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Protein

Calponin-2

Gene

Cnn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

GO - Biological processi

  • actomyosin structure organization Source: InterPro
  • cellular response to mechanical stimulus Source: MGI
  • hemopoiesis Source: MGI
  • negative regulation of cell migration Source: MGI
  • negative regulation of phagocytosis Source: MGI
  • positive regulation of gene expression Source: MGI
  • regulation of actin filament-based process Source: MGI
  • regulation of cell proliferation Source: MGI
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-2
Alternative name(s):
Calponin H2, smooth muscle
Neutral calponin
Gene namesi
Name:Cnn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:105093. Cnn2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 305304Calponin-2PRO_0000204774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei8 – 81N6-acetyllysineCombined sources
Modified residuei25 – 251N6-acetyllysineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ08093.
PaxDbiQ08093.
PeptideAtlasiQ08093.
PRIDEiQ08093.

PTM databases

iPTMnetiQ08093.
PhosphoSiteiQ08093.

Expressioni

Tissue specificityi

Smooth muscle, and tissues containing significant amounts of smooth muscle.

Gene expression databases

BgeeiENSMUSG00000004665.
CleanExiMM_CNN2.
ExpressionAtlasiQ08093. baseline and differential.
GenevisibleiQ08093. MM.

Interactioni

Protein-protein interaction databases

BioGridi198791. 2 interactions.
IntActiQ08093. 2 interactions.
MINTiMINT-4091098.
STRINGi10090.ENSMUSP00000004784.

Structurei

3D structure databases

ProteinModelPortaliQ08093.
SMRiQ08093. Positions 13-153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 131104CHPROSITE-ProRule annotationAdd
BLAST
Repeati166 – 19126Calponin-like 1Add
BLAST
Repeati206 – 23126Calponin-like 2Add
BLAST
Repeati245 – 26925Calponin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 3 calponin-like repeats.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ08093.
OMAiIPDYQDE.
OrthoDBiEOG091G0LY2.
PhylomeDBiQ08093.
TreeFamiTF313921.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR029974. CNN2.
IPR003096. SM22_calponin.
[Graphical view]
PANTHERiPTHR18959:SF47. PTHR18959:SF47. 1 hit.
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRSWIEG LTGLSIGPDF
60 70 80 90 100
QKGLKDGVIL CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM
110 120 130 140 150
NPVDLFEAND LFESGNMTQV QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ
160 170 180 190 200
ERNFDDATMK AGQCVIGLQM GTNKCASQSG MTAYGTRRHL YDPKNHILPP
210 220 230 240 250
MDHCTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC DNSSMSLQMG
260 270 280 290 300
YTQGANQSGQ VFGLGRQIYD PKYCPQGSAA DGAPAGDGQG EAPEYLAYCQ

EEAGY
Length:305
Mass (Da):33,156
Last modified:October 1, 1994 - v1
Checksum:i91DCDB47BEED53F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19543 mRNA. Translation: CAA79603.1.
BC009144 mRNA. Translation: AAH09144.1.
BC018482 mRNA. Translation: AAH18482.1.
CCDSiCCDS24003.1.
PIRiS36147. S31485.
RefSeqiNP_031751.1. NM_007725.2.
UniGeneiMm.157770.

Genome annotation databases

EnsembliENSMUST00000004784; ENSMUSP00000004784; ENSMUSG00000004665.
GeneIDi12798.
KEGGimmu:12798.
UCSCiuc007gaz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19543 mRNA. Translation: CAA79603.1.
BC009144 mRNA. Translation: AAH09144.1.
BC018482 mRNA. Translation: AAH18482.1.
CCDSiCCDS24003.1.
PIRiS36147. S31485.
RefSeqiNP_031751.1. NM_007725.2.
UniGeneiMm.157770.

3D structure databases

ProteinModelPortaliQ08093.
SMRiQ08093. Positions 13-153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198791. 2 interactions.
IntActiQ08093. 2 interactions.
MINTiMINT-4091098.
STRINGi10090.ENSMUSP00000004784.

PTM databases

iPTMnetiQ08093.
PhosphoSiteiQ08093.

Proteomic databases

EPDiQ08093.
PaxDbiQ08093.
PeptideAtlasiQ08093.
PRIDEiQ08093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000004784; ENSMUSP00000004784; ENSMUSG00000004665.
GeneIDi12798.
KEGGimmu:12798.
UCSCiuc007gaz.1. mouse.

Organism-specific databases

CTDi1265.
MGIiMGI:105093. Cnn2.

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ08093.
OMAiIPDYQDE.
OrthoDBiEOG091G0LY2.
PhylomeDBiQ08093.
TreeFamiTF313921.

Miscellaneous databases

ChiTaRSiCnn2. mouse.
PROiQ08093.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004665.
CleanExiMM_CNN2.
ExpressionAtlasiQ08093. baseline and differential.
GenevisibleiQ08093. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR029974. CNN2.
IPR003096. SM22_calponin.
[Graphical view]
PANTHERiPTHR18959:SF47. PTHR18959:SF47. 1 hit.
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNN2_MOUSE
AccessioniPrimary (citable) accession number: Q08093
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.