Q08058 (COQ10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coenzyme Q-binding protein COQ10, mitochondrial

Gene names

Name:	COQ10
Ordered Locus Names:	YOL008W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. Ref.4
Subunit structure	Interacts with coenzyme Q. Ref.4
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side Ref.4.
Sequence similarities	Belongs to the COQ10 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular respiration Inferred from mutant phenotype PubMed 23270816PubMed 50596. Source: SGD ubiquinone biosynthetic process Inferred from mutant phenotype PubMed 23270816. Source: SGD
Cellular_component	mitochondrial inner membrane Inferred from direct assay Ref.4. Source: SGD
Molecular_function	ubiquinone binding Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 39	39	Mitochondrion Potential
	Chain	40 – 207	168	Coenzyme Q-binding protein COQ10, mitochondrial		PRO_0000227688

Sequences

	Sequence		Length	Mass (Da)
	Q08058 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8A9F5D48159CC519	FASTA	207	23,765
	10 20 30 40 50 60 MVLIIRPSQT LILFRKAMLK PIGRYPLKRN FFGLSGTNHT IREQRYVLRK AINAPPSTVY 70 80 90 100 110 120 AAVSEVAQYK EFIPYCVDSF VDKRNPVDNK PLIAGLRVGF KQYDEEFICN VTCKDTDHTY 130 140 150 160 170 180 TVVAETISHN LFHLLISKWT IMPHPNRPNA AMVELLLRFK FKSRIYNSVS LIFAKTVTEL 190 200 VMNAFAKRAY HLVRLAMLKP SSKEGSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration." Barros M.H., Johnson A., Gin P., Marbois B.N., Clarke C.F., Tzagoloff A. J. Biol. Chem. 280:42627-42635(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH COENZYME Q.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z74750 Genomic DNA. Translation: CAA99007.1. AY558008 Genomic DNA. Translation: AAS56334.1. BK006948 Genomic DNA. Translation: DAA10775.1.
PIR	S66690.
RefSeq	NP_014635.1. NM_001183262.1.
3D structure databases
ProteinModelPortal	Q08058.
SMR	Q08058. Positions 44-195.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4689N.
MINT	MINT-483249.
STRING	4932.YOL008W.
Proteomic databases
PaxDb	Q08058.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOL008W; YOL008W; YOL008W.
GeneID	854154.
KEGG	sce:YOL008W.
Organism-specific databases
CYGD	YOL008w.
SGD	S000005368. COQ10.
Phylogenomic databases
eggNOG	COG2867.
HOGENOM	HOG000000776.
OMA	RIIRCHE.
OrthoDB	EOG425936.
Gene expression databases
Genevestigator	Q08058.
GermOnline	YOL008W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.30.530.20. 1 hit.
InterPro	IPR005031. Polyket_cyc. IPR023393. START-like_dom. [Graphical view]
Pfam	PF03364. Polyketide_cyc. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	975914.

Entry information

Entry name

COQ10_YEAST

Accession

Primary (citable) accession number: Q08058
Secondary accession number(s): D6W259

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program