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Q08078

- CP2CP_MESAU

UniProt

Q08078 - CP2CP_MESAU

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Protein

Cytochrome P450 2C25

Gene
CYP2C25
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine. Also has testosterone hydroxylase (16 beta) activity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C25 (EC:1.14.14.1)
Alternative name(s):
CYPIIC25
Cytochrome P450 HSM1
Gene namesi
Name:CYP2C25
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C25PRO_0000051713Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliQ08078.
SMRiQ08078. Positions 30-490.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08078-1 [UniParc]FASTAAdd to Basket

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MDAVLVLVFI LSSLVFLSLW RQSSERRKLP PGPTPLPIIG NFLQIDVKNI    50
SGSLTNFSKV YGPVFTLYLG MKPTVVLHGY ETVKEALIDH GEEFAGRGDF 100
PMAERINKGL GIVFSNGNRW KEIRRFSLMT LRNLGMGKRN IEDRVQEEAQ 150
CLVEELRKTN GSPCDPTFIL SCAPCNVICS IIFQNRFDYK DQDFLTFMKK 200
VNENVRILSS PWLQVCNNFP SLIDYCPGSH HKITKNVNYL KKYILEKIEE 250
HQESLDIENP RDFIDYYLIK LKQANHNQQS EFSLENLTTT VSDLFGAGTE 300
TTSTTLRYAL LLLLKHPHVT AKVQEEIDQV VGRHRKPCMQ DRSHMPYTDA 350
MIHEVQRFID LIPISLPHAV TCDIKFRDYF IPKGTTVITS LSSVLHDNKE 400
FPNPEVFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT 450
TILQNFKLKS MIHPKDIDTT PVVNGFASLP PSYQLCFIPV 490
Length:490
Mass (Da):55,967
Last modified:November 1, 1996 - v1
Checksum:iAB040B2ECAB80453
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63022 mRNA. Translation: CAA44753.1.
PIRiI48189.
RefSeqiNP_001268615.1. NM_001281686.1.

Genome annotation databases

GeneIDi101823450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63022 mRNA. Translation: CAA44753.1 .
PIRi I48189.
RefSeqi NP_001268615.1. NM_001281686.1.

3D structure databases

ProteinModelPortali Q08078.
SMRi Q08078. Positions 30-490.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101823450.

Phylogenomic databases

HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs."
    Sakuma T., Masaki K., Itoh S., Yokoi T., Kamataki T.
    Mol. Pharmacol. 45:228-236(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2CP_MESAU
AccessioniPrimary (citable) accession number: Q08078
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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