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Protein

Translocon-associated protein subunit gamma

Gene

Ssr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit gamma
Short name:
TRAP-gamma
Alternative name(s):
Signal sequence receptor subunit gamma
Short name:
SSR-gamma
Gene namesi
Name:Ssr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621630. Ssr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27LumenalSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 54CytoplasmicSequence analysis6
Transmembranei55 – 76HelicalSequence analysisAdd BLAST22
Topological domaini77 – 135LumenalSequence analysisAdd BLAST59
Transmembranei136 – 157HelicalSequence analysisAdd BLAST22
Topological domaini158 – 163CytoplasmicSequence analysis6
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GO_Central
  • Sec61 translocon complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916931 – 185Translocon-associated protein subunit gammaAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ08013.

PTM databases

iPTMnetiQ08013.
PhosphoSitePlusiQ08013.

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

Protein-protein interaction databases

MINTiMINT-4579062.

Structurei

3D structure databases

ProteinModelPortaliQ08013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-gamma family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012424.
InParanoidiQ08013.
KOiK13251.
PhylomeDBiQ08013.

Family and domain databases

InterProiIPR009779. SSR3.
[Graphical view]
PANTHERiPTHR13399. PTHR13399. 1 hit.
PfamiPF07074. TRAP-gamma. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q08013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKGGSKQQ SEEDLLLQDF SRNLSAKSSA LFFGNAFIVS AIPIWLYWRI
60 70 80 90 100
WHMDLIQSAV LYSVMTLVST YLVAFAYKNV KFVLKHKVAQ KREDAVSKEV
110 120 130 140 150
TRKLSEADNR KMSRKEKDER ILWKKNEVAD YEATTFSIFY NNTLFLVLVI
160 170 180
VASFFILKNF NPTVNYILSI SASSGLIALL STGSK
Length:185
Mass (Da):21,064
Last modified:April 26, 2005 - v2
Checksum:i18E0A54483E45D6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163T → R in CAA78405 (PubMed:7916687).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14030 mRNA. Translation: CAA78405.1.
BC062015 mRNA. Translation: AAH62015.1.
PIRiS33294.
RefSeqiNP_112382.2. NM_031120.2.
UniGeneiRn.3264.

Genome annotation databases

GeneIDi81784.
KEGGirno:81784.
UCSCiRGD:621630. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14030 mRNA. Translation: CAA78405.1.
BC062015 mRNA. Translation: AAH62015.1.
PIRiS33294.
RefSeqiNP_112382.2. NM_031120.2.
UniGeneiRn.3264.

3D structure databases

ProteinModelPortaliQ08013.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4579062.

PTM databases

iPTMnetiQ08013.
PhosphoSitePlusiQ08013.

Proteomic databases

PRIDEiQ08013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81784.
KEGGirno:81784.
UCSCiRGD:621630. rat.

Organism-specific databases

CTDi6747.
RGDi621630. Ssr3.

Phylogenomic databases

HOVERGENiHBG012424.
InParanoidiQ08013.
KOiK13251.
PhylomeDBiQ08013.

Miscellaneous databases

PROiQ08013.

Family and domain databases

InterProiIPR009779. SSR3.
[Graphical view]
PANTHERiPTHR13399. PTHR13399. 1 hit.
PfamiPF07074. TRAP-gamma. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSRG_RAT
AccessioniPrimary (citable) accession number: Q08013
Secondary accession number(s): Q6P6U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.