQDFNDIAVY SPNPFKDTKF LDSDYTTSIV
410 420 430 440 450
DSDSLFLVDG GEDDENVPVL PLIQKERDVD IIFAVDNSAD MRLAWPDGSS
460 470 480 490 500
LVHTYERQFV KQGQGMSFPY VPDTNTFVNL GLNKKPTFFG CDANNLTDLQ
510 520 530 540 550
YIPPLVVYLP NAEYSFNSNQ SAFKLSYSES QRRSMIQNGF EIATRNNFTD
560 570 580 590 600
DPEFMGCVGC AIIRRKQQAL NITLPPECET CFKNYCWNGT LDTTPLPDVE
610 620 630 640 650
KDVHHSFINV NSFNSSIGQE ESLYAGSSAS QSSSSSSSSS SSSEIPSATA
660 670 680
TLEKKAATNS GSHLSGISVK FSAMIMLTLL MFTGAV
Length:686
Mass (Da):75,077
Last modified:November 1, 1997 - v1
Checksum:i95A2DBF41BF3E20F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z74753 Genomic DNA. Translation: CAA99010.1.
BK006948 Genomic DNA. Translation: DAA10772.1.
PIRiS66693.
RefSeqiNP_014632.1. NM_001183265.1.

Genome annotation databases

EnsemblFungiiYOL011W; YOL011W; YOL011W.
GeneIDi854151.
KEGGisce:YOL011W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z74753 Genomic DNA. Translation: CAA99010.1 .
BK006948 Genomic DNA. Translation: DAA10772.1 .
PIRi S66693.
RefSeqi NP_014632.1. NM_001183265.1.

3D structure databases

ProteinModelPortali Q08108.
SMRi Q08108. Positions 88-439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34393. 48 interactions.
DIPi DIP-4220N.
MINTi MINT-535513.
STRINGi 4932.YOL011W.

Proteomic databases

MaxQBi Q08108.
PaxDbi Q08108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOL011W ; YOL011W ; YOL011W .
GeneIDi 854151.
KEGGi sce:YOL011W.

Organism-specific databases

CYGDi YOL011w.
SGDi S000005371. PLB3.

Phylogenomic databases

eggNOGi NOG271081.
GeneTreei ENSGT00510000051940.
HOGENOMi HOG000189547.
InParanoidi Q08108.
KOi K13333.
OMAi VYLNNFT.
OrthoDBi EOG7N37NC.

Enzyme and pathway databases

BioCyci MetaCyc:YOL011W-MONOMER.
YEAST:YOL011W-MONOMER.

Miscellaneous databases

NextBioi 975905.

Gene expression databases

Genevestigatori Q08108.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae."
    Merkel O., Fido M., Mayr J.A., Prueger H., Raab F., Zandonella G., Kohlwein S.D., Paltauf F.
    J. Biol. Chem. 274:28121-28127(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPLB3_YEAST
AccessioniPrimary (citable) accession number: Q08108
Secondary accession number(s): D6W256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3