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Q08048

- HGF_MOUSE

UniProt

Q08048 - HGF_MOUSE

Protein

Hepatocyte growth factor

Gene

Hgf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.1 Publication

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. cell chemotaxis Source: Ensembl
    3. cell morphogenesis Source: MGI
    4. cell proliferation Source: MGI
    5. cellular response to hepatocyte growth factor stimulus Source: Ensembl
    6. hepatocyte growth factor receptor signaling pathway Source: MGI
    7. hyaluronan metabolic process Source: Ensembl
    8. liver development Source: MGI
    9. myoblast proliferation Source: MGI
    10. negative regulation of apoptotic process Source: Ensembl
    11. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    12. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    13. negative regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
    14. negative regulation of release of cytochrome c from mitochondria Source: Ensembl
    15. organ regeneration Source: Ensembl
    16. positive regulation of cell migration Source: Ensembl
    17. positive regulation of DNA biosynthetic process Source: Ensembl
    18. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    19. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    20. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI

    Keywords - Molecular functioni

    Growth factor, Serine protease homolog

    Enzyme and pathway databases

    ReactomeiREACT_198701. Interleukin-7 signaling.

    Protein family/group databases

    MEROPSiS01.982.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hepatocyte growth factor
    Alternative name(s):
    Hepatopoietin-A
    Scatter factor
    Short name:
    SF
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Hgf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:96079. Hgf.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232By similarityAdd
    BLAST
    Chaini33 – 495463Hepatocyte growth factor alpha chainPRO_0000028093Add
    BLAST
    Chaini496 – 728233Hepatocyte growth factor beta chainPRO_0000028094Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi71 ↔ 97
    Disulfide bondi75 ↔ 85
    Disulfide bondi129 ↔ 207
    Disulfide bondi150 ↔ 190
    Disulfide bondi178 ↔ 202
    Disulfide bondi212 ↔ 289By similarity
    Disulfide bondi233 ↔ 272By similarity
    Disulfide bondi261 ↔ 284By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi306 ↔ 384By similarity
    Disulfide bondi327 ↔ 366By similarity
    Disulfide bondi355 ↔ 378By similarity
    Disulfide bondi392 ↔ 470By similarity
    Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi413 ↔ 453By similarity
    Disulfide bondi441 ↔ 465By similarity
    Disulfide bondi488 ↔ 607Interchain (between alpha and beta chains)PROSITE-ProRule annotation
    Disulfide bondi520 ↔ 536By similarity
    Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi615 ↔ 682By similarity
    Disulfide bondi645 ↔ 661By similarity
    Glycosylationi656 – 6561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi672 ↔ 700By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiQ08048.

    PTM databases

    PhosphoSiteiQ08048.

    Expressioni

    Gene expression databases

    BgeeiQ08048.
    CleanExiMM_HGF.
    GenevestigatoriQ08048.

    Interactioni

    Subunit structurei

    Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

    Protein-protein interaction databases

    DIPiDIP-46456N.

    Structurei

    Secondary structure

    1
    728
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi40 – 423
    Beta strandi43 – 5210
    Beta strandi55 – 573
    Beta strandi61 – 644
    Helixi68 – 7710
    Turni78 – 803
    Beta strandi87 – 915
    Turni92 – 954
    Beta strandi96 – 1016
    Beta strandi106 – 1083
    Beta strandi110 – 12213
    Helixi123 – 1253
    Beta strandi129 – 1335
    Beta strandi149 – 1513
    Beta strandi157 – 1593
    Turni165 – 1673
    Beta strandi188 – 1947
    Beta strandi198 – 2014
    Turni207 – 2093
    Beta strandi240 – 2423
    Helixi248 – 2503
    Turni252 – 2554
    Beta strandi271 – 2755
    Beta strandi280 – 2834

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QJ4X-ray2.50A/B29-210[»]
    3HMRX-ray2.00A31-127[»]
    4IUAX-ray3.05A/B/C/D/E/F/G/H31-290[»]
    ProteinModelPortaliQ08048.
    SMRiQ08048. Positions 37-476, 496-724.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ08048.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 12487PANPROSITE-ProRule annotationAdd
    BLAST
    Domaini129 – 20779Kringle 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini212 – 28978Kringle 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini306 – 38479Kringle 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini392 – 47079Kringle 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 724229Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation
    Contains 4 kringle domains.PROSITE-ProRule annotation
    Contains 1 PAN domain.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Kringle, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00740000115022.
    HOGENOMiHOG000112892.
    HOVERGENiHBG004381.
    InParanoidiQ08048.
    KOiK05460.
    OMAiGSESPWC.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ08048.
    TreeFamiTF329901.

