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Q08058

- COQ10_YEAST

UniProt

Q08058 - COQ10_YEAST

Protein

Coenzyme Q-binding protein COQ10, mitochondrial

Gene

COQ10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.1 Publication

    GO - Molecular functioni

    1. ubiquinone binding Source: SGD

    GO - Biological processi

    1. cellular respiration Source: SGD
    2. ubiquinone biosynthetic process Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33425-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coenzyme Q-binding protein COQ10, mitochondrial
    Gene namesi
    Name:COQ10
    Ordered Locus Names:YOL008W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOL008w.
    SGDiS000005368. COQ10.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 207168Coenzyme Q-binding protein COQ10, mitochondrialPRO_0000227688Add
    BLAST

    Proteomic databases

    MaxQBiQ08058.
    PaxDbiQ08058.

    Expressioni

    Gene expression databases

    GenevestigatoriQ08058.

    Interactioni

    Subunit structurei

    Interacts with coenzyme Q.1 Publication

    Protein-protein interaction databases

    BioGridi34396. 56 interactions.
    DIPiDIP-4689N.
    MINTiMINT-483249.
    STRINGi4932.YOL008W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ08058.
    SMRiQ08058. Positions 44-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COQ10 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2867.
    HOGENOMiHOG000000776.
    OMAiLRFKFKS.
    OrthoDBiEOG7WHHP9.

    Family and domain databases

    Gene3Di3.30.530.20. 1 hit.
    InterProiIPR005031. Polyket_cyc.
    IPR023393. START-like_dom.
    [Graphical view]
    PfamiPF03364. Polyketide_cyc. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q08058-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLIIRPSQT LILFRKAMLK PIGRYPLKRN FFGLSGTNHT IREQRYVLRK    50
    AINAPPSTVY AAVSEVAQYK EFIPYCVDSF VDKRNPVDNK PLIAGLRVGF 100
    KQYDEEFICN VTCKDTDHTY TVVAETISHN LFHLLISKWT IMPHPNRPNA 150
    AMVELLLRFK FKSRIYNSVS LIFAKTVTEL VMNAFAKRAY HLVRLAMLKP 200
    SSKEGSP 207
    Length:207
    Mass (Da):23,765
    Last modified:November 1, 1996 - v1
    Checksum:i8A9F5D48159CC519
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74750 Genomic DNA. Translation: CAA99007.1.
    AY558008 Genomic DNA. Translation: AAS56334.1.
    BK006948 Genomic DNA. Translation: DAA10775.1.
    PIRiS66690.
    RefSeqiNP_014635.1. NM_001183262.1.

    Genome annotation databases

    EnsemblFungiiYOL008W; YOL008W; YOL008W.
    GeneIDi854154.
    KEGGisce:YOL008W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74750 Genomic DNA. Translation: CAA99007.1 .
    AY558008 Genomic DNA. Translation: AAS56334.1 .
    BK006948 Genomic DNA. Translation: DAA10775.1 .
    PIRi S66690.
    RefSeqi NP_014635.1. NM_001183262.1.

    3D structure databases

    ProteinModelPortali Q08058.
    SMRi Q08058. Positions 44-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34396. 56 interactions.
    DIPi DIP-4689N.
    MINTi MINT-483249.
    STRINGi 4932.YOL008W.

    Proteomic databases

    MaxQBi Q08058.
    PaxDbi Q08058.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOL008W ; YOL008W ; YOL008W .
    GeneIDi 854154.
    KEGGi sce:YOL008W.

    Organism-specific databases

    CYGDi YOL008w.
    SGDi S000005368. COQ10.

    Phylogenomic databases

    eggNOGi COG2867.
    HOGENOMi HOG000000776.
    OMAi LRFKFKS.
    OrthoDBi EOG7WHHP9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33425-MONOMER.

    Miscellaneous databases

    NextBioi 975914.
    PROi Q08058.

    Gene expression databases

    Genevestigatori Q08058.

    Family and domain databases

    Gene3Di 3.30.530.20. 1 hit.
    InterProi IPR005031. Polyket_cyc.
    IPR023393. START-like_dom.
    [Graphical view ]
    Pfami PF03364. Polyketide_cyc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration."
      Barros M.H., Johnson A., Gin P., Marbois B.N., Clarke C.F., Tzagoloff A.
      J. Biol. Chem. 280:42627-42635(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COENZYME Q.

    Entry informationi

    Entry nameiCOQ10_YEAST
    AccessioniPrimary (citable) accession number: Q08058
    Secondary accession number(s): D6W259
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3