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Q07ZD2 (NADK_SHEFN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:Sfri_2792
OrganismShewanella frigidimarina (strain NCIMB 400) [Complete proteome] [HAMAP]
Taxonomic identifier318167 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309NAD kinase HAMAP-Rule MF_00361
PRO_1000079513

Regions

Nucleotide binding89 – 902NAD By similarity
Nucleotide binding163 – 1642NAD By similarity
Nucleotide binding204 – 2096NAD By similarity

Sites

Active site891Proton acceptor By similarity
Binding site1741NAD By similarity
Binding site1911NAD By similarity
Binding site1931NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07ZD2 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 1F22C170A585EA32

FASTA30933,870
        10         20         30         40         50         60 
MGINSYVSRP KGITNSNMTK MFQTIGLIGK PHHQGTNLTL TRLHHWLSMQ GFKVIVEGRV 

        70         80         90        100        110        120 
SAELGADVCS MDLLEMGEHC DLAIVVGGDG NMLGAARVLA RFNVAVIGVN RGNLGFLTDL 

       130        140        150        160        170        180 
PPDNFEEALS KVLSGEFETE HRFLLEAEVH RHGKITASNT AVNEAVLHPG KIAHMIQFEV 

       190        200        210        220        230        240 
YIDEQFMYSQ RADGMIVSTP TGSTAYSLSA GGSILTPNLQ ALILVPMFPH TLSCRPIVVD 

       250        260        270        280        290        300 
ACSTIKLVVS PENGENLEVS CDGHVHLAVL PGDEIFIRRS NERLRLIHPK GHNYFHVLRN 


KLGWGSKLF 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000447 Genomic DNA. Translation: ABI72632.1.
RefSeqYP_751471.1. NC_008345.1.

3D structure databases

ProteinModelPortalQ07ZD2.
SMRQ07ZD2. Positions 22-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING318167.Sfri_2792.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI72632; ABI72632; Sfri_2792.
GeneID4279698.
KEGGsfr:Sfri_2792.
PATRIC23499709. VBISheFri14343_2898.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227221.
KOK00858.
OMATHEMLYH.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycSFRI318167:GIXS-2903-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_SHEFN
AccessionPrimary (citable) accession number: Q07ZD2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families