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Protein

Acetate kinase

Gene

ackA

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg(2+). Can also accept Mn2+.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101MagnesiumUniRule annotation
Binding sitei17 – 171ATPUniRule annotation
Binding sitei91 – 911SubstrateUniRule annotation
Active sitei148 – 1481Proton donor/acceptorUniRule annotation
Sitei180 – 1801Transition state stabilizerUniRule annotation
Sitei241 – 2411Transition state stabilizerUniRule annotation
Metal bindingi385 – 3851MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi208 – 2125ATPUniRule annotation
Nucleotide bindingi283 – 2853ATPUniRule annotation
Nucleotide bindingi331 – 3355ATPUniRule annotation

GO - Molecular functioni

  1. acetate kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. organic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFRI318167:GIXS-2559-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Sfri_2476
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000684 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Acetate kinasePRO_1000002254Add
BLAST

Proteomic databases

PRIDEiQ080J4.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi318167.Sfri_2476.

Structurei

3D structure databases

ProteinModelPortaliQ080J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288398.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q080J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKLVLVLN CGSSSLKFAI IDAQSGDDKV SGLAECFGLE DSRIKWKFDG
60 70 80 90 100
GKNEAKLGAF TAHREAVEFI VNNILAEHPE LAAQIKAVGH RIVHGGEKFT
110 120 130 140 150
RSVIVTPEVI QGIEDCASLA PLHNPAHLIG IRAALASFPA LPQVAVFDTA
160 170 180 190 200
FHQTMPEKAY IYALPYKLYR EHSIRRYGMH GTSNIYICRE AAKVLGKETK
210 220 230 240 250
DTNIICAHLG NGASVTAIKD GKSVDTSMGL TPLEGLVMGT RCGDLDPSII
260 270 280 290 300
FHLVKQLGYT LDEVNNLLNK QSGLLGISEL TNDCRGIEEG YQDGHKGATL
310 320 330 340 350
ALDIFCYRLA KYIASYTVPL GRLDAIIFTG GIGENSDLIR EKVLNLLAIF
360 370 380 390 400
NFKVDDNLNK AARFGQQGII TQVGSPIAMV IPTNEEWVIA EDAIKLITAK
Length:400
Mass (Da):43,437
Last modified:October 31, 2006 - v1
Checksum:iEE08E536A64B94E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI72321.1.
RefSeqiWP_011637930.1. NC_008345.1.
YP_751159.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI72321; ABI72321; Sfri_2476.
KEGGisfr:Sfri_2476.
PATRICi23499001. VBISheFri14343_2571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000447 Genomic DNA. Translation: ABI72321.1.
RefSeqiWP_011637930.1. NC_008345.1.
YP_751159.1. NC_008345.1.

3D structure databases

ProteinModelPortaliQ080J4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi318167.Sfri_2476.

Proteomic databases

PRIDEiQ080J4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABI72321; ABI72321; Sfri_2476.
KEGGisfr:Sfri_2476.
PATRICi23499001. VBISheFri14343_2571.

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288398.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG69975F.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.
BioCyciSFRI318167:GIXS-2559-MONOMER.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIMB 400.

Entry informationi

Entry nameiACKA_SHEFN
AccessioniPrimary (citable) accession number: Q080J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: April 29, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.