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Q080J4

- ACKA_SHEFN

UniProt

Q080J4 - ACKA_SHEFN

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Protein
Acetate kinase
Gene
ackA, Sfri_2476
Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction By similarity.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+. Can also accept Mn2+ By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101Magnesium By similarity
Binding sitei17 – 171ATP By similarity
Binding sitei91 – 911Substrate By similarity
Active sitei148 – 1481Proton donor/acceptor By similarity
Sitei180 – 1801Transition state stabilizer By similarity
Sitei241 – 2411Transition state stabilizer By similarity
Metal bindingi385 – 3851Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi208 – 2125ATP By similarity
Nucleotide bindingi283 – 2853ATP By similarity
Nucleotide bindingi331 – 3355ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acetate kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. organic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFRI318167:GIXS-2559-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinase (EC:2.7.2.1)
Alternative name(s):
Acetokinase
Gene namesi
Name:ackA
Ordered Locus Names:Sfri_2476
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000684: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Acetate kinaseUniRule annotation
PRO_1000002254Add
BLAST

Proteomic databases

PRIDEiQ080J4.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi318167.Sfri_2476.

Structurei

3D structure databases

ProteinModelPortaliQ080J4.

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288398.
KOiK00925.
OMAiKYVTQRA.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q080J4-1 [UniParc]FASTAAdd to Basket

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MSDKLVLVLN CGSSSLKFAI IDAQSGDDKV SGLAECFGLE DSRIKWKFDG    50
GKNEAKLGAF TAHREAVEFI VNNILAEHPE LAAQIKAVGH RIVHGGEKFT 100
RSVIVTPEVI QGIEDCASLA PLHNPAHLIG IRAALASFPA LPQVAVFDTA 150
FHQTMPEKAY IYALPYKLYR EHSIRRYGMH GTSNIYICRE AAKVLGKETK 200
DTNIICAHLG NGASVTAIKD GKSVDTSMGL TPLEGLVMGT RCGDLDPSII 250
FHLVKQLGYT LDEVNNLLNK QSGLLGISEL TNDCRGIEEG YQDGHKGATL 300
ALDIFCYRLA KYIASYTVPL GRLDAIIFTG GIGENSDLIR EKVLNLLAIF 350
NFKVDDNLNK AARFGQQGII TQVGSPIAMV IPTNEEWVIA EDAIKLITAK 400
Length:400
Mass (Da):43,437
Last modified:October 31, 2006 - v1
Checksum:iEE08E536A64B94E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000447 Genomic DNA. Translation: ABI72321.1.
RefSeqiYP_751159.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI72321; ABI72321; Sfri_2476.
GeneIDi4279387.
KEGGisfr:Sfri_2476.
PATRICi23499001. VBISheFri14343_2571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000447 Genomic DNA. Translation: ABI72321.1 .
RefSeqi YP_751159.1. NC_008345.1.

3D structure databases

ProteinModelPortali Q080J4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 318167.Sfri_2476.

Proteomic databases

PRIDEi Q080J4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI72321 ; ABI72321 ; Sfri_2476 .
GeneIDi 4279387.
KEGGi sfr:Sfri_2476.
PATRICi 23499001. VBISheFri14343_2571.

Phylogenomic databases

eggNOGi COG0282.
HOGENOMi HOG000288398.
KOi K00925.
OMAi KYVTQRA.
OrthoDBi EOG69975F.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00458 .
BioCyci SFRI318167:GIXS-2559-MONOMER.

Family and domain databases

HAMAPi MF_00020. Acetate_kinase.
InterProi IPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view ]
PANTHERi PTHR21060. PTHR21060. 1 hit.
Pfami PF00871. Acetate_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSi PR00471. ACETATEKNASE.
TIGRFAMsi TIGR00016. ackA. 1 hit.
PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIMB 400.

Entry informationi

Entry nameiACKA_SHEFN
AccessioniPrimary (citable) accession number: Q080J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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