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Q08058

- COQ10_YEAST

UniProt

Q08058 - COQ10_YEAST

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Protein

Coenzyme Q-binding protein COQ10, mitochondrial

Gene

COQ10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.1 Publication

GO - Molecular functioni

  1. ubiquinone binding Source: SGD

GO - Biological processi

  1. cellular respiration Source: SGD
  2. ubiquinone biosynthetic process Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33425-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme Q-binding protein COQ10, mitochondrial
Gene namesi
Name:COQ10
Ordered Locus Names:YOL008W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOL008w.
SGDiS000005368. COQ10.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 207168Coenzyme Q-binding protein COQ10, mitochondrialPRO_0000227688Add
BLAST

Proteomic databases

MaxQBiQ08058.
PaxDbiQ08058.

Expressioni

Gene expression databases

GenevestigatoriQ08058.

Interactioni

Subunit structurei

Interacts with coenzyme Q.1 Publication

Protein-protein interaction databases

BioGridi34396. 58 interactions.
DIPiDIP-4689N.
MINTiMINT-483249.
STRINGi4932.YOL008W.

Structurei

3D structure databases

ProteinModelPortaliQ08058.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ10 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG2867.
HOGENOMiHOG000000776.
InParanoidiQ08058.
KOiK18588.
OMAiLRFKFKS.
OrthoDBiEOG7WHHP9.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR005031. Polyket_cyc.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF03364. Polyketide_cyc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08058-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLIIRPSQT LILFRKAMLK PIGRYPLKRN FFGLSGTNHT IREQRYVLRK
60 70 80 90 100
AINAPPSTVY AAVSEVAQYK EFIPYCVDSF VDKRNPVDNK PLIAGLRVGF
110 120 130 140 150
KQYDEEFICN VTCKDTDHTY TVVAETISHN LFHLLISKWT IMPHPNRPNA
160 170 180 190 200
AMVELLLRFK FKSRIYNSVS LIFAKTVTEL VMNAFAKRAY HLVRLAMLKP

SSKEGSP
Length:207
Mass (Da):23,765
Last modified:November 1, 1996 - v1
Checksum:i8A9F5D48159CC519
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74750 Genomic DNA. Translation: CAA99007.1.
AY558008 Genomic DNA. Translation: AAS56334.1.
BK006948 Genomic DNA. Translation: DAA10775.1.
PIRiS66690.
RefSeqiNP_014635.1. NM_001183262.1.

Genome annotation databases

EnsemblFungiiYOL008W; YOL008W; YOL008W.
GeneIDi854154.
KEGGisce:YOL008W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74750 Genomic DNA. Translation: CAA99007.1 .
AY558008 Genomic DNA. Translation: AAS56334.1 .
BK006948 Genomic DNA. Translation: DAA10775.1 .
PIRi S66690.
RefSeqi NP_014635.1. NM_001183262.1.

3D structure databases

ProteinModelPortali Q08058.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34396. 58 interactions.
DIPi DIP-4689N.
MINTi MINT-483249.
STRINGi 4932.YOL008W.

Proteomic databases

MaxQBi Q08058.
PaxDbi Q08058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOL008W ; YOL008W ; YOL008W .
GeneIDi 854154.
KEGGi sce:YOL008W.

Organism-specific databases

CYGDi YOL008w.
SGDi S000005368. COQ10.

Phylogenomic databases

eggNOGi COG2867.
HOGENOMi HOG000000776.
InParanoidi Q08058.
KOi K18588.
OMAi LRFKFKS.
OrthoDBi EOG7WHHP9.

Enzyme and pathway databases

BioCyci YEAST:G3O-33425-MONOMER.

Miscellaneous databases

NextBioi 975914.
PROi Q08058.

Gene expression databases

Genevestigatori Q08058.

Family and domain databases

Gene3Di 3.30.530.20. 1 hit.
InterProi IPR005031. Polyket_cyc.
IPR023393. START-like_dom.
[Graphical view ]
Pfami PF03364. Polyketide_cyc. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration."
    Barros M.H., Johnson A., Gin P., Marbois B.N., Clarke C.F., Tzagoloff A.
    J. Biol. Chem. 280:42627-42635(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COENZYME Q.

Entry informationi

Entry nameiCOQ10_YEAST
AccessioniPrimary (citable) accession number: Q08058
Secondary accession number(s): D6W259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3