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Q08062

- MDHC_MAIZE

UniProt

Q08062 - MDHC_MAIZE

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Protein

Malate dehydrogenase, cytoplasmic

Gene
N/A
Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931Substrate By similarity
Binding sitei99 – 991Substrate By similarity
Binding sitei106 – 1061NAD By similarity
Binding sitei113 – 1131NAD By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei163 – 1631Substrate By similarity
Active sitei188 – 1881Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 187NAD By similarity
Nucleotide bindingi130 – 1323NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. response to cadmium ion Source: EnsemblPlants/Gramene
  4. response to salt stress Source: EnsemblPlants/Gramene
  5. response to zinc ion Source: EnsemblPlants/Gramene
  6. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, cytoplasmic (EC:1.1.1.37)
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiQ08062.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. apoplast Source: EnsemblPlants/Gramene
  2. chloroplast stroma Source: EnsemblPlants/Gramene
  3. cytosol Source: EnsemblPlants/Gramene
  4. nucleus Source: EnsemblPlants/Gramene
  5. plasma membrane Source: EnsemblPlants/Gramene
  6. plasmodesma Source: EnsemblPlants/Gramene
  7. vacuolar membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Malate dehydrogenase, cytoplasmicPRO_0000113415Add
BLAST

Proteomic databases

PRIDEiQ08062.
ProMEXiQ08062.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ08062.
SMRiQ08062. Positions 4-331.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220953.
KOiK00025.
OMAiNCLIASK.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR011274. Malate_DH_NAD-dep_euk.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
TIGR01758. MDH_euk_cyt. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08062-1 [UniParc]FASTAAdd to Basket

« Hide

MAKEPMRVLV TGAAGQIGYA LVPMIARGVM LGADQPVILH MLDIPPAAEA    50
LNGVKMELVD AAFPLLKGVV ATTDVVEACT GVNVAVMVGG FPRKEGMERK 100
DVMSKNVSIY KSQASALEAH AAPNCKVLVV ANPANTNALI LKEFAPSIPE 150
KNVTCLTRLD HNRALGQISE RLNVQVSDVK NVIIWGNHSS SQYPDVNHAT 200
VKTSTGEKPV RELVSDDEWL NGEFITTVQQ RGAAIIKARK FSSALSAASS 250
ACDHIRDWVL GTPEGTFVSM GVYSDGSYGV PSGLIYSFPV TCSGGEWKIV 300
QGLPIDEFSR KKMDATAQEL TEEKTLAYSC LE 332
Length:332
Mass (Da):35,590
Last modified:November 1, 1998 - v2
Checksum:i05D82B33FF0CE26F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007581 mRNA. Translation: AAB64290.1.
M95069 mRNA. Translation: AAA18556.2.
PIRiT02935.
T03650.
RefSeqiNP_001105603.1. NM_001112133.1.
UniGeneiZm.103385.
Zm.82624.

Genome annotation databases

GeneIDi542598.
KEGGizma:542598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007581 mRNA. Translation: AAB64290.1 .
M95069 mRNA. Translation: AAA18556.2 .
PIRi T02935.
T03650.
RefSeqi NP_001105603.1. NM_001112133.1.
UniGenei Zm.103385.
Zm.82624.

3D structure databases

ProteinModelPortali Q08062.
SMRi Q08062. Positions 4-331.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q08062.
ProMEXi Q08062.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 542598.
KEGGi zma:542598.

Organism-specific databases

Gramenei Q08062.

Phylogenomic databases

HOGENOMi HOG000220953.
KOi K00025.
OMAi NCLIASK.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR011274. Malate_DH_NAD-dep_euk.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
TIGR01758. MDH_euk_cyt. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of cytoplasmic malate dehydrogenase over-expressed in hybrid maize."
    Hu J., Zhao X., Yuan Z., Qian X., Yang J.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Yedan 4.
    Tissue: Leaf.
  2. "Partial sequence analysis of 130 randomly selected maize cDNA clones."
    Keith C.S., Hoang D.O., Barrett B.M., Feigelman B., Nelson M.C., Thai H., Baysdorfer C.
    Plant Physiol. 101:329-332(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-73.
    Tissue: Leaf and Sheath.

Entry informationi

Entry nameiMDHC_MAIZE
AccessioniPrimary (citable) accession number: Q08062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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