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Q07YJ9 (PDXA_SHEFN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:Sfri_3078
OrganismShewanella frigidimarina (strain NCIMB 400) [Complete proteome] [HAMAP]
Taxonomic identifier318167 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3273274-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_1000128261

Sites

Metal binding1641Divalent metal cation; shared with dimeric partner By similarity
Metal binding2091Divalent metal cation; shared with dimeric partner By similarity
Metal binding2641Divalent metal cation; shared with dimeric partner By similarity
Binding site1341Substrate By similarity
Binding site1351Substrate By similarity
Binding site2721Substrate By similarity
Binding site2811Substrate By similarity
Binding site2901Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07YJ9 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 262E2D02DC9A35B7

FASTA32735,087
        10         20         30         40         50         60 
MTKRIAITPG EPASIGPDLV IKLAQQAWPV ELVVCADPNL LMTRAKMLGL PLQLRPYQPS 

        70         80         90        100        110        120 
QPPKPQTAGT LTIAPFTLAE EVECGVLNEA NSAYVVETLR YAGEKNMSNE FDAVVTGPVH 

       130        140        150        160        170        180 
KGIINQAGIP FSGHTEFFAL QANCADVVMM LAAPGLQVAL MTTHIPLAYV AKAITRDRLH 

       190        200        210        220        230        240 
HIITILHREL VSKFGLGSPK IYVCGLNPHA GEDGHLGREE IDTIIPALNE LREQGMDIVG 

       250        260        270        280        290        300 
PLPADTLFQP KYLEQADVVL AMYHDQGLPV LKSLGFGKSV NITLGLPYIR TSVDHGTALE 

       310        320 
LAGSGKADCG SFTCALNKAI ELASKSK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000447 Genomic DNA. Translation: ABI72915.1.
RefSeqYP_751754.1. NC_008345.1.

3D structure databases

ProteinModelPortalQ07YJ9.
SMRQ07YJ9. Positions 2-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING318167.Sfri_3078.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI72915; ABI72915; Sfri_3078.
GeneID4279981.
KEGGsfr:Sfri_3078.
PATRIC23500301. VBISheFri14343_3191.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221592.
KOK00097.
OMAYVWDTPL.
OrthoDBEOG6GN6ZC.
ProtClustDBPRK00232.

Enzyme and pathway databases

BioCycSFRI318167:GIXS-3192-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_SHEFN
AccessionPrimary (citable) accession number: Q07YJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 31, 2006
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways