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Q08012

- DRK_DROME

UniProt

Q08012 - DRK_DROME

Protein

Protein enhancer of sevenless 2B

Gene

drk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sevenless binding Source: FlyBase
    3. SH3/SH2 adaptor activity Source: UniProtKB
    4. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. actin filament organization Source: FlyBase
    2. activation of JNKK activity Source: UniProtKB
    3. anterior/posterior axis specification, embryo Source: FlyBase
    4. associative learning Source: FlyBase
    5. embryonic development via the syncytial blastoderm Source: FlyBase
    6. imaginal disc-derived wing morphogenesis Source: FlyBase
    7. negative regulation of epidermal growth factor-activated receptor activity Source: FlyBase
    8. olfactory learning Source: FlyBase
    9. positive regulation of MAPK cascade Source: FlyBase
    10. positive regulation of R7 cell differentiation Source: FlyBase
    11. Ras protein signal transduction Source: FlyBase
    12. regulation of cell shape Source: FlyBase
    13. sevenless signaling pathway Source: FlyBase
    14. short-term memory Source: FlyBase
    15. TORC1 signaling Source: FlyBase
    16. torso signaling pathway Source: FlyBase

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_180238. Spry regulation of FGF signaling.
    REACT_180240. Negative regulation of FGFR signaling.
    REACT_180243. Regulation of signaling by CBL.
    REACT_180781. Signaling by FGFR1 fusion mutants.
    REACT_180783. Signaling by FGFR mutants.
    REACT_180818. SHC-mediated cascade.
    REACT_181315. Regulation of actin dynamics for phagocytic cup formation.
    REACT_181514. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_181975. GAB1 signalosome.
    REACT_182056. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_184384. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_202759. FCERI mediated MAPK activation.
    REACT_203507. SOS-mediated signalling.
    REACT_205557. SHC-mediated signalling.
    REACT_209332. Signalling to RAS.
    REACT_214264. GRB2 events in EGFR signaling.
    REACT_215256. Signal attenuation.
    REACT_217505. FRS2-mediated cascade.
    REACT_226659. PI3K Cascade.
    REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
    SignaLinkiQ08012.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein enhancer of sevenless 2B
    Short name:
    Protein E(sev)2B
    Alternative name(s):
    Downstream of receptor kinase
    SH2-SH3 adapter protein drk
    Gene namesi
    Name:drk
    Synonyms:E(sev)2B
    ORF Names:CG6033
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0004638. drk.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi49 – 491P → L: Inactivates the SH3 domain. Abolishes binding to Dab; when associated with R-199. 1 Publication
    Mutagenesisi67 – 671R → H in Su(sevs11)R1 mutant; ommatidial cell development obstruction. 1 Publication
    Mutagenesisi85 – 851R → K: Disrupts the SH2 domain. Does not affect binding to Dab. 1 Publication
    Mutagenesisi106 – 1061H → Y in E(sev)2B mutant; ommatidial cell development obstruction. 1 Publication
    Mutagenesisi199 – 1991G → R: Disrupts the SH3 domain. Abolishes binding to Dab; when associated with L-49. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Protein enhancer of sevenless 2BPRO_0000088210Add
    BLAST

    Proteomic databases

    PaxDbiQ08012.
    PRIDEiQ08012.

    Expressioni

    Tissue specificityi

    Found mainly in the developing eye and in the antennal disk. Also observed in other imaginal disks tested and in the embryo.

    Gene expression databases

    BgeeiQ08012.

    Interactioni

    Subunit structurei

    Interacts with autophosphorylated sev via SH2 domain and Sos, Dos and Dab via SH3 domains. Binds to tyrosine phosphorylated Dab via the SH2 domain.4 Publications

    Protein-protein interaction databases

    BioGridi62256. 27 interactions.
    DIPiDIP-21223N.
    IntActiQ08012. 4 interactions.
    MINTiMINT-242311.

    Structurei

    Secondary structure

    1
    211
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 53
    Beta strandi13 – 164
    Beta strandi23 – 297
    Turni31 – 333
    Beta strandi36 – 416
    Beta strandi44 – 507
    Beta strandi53 – 553

