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Q08058 (COQ10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coenzyme Q-binding protein COQ10, mitochondrial
Gene names
Name:COQ10
Ordered Locus Names:YOL008W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. Ref.4

Subunit structure

Interacts with coenzyme Q. Ref.4

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side Ref.4.

Sequence similarities

Belongs to the COQ10 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 207168Coenzyme Q-binding protein COQ10, mitochondrial
PRO_0000227688

Sequences

Sequence LengthMass (Da)Tools
Q08058 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8A9F5D48159CC519

FASTA20723,765
        10         20         30         40         50         60 
MVLIIRPSQT LILFRKAMLK PIGRYPLKRN FFGLSGTNHT IREQRYVLRK AINAPPSTVY 

        70         80         90        100        110        120 
AAVSEVAQYK EFIPYCVDSF VDKRNPVDNK PLIAGLRVGF KQYDEEFICN VTCKDTDHTY 

       130        140        150        160        170        180 
TVVAETISHN LFHLLISKWT IMPHPNRPNA AMVELLLRFK FKSRIYNSVS LIFAKTVTEL 

       190        200 
VMNAFAKRAY HLVRLAMLKP SSKEGSP 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration."
Barros M.H., Johnson A., Gin P., Marbois B.N., Clarke C.F., Tzagoloff A.
J. Biol. Chem. 280:42627-42635(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COENZYME Q.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z74750 Genomic DNA. Translation: CAA99007.1.
AY558008 Genomic DNA. Translation: AAS56334.1.
BK006948 Genomic DNA. Translation: DAA10775.1.
PIRS66690.
RefSeqNP_014635.1. NM_001183262.1.

3D structure databases

ProteinModelPortalQ08058.
SMRQ08058. Positions 44-195.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34396. 56 interactions.
DIPDIP-4689N.
MINTMINT-483249.
STRING4932.YOL008W.

Proteomic databases

PaxDbQ08058.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOL008W; YOL008W; YOL008W.
GeneID854154.
KEGGsce:YOL008W.

Organism-specific databases

CYGDYOL008w.
SGDS000005368. COQ10.

Phylogenomic databases

eggNOGCOG2867.
HOGENOMHOG000000776.
OMAMINSFDK.
OrthoDBEOG7WHHP9.

Enzyme and pathway databases

BioCycYEAST:G3O-33425-MONOMER.

Gene expression databases

GenevestigatorQ08058.

Family and domain databases

Gene3D3.30.530.20. 1 hit.
InterProIPR005031. Polyket_cyc.
IPR023393. START-like_dom.
[Graphical view]
PfamPF03364. Polyketide_cyc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975914.
PROQ08058.

Entry information

Entry nameCOQ10_YEAST
AccessionPrimary (citable) accession number: Q08058
Secondary accession number(s): D6W259
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families