    Family and domain databases

    Gene3Di2.40.20.10. 4 hits.
    InterProiIPR027284. Hepatocyte_GF.
    IPR024174. HGF_MST1.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00051. Kringle. 4 hits.
    PF00024. PAN_1. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500183. Hepatocyte_GF. 1 hit.
    PIRSF001152. HGF_MST1. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00130. KR. 4 hits.
    SM00473. PAN_AP. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 4 hits.
    PROSITEiPS00021. KRINGLE_1. 4 hits.
    PS50070. KRINGLE_2. 4 hits.
    PS50948. PAN. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q08048-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT    50
    LTKEDPLLKI KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY 100
    PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC 150
    QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE 200
    VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER 250
    YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKTCA HSAVNETDVP 300
    METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL 350
    RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY 400
    MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLNKNY CRNPDDDAHG 450
    PWCYTGNPLI PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLRVVNGI 500
    PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR NKDLKDYEAW 550
    LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI 600
    DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ 650
    GKVTLNESEL CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC 700
    AIPNRPGIFV RVAYYAKWIH KVILTYKL 728
    Length:728
    Mass (Da):82,945
    Last modified:November 1, 1995 - v1
    Checksum:iA0381FC497534328
    GO
    Isoform Short (identifier: Q08048-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         163-167: Missing.

    Show »
    Length:723
    Mass (Da):82,413
    Checksum:i7BC19A16C399EDD2
    GO
    Isoform NK1 (identifier: Q08048-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         210-211: VE → GK
         212-728: Missing.

    Show »
    Length:211
    Mass (Da):24,308
    Checksum:i758BD0687A835F48
    GO

    Sequence cautioni

    The sequence CAA51054.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti189 – 1891W → K AA sequence (PubMed:2144630)Curated
    Sequence conflicti344 – 3441N → K in AAB31855. (PubMed:8081873)Curated
    Sequence conflicti378 – 3781C → E AA sequence (PubMed:2144630)Curated
    Sequence conflicti380 – 3801Q → E AA sequence (PubMed:2144630)Curated
    Sequence conflicti479 – 4791V → L in AAB31855. (PubMed:8081873)Curated
    Sequence conflicti513 – 5131K → L AA sequence (PubMed:2142751)Curated
    Sequence conflicti518 – 5181H → T AA sequence (PubMed:1831975)Curated
    Sequence conflicti564 – 5641R → H in CAA51054. (PubMed:8241272)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei163 – 1675Missing in isoform Short. 1 PublicationVSP_005408
    Alternative sequencei210 – 2112VE → GK in isoform NK1. 1 PublicationVSP_044345
    Alternative sequencei212 – 728517Missing in isoform NK1. 1 PublicationVSP_044346Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10212 mRNA. Translation: BAA01064.1.
    D10213 mRNA. Translation: BAA01065.1.
    S71816 mRNA. Translation: AAB31855.1.
    X72307 mRNA. Translation: CAA51054.1. Different initiation.
    AF042856 mRNA. Translation: AAC40051.1.
    X84046 mRNA. Translation: CAA58865.1.
    CH466586 Genomic DNA. Translation: EDL03238.1.
    BC119228 mRNA. Translation: AAI19229.1.
    X81630 Genomic DNA. Translation: CAA57286.1.
    CCDSiCCDS19097.1. [Q08048-1]
    PIRiJC2117. A60185.
    RefSeqiNP_001276387.1. NM_001289458.1. [Q08048-1]
    NP_001276388.1. NM_001289459.1. [Q08048-1]
    NP_001276389.1. NM_001289460.1. [Q08048-3]
    NP_001276390.1. NM_001289461.1. [Q08048-2]
    NP_034557.3. NM_010427.5. [Q08048-1]
    XP_006535691.1. XM_006535628.1. [Q08048-1]
    UniGeneiMm.267078.

    Genome annotation databases

    EnsembliENSMUST00000030683; ENSMUSP00000030683; ENSMUSG00000028864. [Q08048-1]
    GeneIDi15234.
    KEGGimmu:15234.
    UCSCiuc008wne.1. mouse.
    uc008wnf.1. mouse. [Q08048-1]
    uc008wnj.1. mouse. [Q08048-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10212 mRNA. Translation: BAA01064.1 .
    D10213 mRNA. Translation: BAA01065.1 .
    S71816 mRNA. Translation: AAB31855.1 .
    X72307 mRNA. Translation: CAA51054.1 . Different initiation.
    AF042856 mRNA. Translation: AAC40051.1 .
    X84046 mRNA. Translation: CAA58865.1 .
    CH466586 Genomic DNA. Translation: EDL03238.1 .
    BC119228 mRNA. Translation: AAI19229.1 .
    X81630 Genomic DNA. Translation: CAA57286.1 .
    CCDSi CCDS19097.1. [Q08048-1 ]
    PIRi JC2117. A60185.
    RefSeqi NP_001276387.1. NM_001289458.1. [Q08048-1 ]
    NP_001276388.1. NM_001289459.1. [Q08048-1 ]
    NP_001276389.1. NM_001289460.1. [Q08048-3 ]
    NP_001276390.1. NM_001289461.1. [Q08048-2 ]
    NP_034557.3. NM_010427.5. [Q08048-1 ]
    XP_006535691.1. XM_006535628.1. [Q08048-1 ]
    UniGenei Mm.267078.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QJ4 X-ray 2.50 A/B 29-210 [» ]
    3HMR X-ray 2.00 A 31-127 [» ]
    4IUA X-ray 3.05 A/B/C/D/E/F/G/H 31-290 [» ]
    ProteinModelPortali Q08048.
    SMRi Q08048. Positions 37-476, 496-724.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46456N.

