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Q08093 (CNN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Calponin-2
Alternative name(s):
Calponin H2, smooth muscle
Neutral calponin
Gene names
Name:Cnn2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Tissue specificity

Smooth muscle, and tissues containing significant amounts of smooth muscle.

Sequence similarities

Belongs to the calponin family.

Contains 3 calponin-like repeats.

Contains 1 CH (calponin-homology) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 305304Calponin-2
PRO_0000204774

Regions

Domain28 – 131104CH
Repeat166 – 19126Calponin-like 1
Repeat206 – 23126Calponin-like 2
Repeat245 – 26925Calponin-like 3

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue81N6-acetyllysine By similarity
Modified residue251N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q08093 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 91DCDB47BEED53F8

FASTA30533,156
        10         20         30         40         50         60 
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRSWIEG LTGLSIGPDF QKGLKDGVIL 

        70         80         90        100        110        120 
CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV 

       130        140        150        160        170        180 
QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ ERNFDDATMK AGQCVIGLQM GTNKCASQSG 

       190        200        210        220        230        240 
MTAYGTRRHL YDPKNHILPP MDHCTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC 

       250        260        270        280        290        300 
DNSSMSLQMG YTQGANQSGQ VFGLGRQIYD PKYCPQGSAA DGAPAGDGQG EAPEYLAYCQ 


EEAGY

« Hide

References

« Hide 'large scale' references
[1]"Mammalian calponin. Identification and expression of genetic variants."
Strasser P., Gimona M., Moessler H., Herzog M., Small J.V.
FEBS Lett. 330:13-18(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Smooth muscle.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II and FVB/N.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z19543 mRNA. Translation: CAA79603.1.
BC009144 mRNA. Translation: AAH09144.1.
BC018482 mRNA. Translation: AAH18482.1.
IPIIPI00116649.
PIRS31485. S36147.
RefSeqNP_031751.1. NM_007725.2.
UniGeneMm.157770.

3D structure databases

ProteinModelPortalQ08093.
SMRQ08093. Positions 13-153.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000004784.

PTM databases

PhosphoSiteQ08093.

Proteomic databases

PaxDbQ08093.
PRIDEQ08093.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000004784; ENSMUSP00000004784; ENSMUSG00000004665.
GeneID12798.
KEGGmmu:12798.

Organism-specific databases

CTD1265.
MGIMGI:105093. Cnn2.

Phylogenomic databases

eggNOGCOG5199.
HOGENOMHOG000232113.
HOVERGENHBG005186.
InParanoidQ08093.
OMACPQGPAA.
OrthoDBEOG49W2G2.

Gene expression databases

ArrayExpressQ08093.
BgeeQ08093.
CleanExMM_CNN2.
GenevestigatorQ08093.
GermOnlineENSMUSG00000004665. Mus musculus.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
InterProIPR001997. Calponin.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTSM00033. CH. 1 hit.
[Graphical view]
SUPFAMSSF47576. Calponin-homology. 1 hit.
PROSITEPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCNN2. mouse.
NextBio282218.
SOURCESearch...

Entry information

Entry nameCNN2_MOUSE
AccessionPrimary (citable) accession number: Q08093
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 3, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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