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Protein

Coenzyme Q-binding protein COQ10, mitochondrial

Gene

COQ10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.1 Publication

GO - Molecular functioni

  • ubiquinone binding Source: SGD

GO - Biological processi

  • cellular respiration Source: SGD
  • ubiquinone biosynthetic process Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33425-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme Q-binding protein COQ10, mitochondrial
Gene namesi
Name:COQ10
Ordered Locus Names:YOL008W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL008W
SGDiS000005368 COQ10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000022768840 – 207Coenzyme Q-binding protein COQ10, mitochondrialAdd BLAST168

Proteomic databases

MaxQBiQ08058
PaxDbiQ08058
PRIDEiQ08058

Interactioni

Subunit structurei

Interacts with coenzyme Q.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NHP2P324953EBI-38194,EBI-12014

Protein-protein interaction databases

BioGridi34396, 217 interactors
DIPiDIP-4689N
IntActiQ08058, 1 interactor
MINTiQ08058
STRINGi4932.YOL008W

Structurei

3D structure databases

ProteinModelPortaliQ08058
SMRiQ08058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ10 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000000776
InParanoidiQ08058
KOiK18588
OMAiRKVVSGC
OrthoDBiEOG092C554R

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR005031 COQ10_START
IPR023393 START-like_dom_sf
PfamiView protein in Pfam
PF03364 Polyketide_cyc, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q08058-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLIIRPSQT LILFRKAMLK PIGRYPLKRN FFGLSGTNHT IREQRYVLRK
60 70 80 90 100
AINAPPSTVY AAVSEVAQYK EFIPYCVDSF VDKRNPVDNK PLIAGLRVGF
110 120 130 140 150
KQYDEEFICN VTCKDTDHTY TVVAETISHN LFHLLISKWT IMPHPNRPNA
160 170 180 190 200
AMVELLLRFK FKSRIYNSVS LIFAKTVTEL VMNAFAKRAY HLVRLAMLKP

SSKEGSP
Length:207
Mass (Da):23,765
Last modified:November 1, 1996 - v1
Checksum:i8A9F5D48159CC519
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74750 Genomic DNA Translation: CAA99007.1
AY558008 Genomic DNA Translation: AAS56334.1
BK006948 Genomic DNA Translation: DAA10775.1
PIRiS66690
RefSeqiNP_014635.1, NM_001183262.1

Genome annotation databases

EnsemblFungiiYOL008W; YOL008W; YOL008W
GeneIDi854154
KEGGisce:YOL008W

Similar proteinsi

Entry informationi

Entry nameiCOQ10_YEAST
AccessioniPrimary (citable) accession number: Q08058
Secondary accession number(s): D6W259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health