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2A36NMR-A1-59[»]
    2A37NMR-A1-59[»]
    2AZSNMR-A1-59[»]
    2AZVNMR-A1-59[»]
    ProteinModelPortaliQ08012.
    SMRiQ08012. Positions 1-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ08012.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5858SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 15192SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini152 – 21160SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GRB2/sem-5/DRK family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG298780.
    GeneTreeiENSGT00550000074482.
    InParanoidiQ08012.
    KOiK04364.
    OMAiVETKFVQ.
    OrthoDBiEOG75F4F6.
    PhylomeDBiQ08012.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00017. SH2. 1 hit.
    PF00018. SH3_1. 2 hits.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q08012-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAIAKHDFS ATADDELSFR KTQILKILNM EDDSNWYRAE LDGKEGLIPS    50
    NYIEMKNHDW YYGRITRADA EKLLSNKHEG AFLIRISESS PGDFSLSVKC 100
    PDGVQHFKVL RDAQSKFFLW VVKFNSLNEL VEYHRTASVS RSQDVKLRDM 150
    IPEEMLVQAL YDFVPQESGE LDFRRGDVIT VTDRSDENWW NGEIGNRKGI 200
    FPATYVTPYH S 211
    Length:211
    Mass (Da):24,435
    Last modified:February 1, 1995 - v1
    Checksum:iA1D0614AF358F3C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12446 mRNA. Translation: AAA28898.1.
    L13173 mRNA. No translation available.
    AY135053 Genomic DNA. Translation: AAN17564.1.
    AY135054 Genomic DNA. Translation: AAN17565.1.
    AY135055 Genomic DNA. Translation: AAN17566.1.
    AY135056 Genomic DNA. Translation: AAN17567.1.
    AY135057 Genomic DNA. Translation: AAN17568.1.
    AY135058 Genomic DNA. Translation: AAN17569.1.
    AY135059 Genomic DNA. Translation: AAN17570.1.
    AY135060 Genomic DNA. Translation: AAN17571.1.
    AY135061 Genomic DNA. Translation: AAN17572.1.
    AY135062 Genomic DNA. Translation: AAN17573.1.
    AY135063 Genomic DNA. Translation: AAN17574.1.
    AY135064 Genomic DNA. Translation: AAN17575.1.
    AY135065 Genomic DNA. Translation: AAN17576.1.
    AY135066 Genomic DNA. Translation: AAN17577.1.
    AY135067 Genomic DNA. Translation: AAN17578.1.
    AY135068 Genomic DNA. Translation: AAN17579.1.
    AY135069 Genomic DNA. Translation: AAN17580.1.
    AY135070 Genomic DNA. Translation: AAN17581.1.
    AY135071 Genomic DNA. Translation: AAN17582.1.
    AY135072 Genomic DNA. Translation: AAN17583.1.
    AY135073 Genomic DNA. Translation: AAN17584.1.
    AY135074 Genomic DNA. Translation: AAN17585.1.
    AE013599 Genomic DNA. Translation: AAF58368.1.
    AE013599 Genomic DNA. Translation: AAM68582.1.
    AE013599 Genomic DNA. Translation: AAM68583.1.
    AE013599 Genomic DNA. Translation: AAM68584.1.
    AE013599 Genomic DNA. Translation: AAM68585.1.
    AY061142 mRNA. Translation: AAL28690.1.
    PIRiA46444.
    RefSeqiNP_476858.1. NM_057510.3.
    NP_725302.1. NM_165994.1.
    NP_725303.1. NM_165995.1.
    NP_725304.1. NM_165996.1.
    NP_725305.1. NM_165997.1.
    NP_725306.1. NM_165998.1.
    UniGeneiDm.3707.

    Genome annotation databases

    EnsemblMetazoaiFBtr0087693; FBpp0086812; FBgn0004638.
    FBtr0087694; FBpp0086813; FBgn0004638.
    FBtr0087695; FBpp0086814; FBgn0004638.
    FBtr0087696; FBpp0086815; FBgn0004638.
    FBtr0087697; FBpp0086816; FBgn0004638.
    FBtr0087698; FBpp0086817; FBgn0004638.
    GeneIDi36497.
    KEGGidme:Dmel_CG6033.
    UCSCiCG6033-RC. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12446 mRNA. Translation: AAA28898.1 .
    L13173 mRNA. No translation available.
    AY135053 Genomic DNA. Translation: AAN17564.1 .
    AY135054 Genomic DNA. Translation: AAN17565.1 .
    AY135055 Genomic DNA. Translation: AAN17566.1 .
    AY135056 Genomic DNA. Translation: AAN17567.1 .
    AY135057 Genomic DNA. Translation: AAN17568.1 .
    AY135058 Genomic DNA. Translation: AAN17569.1 .
    AY135059 Genomic DNA. Translation: AAN17570.1 .
    AY135060 Genomic DNA. Translation: AAN17571.1 .
    AY135061 Genomic DNA. Translation: AAN17572.1 .
    AY135062 Genomic DNA. Translation: AAN17573.1 .
    AY135063 Genomic DNA. Translation: AAN17574.1 .
    AY135064 Genomic DNA. Translation: AAN17575.1 .
    AY135065 Genomic DNA. Translation: AAN17576.1 .
    AY135066 Genomic DNA. Translation: AAN17577.1 .
    AY135067 Genomic DNA. Translation: AAN17578.1 .
    AY135068 Genomic DNA. Translation: AAN17579.1 .
    AY135069 Genomic DNA. Translation: AAN17580.1 .
    AY135070 Genomic DNA. Translation: AAN17581.1 .
    AY135071 Genomic DNA. Translation: AAN17582.1 .
    AY135072 Genomic DNA. Translation: AAN17583.1 .
    AY135073 Genomic DNA. Translation: AAN17584.1 .
    AY135074 Genomic DNA. Translation: AAN17585.1 .
    AE013599 Genomic DNA. Translation: AAF58368.1 .
    AE013599 Genomic DNA. Translation: AAM68582.1 .
    AE013599 Genomic DNA. Translation: AAM68583.1 .
    AE013599 Genomic DNA. Translation: AAM68584.1 .
    AE013599 Genomic DNA. Translation: AAM68585.1 .
    AY061142 mRNA. Translation: AAL28690.1 .
    PIRi A46444.
    RefSeqi NP_476858.1. NM_057510.3.
    NP_725302.1. NM_165994.1.
    NP_725303.1. NM_165995.1.
    NP_725304.1. NM_165996.1.
    NP_725305.1. NM_165997.1.
    NP_725306.1. NM_165998.1.
    UniGenei Dm.3707.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2A36 NMR - A 1-59 [» ]
    2A37 NMR - A 1-59 [» ]
    2AZS NMR - A 1-59 [» ]
    2AZV NMR - A 1-59 [» ]
    ProteinModelPortali Q08012.
    SMRi Q08012. Positions 1-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 62256. 27 interactions.
    DIPi DIP-21223N.
    IntActi Q08012. 4 interactions.
    MINTi MINT-242311.