    Protein family/group databases

    MEROPSi S01.982.

    PTM databases

    PhosphoSitei Q08048.

    Proteomic databases

    PRIDEi Q08048.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030683 ; ENSMUSP00000030683 ; ENSMUSG00000028864 . [Q08048-1 ]
    GeneIDi 15234.
    KEGGi mmu:15234.
    UCSCi uc008wne.1. mouse.
    uc008wnf.1. mouse. [Q08048-1 ]
    uc008wnj.1. mouse. [Q08048-2 ]

    Organism-specific databases

    CTDi 3082.
    MGIi MGI:96079. Hgf.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00740000115022.
    HOGENOMi HOG000112892.
    HOVERGENi HBG004381.
    InParanoidi Q08048.
    KOi K05460.
    OMAi GSESPWC.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q08048.
    TreeFami TF329901.

    Enzyme and pathway databases

    Reactomei REACT_198701. Interleukin-7 signaling.

    Miscellaneous databases

    EvolutionaryTracei Q08048.
    NextBioi 287831.
    PROi Q08048.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q08048.
    CleanExi MM_HGF.
    Genevestigatori Q08048.

    Family and domain databases

    Gene3Di 2.40.20.10. 4 hits.
    InterProi IPR027284. Hepatocyte_GF.
    IPR024174. HGF_MST1.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR003014. PAN-1_domain.
    IPR003609. Pan_app.
    IPR001254. Peptidase_S1.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00051. Kringle. 4 hits.
    PF00024. PAN_1. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500183. Hepatocyte_GF. 1 hit.
    PIRSF001152. HGF_MST1. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00130. KR. 4 hits.
    SM00473. PAN_AP. 1 hit.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 4 hits.
    PROSITEi PS00021. KRINGLE_1. 4 hits.
    PS50070. KRINGLE_2. 4 hits.
    PS50948. PAN. 1 hit.
    PS50240. TRYPSIN_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of mouse mammary fibroblast-derived mammary growth factor as hepatocyte growth factor."
      Sasaki M., Nishio M., Sasaki T., Enami J.
      Biochem. Biophys. Res. Commun. 199:772-779(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), PROTEIN SEQUENCE OF 496-504.
      Tissue: Mammary fibroblast.
    2. "Structure, genetic mapping, and expression of the mouse Hgf/scatter factor gene."
      Lee C.C., Kozak C.A., Yamada K.M.
      Cell Adhes. Commun. 1:101-111(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factor."
      Liu Y., Michalopoulos G.K., Zarnegar R.
      Biochim. Biophys. Acta 1216:299-303(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    4. "NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo."
      Jakubczak J.L., LaRochelle W.J., Merlino G.
      Mol. Cell. Biol. 18:1275-1283(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM NK1).
      Tissue: Lung.
    5. Sharpe M.J.S., Lane K., Gherardi E.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
      Strain: Swiss.
      Tissue: Fibroblast.
    6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Tissue: Brain.
    8. "Characterisation of the scatter factor/hepatocyte growth factor gene promoter: positive and negative regulatory elements direct gene expression to mesenchymal cells."
      Plaschke-Schluetter A., Behrens J., Gherardi E., Birchmeier W.
      J. Biol. Chem. 270:830-836(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.
      Strain: 129.
    9. "Purified scatter factor stimulates epithelial and vascular endothelial cell migration."
      Rosen E.M., Meromsky L., Setter E., Vinter D.W., Goldberg I.D.
      Proc. Soc. Exp. Biol. Med. 195:34-43(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 184-197; 357-367; 375-383 AND 653-666.
    10. Cited for: PROTEIN SEQUENCE OF 496-519.
    11. "Purification and characterization of biologically active scatter factor from ras-transformed NIH 3T3 conditioned medium."
      Coffer A., Fellows J., Young S., Pappin D., Rahman D.
      Biochem. J. 278:35-41(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 496-519.
    12. "A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist."
      Tolbert W.D., Daugherty J., Gao C., Xie Q., Miranti C., Gherardi E., Woude G.V., Xu H.E.
      Proc. Natl. Acad. Sci. U.S.A. 104:14592-14597(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 29-210, DISULFIDE BONDS.
    13. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 31-127, DISULFIDE BONDS, FUNCTION.

    Entry informationi

    Entry nameiHGF_MOUSE
    AccessioniPrimary (citable) accession number: Q08048
    Secondary accession number(s): O55027
    , Q53WS5, Q61662, Q64007, Q6LBE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3