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Q08078 (CP2CP_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C25

EC=1.14.14.1
Alternative name(s):
CYPIIC25
Cytochrome P450 HSM1
Gene names
Name:CYP2C25
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine. Also has testosterone hydroxylase (16 beta) activity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C25
PRO_0000051713

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q08078 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AB040B2ECAB80453

FASTA49055,967
        10         20         30         40         50         60 
MDAVLVLVFI LSSLVFLSLW RQSSERRKLP PGPTPLPIIG NFLQIDVKNI SGSLTNFSKV 

        70         80         90        100        110        120 
YGPVFTLYLG MKPTVVLHGY ETVKEALIDH GEEFAGRGDF PMAERINKGL GIVFSNGNRW 

       130        140        150        160        170        180 
KEIRRFSLMT LRNLGMGKRN IEDRVQEEAQ CLVEELRKTN GSPCDPTFIL SCAPCNVICS 

       190        200        210        220        230        240 
IIFQNRFDYK DQDFLTFMKK VNENVRILSS PWLQVCNNFP SLIDYCPGSH HKITKNVNYL 

       250        260        270        280        290        300 
KKYILEKIEE HQESLDIENP RDFIDYYLIK LKQANHNQQS EFSLENLTTT VSDLFGAGTE 

       310        320        330        340        350        360 
TTSTTLRYAL LLLLKHPHVT AKVQEEIDQV VGRHRKPCMQ DRSHMPYTDA MIHEVQRFID 

       370        380        390        400        410        420 
LIPISLPHAV TCDIKFRDYF IPKGTTVITS LSSVLHDNKE FPNPEVFDPG HFLDKNGNFK 

       430        440        450        460        470        480 
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFKLKS MIHPKDIDTT PVVNGFASLP 

       490 
PSYQLCFIPV 

« Hide

References

[1]"Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs."
Sakuma T., Masaki K., Itoh S., Yokoi T., Kamataki T.
Mol. Pharmacol. 45:228-236(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63022 mRNA. Translation: CAA44753.1.
PIRI48189.
RefSeqNP_001268615.1. NM_001281686.1.

3D structure databases

ProteinModelPortalQ08078.
SMRQ08078. Positions 30-490.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101823450.

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CP_MESAU
AccessionPrimary (citable) accession number: Q08078
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families