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Q07YY3

- TYSY_SHEFN

UniProt

Q07YY3 - TYSY_SHEFN

Protein

Thymidylate synthase

Gene

thyA

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei160 – 1601UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciSFRI318167:GIXS-3055-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:Sfri_2942
    OrganismiShewanella frigidimarina (strain NCIMB 400)
    Taxonomic identifieri318167 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000000684: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Thymidylate synthasePRO_1000000671Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi318167.Sfri_2942.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07YY3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257900.
    KOiK00560.
    OMAiDVHLYSN.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q07YY3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQYLDLCKR IVDEGEWVNN ARTNKKCLTV INADLVYDVG NNQFPLVTTR    50
    KSFWKSAIAE ILGYLRGYQN AADFRALGTK TWDANANENQ AWLDNPNRKG 100
    PDDMGLIYGA LGRAFPKPDG GHVDLLQQIV DDLSNGIDNR GEILTFYHPG 150
    AFDLGCLRPC MYEHHFSLLG DTLYLNSTQR SCDVPLGLNF NMVQVYVLLA 200
    LMAQITGHKP GKAYHKIVNA HIYEDQLEPM RDVQLAREPF ASPKLIINPK 250
    IKTLKDIETW VTLDDFSVED YQHHDAIKYP FAV 283
    Length:283
    Mass (Da):32,119
    Last modified:October 31, 2006 - v1
    Checksum:iDCB96B1AF7BB8D4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI72781.1.
    RefSeqiYP_751620.1. NC_008345.1.

    Genome annotation databases

    EnsemblBacteriaiABI72781; ABI72781; Sfri_2942.
    GeneIDi4279847.
    KEGGisfr:Sfri_2942.
    PATRICi23500015. VBISheFri14343_3049.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI72781.1 .
    RefSeqi YP_751620.1. NC_008345.1.

    3D structure databases

    ProteinModelPortali Q07YY3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318167.Sfri_2942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI72781 ; ABI72781 ; Sfri_2942 .
    GeneIDi 4279847.
    KEGGi sfr:Sfri_2942.
    PATRICi 23500015. VBISheFri14343_3049.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257900.
    KOi K00560.
    OMAi DVHLYSN.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci SFRI318167:GIXS-3055-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCIMB 400.

    Entry informationi

    Entry nameiTYSY_SHEFN
    AccessioniPrimary (citable) accession number: Q07YY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3