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Q08078

- CP2CP_MESAU

UniProt

Q08078 - CP2CP_MESAU

Protein

Cytochrome P450 2C25

Gene

CYP2C25

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine. Also has testosterone hydroxylase (16 beta) activity.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C25 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC25
    Cytochrome P450 HSM1
    Gene namesi
    Name:CYP2C25
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C25PRO_0000051713Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08078.
    SMRiQ08078. Positions 30-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08078-1 [UniParc]FASTAAdd to Basket

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    MDAVLVLVFI LSSLVFLSLW RQSSERRKLP PGPTPLPIIG NFLQIDVKNI    50
    SGSLTNFSKV YGPVFTLYLG MKPTVVLHGY ETVKEALIDH GEEFAGRGDF 100
    PMAERINKGL GIVFSNGNRW KEIRRFSLMT LRNLGMGKRN IEDRVQEEAQ 150
    CLVEELRKTN GSPCDPTFIL SCAPCNVICS IIFQNRFDYK DQDFLTFMKK 200
    VNENVRILSS PWLQVCNNFP SLIDYCPGSH HKITKNVNYL KKYILEKIEE 250
    HQESLDIENP RDFIDYYLIK LKQANHNQQS EFSLENLTTT VSDLFGAGTE 300
    TTSTTLRYAL LLLLKHPHVT AKVQEEIDQV VGRHRKPCMQ DRSHMPYTDA 350
    MIHEVQRFID LIPISLPHAV TCDIKFRDYF IPKGTTVITS LSSVLHDNKE 400
    FPNPEVFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT 450
    TILQNFKLKS MIHPKDIDTT PVVNGFASLP PSYQLCFIPV 490
    Length:490
    Mass (Da):55,967
    Last modified:November 1, 1996 - v1
    Checksum:iAB040B2ECAB80453
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63022 mRNA. Translation: CAA44753.1.
    PIRiI48189.
    RefSeqiNP_001268615.1. NM_001281686.1.

    Genome annotation databases

    GeneIDi101823450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63022 mRNA. Translation: CAA44753.1 .
    PIRi I48189.
    RefSeqi NP_001268615.1. NM_001281686.1.

    3D structure databases

    ProteinModelPortali Q08078.
    SMRi Q08078. Positions 30-490.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101823450.

    Phylogenomic databases

    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs."
      Sakuma T., Masaki K., Itoh S., Yokoi T., Kamataki T.
      Mol. Pharmacol. 45:228-236(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2CP_MESAU
    AccessioniPrimary (citable) accession number: Q08078
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3