Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q08078

- CP2CP_MESAU

UniProt

Q08078 - CP2CP_MESAU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome P450 2C25

Gene

CYP2C25

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine. Also has testosterone hydroxylase (16 beta) activity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C25 (EC:1.14.14.1)
Alternative name(s):
CYPIIC25
Cytochrome P450 HSM1
Gene namesi
Name:CYP2C25
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C25PRO_0000051713Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliQ08078.
SMRiQ08078. Positions 30-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08078 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAVLVLVFI LSSLVFLSLW RQSSERRKLP PGPTPLPIIG NFLQIDVKNI
60 70 80 90 100
SGSLTNFSKV YGPVFTLYLG MKPTVVLHGY ETVKEALIDH GEEFAGRGDF
110 120 130 140 150
PMAERINKGL GIVFSNGNRW KEIRRFSLMT LRNLGMGKRN IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL SCAPCNVICS IIFQNRFDYK DQDFLTFMKK
210 220 230 240 250
VNENVRILSS PWLQVCNNFP SLIDYCPGSH HKITKNVNYL KKYILEKIEE
260 270 280 290 300
HQESLDIENP RDFIDYYLIK LKQANHNQQS EFSLENLTTT VSDLFGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKHPHVT AKVQEEIDQV VGRHRKPCMQ DRSHMPYTDA
360 370 380 390 400
MIHEVQRFID LIPISLPHAV TCDIKFRDYF IPKGTTVITS LSSVLHDNKE
410 420 430 440 450
FPNPEVFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT
460 470 480 490
TILQNFKLKS MIHPKDIDTT PVVNGFASLP PSYQLCFIPV
Length:490
Mass (Da):55,967
Last modified:November 1, 1996 - v1
Checksum:iAB040B2ECAB80453
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63022 mRNA. Translation: CAA44753.1.
PIRiI48189.
RefSeqiNP_001268615.1. NM_001281686.1.

Genome annotation databases

GeneIDi101823450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63022 mRNA. Translation: CAA44753.1 .
PIRi I48189.
RefSeqi NP_001268615.1. NM_001281686.1.

3D structure databases

ProteinModelPortali Q08078.
SMRi Q08078. Positions 30-490.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101823450.

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs."
    Sakuma T., Masaki K., Itoh S., Yokoi T., Kamataki T.
    Mol. Pharmacol. 45:228-236(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2CP_MESAU
AccessioniPrimary (citable) accession number: Q08078
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3