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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi393 – 400ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Sfri_2388
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000684 Componenti: Chromosome

Subcellular locationi

Q080T2:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei182 – 202HelicalUniRule annotationAdd BLAST21
Transmembranei267 – 287HelicalUniRule annotationAdd BLAST21
Transmembranei295 – 315HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716531 – 600Lipid A export ATP-binding/permease protein MsbAAdd BLAST600

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi318167.Sfri_2388.

Structurei

3D structure databases

ProteinModelPortaliQ080T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 327ABC transmembrane type-1UniRule annotationAdd BLAST301
Domaini359 – 596ABC transporterUniRule annotationAdd BLAST238

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q080T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASPKNEMW VVFKRLMAYV VPMKAMFIMA VLGLITYGAV DAAFIAFIKP
60 70 80 90 100
FIDEGFSQTP AIVAGVDLPT HGGFNANKDI MLMAPIAVIL MFSLRGVANF
110 120 130 140 150
VSTYCVSYMS AQLIMDMRQQ VFEHYLRLPV SYIDRENSGN LISRVTFDTE
160 170 180 190 200
QIARASGSAL ISIVRDSMTA IGMLGIMFYY SWKLSLCILV IGPIMGVVIS
210 220 230 240 250
VVSKRFRKVS KQIQSAMGGV TATTEQMIKG HKNVLVFGGQ KTEVERFFQV
260 270 280 290 300
NDRNRYQNMK LAVAQSISQP LIMVIGSFAL AFVLYAATWD SMKTDLTAGT
310 320 330 340 350
FAAILGAMLA MLQPIKNLTR VNAEFQRGIA ACTTVFELLD TAPEPDNGVF
360 370 380 390 400
SIDRVEGKLA FDNVTFAYPG QEKSALNGIN FEVKPGKTVA LVGRSGSGKS
410 420 430 440 450
TIASLITRFY GDLSTGDIRL DDTSIYDYQL KSLRNQVALV SQQVTLFNDT
460 470 480 490 500
IANNIAYAYP GEVTREQIVH AAELAYAMEF IDTLPEGLDT QVGENGVLLS
510 520 530 540 550
GGQRQRIAIA RAMLRDAPVL ILDEATSALD TESEKAIQKG LDNLRHNRTS
560 570 580 590 600
IVIAHRLSTI ESADEILVID QGKIVERGNH SELIAQAGIY ANLYQMQFSQ
Length:600
Mass (Da):65,855
Last modified:October 31, 2006 - v1
Checksum:iBBEA260F15C7B706
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI72233.1.
RefSeqiWP_011637842.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI72233; ABI72233; Sfri_2388.
KEGGisfr:Sfri_2388.

Similar proteinsi

Entry informationi

Entry nameiMSBA_SHEFN
AccessioniPrimary (citable) accession number: Q080T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 31, 2006
Last modified: October 25, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families