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Q080J4

- ACKA_SHEFN

UniProt

Q080J4 - ACKA_SHEFN

Protein

Acetate kinase

Gene

ackA

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

    Catalytic activityi

    ATP + acetate = ADP + acetyl phosphate.UniRule annotation

    Cofactori

    Mg2+. Can also accept Mn2+.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi10 – 101MagnesiumUniRule annotation
    Binding sitei17 – 171ATPUniRule annotation
    Binding sitei91 – 911SubstrateUniRule annotation
    Active sitei148 – 1481Proton donor/acceptorUniRule annotation
    Sitei180 – 1801Transition state stabilizerUniRule annotation
    Sitei241 – 2411Transition state stabilizerUniRule annotation
    Metal bindingi385 – 3851MagnesiumUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi208 – 2125ATPUniRule annotation
    Nucleotide bindingi283 – 2853ATPUniRule annotation
    Nucleotide bindingi331 – 3355ATPUniRule annotation

    GO - Molecular functioni

    1. acetate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
    2. organic acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFRI318167:GIXS-2559-MONOMER.
    UniPathwayiUPA00340; UER00458.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
    Alternative name(s):
    AcetokinaseUniRule annotation
    Gene namesi
    Name:ackAUniRule annotation
    Ordered Locus Names:Sfri_2476
    OrganismiShewanella frigidimarina (strain NCIMB 400)
    Taxonomic identifieri318167 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000000684: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Acetate kinasePRO_1000002254Add
    BLAST

    Proteomic databases

    PRIDEiQ080J4.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi318167.Sfri_2476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ080J4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0282.
    HOGENOMiHOG000288398.
    KOiK00925.
    OMAiKYVTQRA.
    OrthoDBiEOG69975F.

    Family and domain databases

    HAMAPiMF_00020. Acetate_kinase.
    InterProiIPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view]
    PANTHERiPTHR21060. PTHR21060. 1 hit.
    PfamiPF00871. Acetate_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSiPR00471. ACETATEKNASE.
    TIGRFAMsiTIGR00016. ackA. 1 hit.
    PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
    PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q080J4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKLVLVLN CGSSSLKFAI IDAQSGDDKV SGLAECFGLE DSRIKWKFDG    50
    GKNEAKLGAF TAHREAVEFI VNNILAEHPE LAAQIKAVGH RIVHGGEKFT 100
    RSVIVTPEVI QGIEDCASLA PLHNPAHLIG IRAALASFPA LPQVAVFDTA 150
    FHQTMPEKAY IYALPYKLYR EHSIRRYGMH GTSNIYICRE AAKVLGKETK 200
    DTNIICAHLG NGASVTAIKD GKSVDTSMGL TPLEGLVMGT RCGDLDPSII 250
    FHLVKQLGYT LDEVNNLLNK QSGLLGISEL TNDCRGIEEG YQDGHKGATL 300
    ALDIFCYRLA KYIASYTVPL GRLDAIIFTG GIGENSDLIR EKVLNLLAIF 350
    NFKVDDNLNK AARFGQQGII TQVGSPIAMV IPTNEEWVIA EDAIKLITAK 400
    Length:400
    Mass (Da):43,437
    Last modified:October 31, 2006 - v1
    Checksum:iEE08E536A64B94E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI72321.1.
    RefSeqiYP_751159.1. NC_008345.1.

    Genome annotation databases

    EnsemblBacteriaiABI72321; ABI72321; Sfri_2476.
    GeneIDi4279387.
    KEGGisfr:Sfri_2476.
    PATRICi23499001. VBISheFri14343_2571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI72321.1 .
    RefSeqi YP_751159.1. NC_008345.1.

    3D structure databases

    ProteinModelPortali Q080J4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318167.Sfri_2476.

    Proteomic databases

    PRIDEi Q080J4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI72321 ; ABI72321 ; Sfri_2476 .
    GeneIDi 4279387.
    KEGGi sfr:Sfri_2476.
    PATRICi 23499001. VBISheFri14343_2571.

    Phylogenomic databases

    eggNOGi COG0282.
    HOGENOMi HOG000288398.
    KOi K00925.
    OMAi KYVTQRA.
    OrthoDBi EOG69975F.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00458 .
    BioCyci SFRI318167:GIXS-2559-MONOMER.

    Family and domain databases

    HAMAPi MF_00020. Acetate_kinase.
    InterProi IPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR21060. PTHR21060. 1 hit.
    Pfami PF00871. Acetate_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSi PR00471. ACETATEKNASE.
    TIGRFAMsi TIGR00016. ackA. 1 hit.
    PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
    PS01076. ACETATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCIMB 400.

    Entry informationi

    Entry nameiACKA_SHEFN
    AccessioniPrimary (citable) accession number: Q080J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3