    Proteomic databases

    PaxDbi Q08012.
    PRIDEi Q08012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0087693 ; FBpp0086812 ; FBgn0004638 .
    FBtr0087694 ; FBpp0086813 ; FBgn0004638 .
    FBtr0087695 ; FBpp0086814 ; FBgn0004638 .
    FBtr0087696 ; FBpp0086815 ; FBgn0004638 .
    FBtr0087697 ; FBpp0086816 ; FBgn0004638 .
    FBtr0087698 ; FBpp0086817 ; FBgn0004638 .
    GeneIDi 36497.
    KEGGi dme:Dmel_CG6033.
    UCSCi CG6033-RC. d. melanogaster.

    Organism-specific databases

    CTDi 36497.
    FlyBasei FBgn0004638. drk.

    Phylogenomic databases

    eggNOGi NOG298780.
    GeneTreei ENSGT00550000074482.
    InParanoidi Q08012.
    KOi K04364.
    OMAi VETKFVQ.
    OrthoDBi EOG75F4F6.
    PhylomeDBi Q08012.

    Enzyme and pathway databases

    Reactomei REACT_180238. Spry regulation of FGF signaling.
    REACT_180240. Negative regulation of FGFR signaling.
    REACT_180243. Regulation of signaling by CBL.
    REACT_180781. Signaling by FGFR1 fusion mutants.
    REACT_180783. Signaling by FGFR mutants.
    REACT_180818. SHC-mediated cascade.
    REACT_181315. Regulation of actin dynamics for phagocytic cup formation.
    REACT_181514. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_181975. GAB1 signalosome.
    REACT_182056. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_184384. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_202759. FCERI mediated MAPK activation.
    REACT_203507. SOS-mediated signalling.
    REACT_205557. SHC-mediated signalling.
    REACT_209332. Signalling to RAS.
    REACT_214264. GRB2 events in EGFR signaling.
    REACT_215256. Signal attenuation.
    REACT_217505. FRS2-mediated cascade.
    REACT_226659. PI3K Cascade.
    REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
    SignaLinki Q08012.

    Miscellaneous databases

    ChiTaRSi drk. drosophila.
    EvolutionaryTracei Q08012.
    GenomeRNAii 36497.
    NextBioi 798864.
    PROi Q08012.

    Gene expression databases

    Bgeei Q08012.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00017. SH2. 1 hit.
    PF00018. SH3_1. 2 hits.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50002. SH3. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro."
      Simon M.A., Dodson G.S., Rubin G.M.
      Cell 73:169-177(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SEV AND SOS.
      Tissue: Eye.
    2. "A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos."
      Olivier J.P., Raabe T., Henkemeyer M., Dickson B., Mbamalu G., Margolis B., Schlessinger J., Hafen E., Pawson T.
      Cell 73:179-191(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SEV AND SOS, MUTAGENESIS OF ARG-67 AND HIS-106.
      Tissue: Embryo.
    3. "Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila."
      Riley R.M., Jin W., Gibson G.
      Mol. Ecol. 12:1315-1323(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Ann Arbor1, Ann Arbor16, Ann Arbor18, Ann Arbor20, Ann Arbor3, CA2, CT1, Georgia-5b, Kakamega-2, Kakamega-b1, Kakamega-b2, Kenya-HLa3, Kenya-HLa4, Kenya-HLa6, Kenya-LGC, M2, Makindu-1, Makindu-b1, Makindu-b5, PYR2, Reids2 and Sapporo.
    4. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    5. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    7. "Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase."
      Le N., Simon M.A.
      Mol. Cell. Biol. 18:4844-4854(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAB, MUTAGENESIS OF PRO-49; ARG-85 AND GLY-199.
    8. "SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinases."
      Feller S.M., Wecklein H., Lewitzky M., Kibler E., Raabe T.
      Mech. Dev. 116:129-139(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DOS.

    Entry informationi

    Entry nameiDRK_DROME
    AccessioniPrimary (citable) accession number: Q08012
    Secondary accession number(s): A4UZF9, Q0E989, Q9V6Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3