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Q07YC9 (GCSP_SHEFN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Sfri_3149
OrganismShewanella frigidimarina (strain NCIMB 400) [Complete proteome] [HAMAP]
Taxonomic identifier318167 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045609

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07YC9 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 1CCDF7FAC46FE711

FASTA962104,802
        10         20         30         40         50         60 
MTKQTLTQLE QHELFLTRHI GPNAEQQQEM LNFIGAESLE DLTAQTVPGK IRLPQDLTIG 

        70         80         90        100        110        120 
DSCGEAEGIA YIRNIADKNK VFKSYIGMGY YGVQVPNVIL RNVFENPGWY TAYTPYQPEI 

       130        140        150        160        170        180 
AQGRLEAILN FQQVSMDLTG LDLASASLLD EATAAAEAMA LAKRVSKAKK ANIFFVADDV 

       190        200        210        220        230        240 
FPQTLDVVKT RAECFGFEVV VGPASEAVNY ELFGALFQYT NRIGQITDYT ELFATLRDNK 

       250        260        270        280        290        300 
VIVTVAADIM SLMLLKSPGA MGADVVFGSA QRFGVPMGYG GPHAAFFVAR DEHKRSMPGR 

       310        320        330        340        350        360 
IIGVSKDTRG NSALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV FHGPQGLKTI 

       370        380        390        400        410        420 
ASRINRLADI LAAGLTAKGL TLANTTWFDT ISVKGADVAA INARAIAAQV NLRIDADGVF 

       430        440        450        460        470        480 
GISLDETTIR TDIADLFDVI LGAGHGLDVA TFDADIVANG SQSIPDALVR QDAVLTHPTF 

       490        500        510        520        530        540 
NRYQSETEMM RYIKRLENKD LALNHSMISL GSCTMKLNAA VEMLPVSWPE FANMHPFCPL 

       550        560        570        580        590        600 
DQAQGYTQLI NELSEFLVKI TGYDSVCIQP NSGAQGEYAG LLAIKKYHES RGDAHRNICL 

       610        620        630        640        650        660 
IPQSAHGTNP ASAQLAGMKV VVTACDKQGN VDLEDLRTKA AELADSLSCI MITYPSTHGV 

       670        680        690        700        710        720 
YEESIREVCE IVHQYGGQVY LDGANMNAQV GLTSPGFIGA DVSHLNLHKT FAIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVKSH LAPFVAGHTV IKPGRESDHN GAVSAAPYGS ASILPISWMY IKLLGTKGVK 

       790        800        810        820        830        840 
QSTQTALLNA NYIMKKLSAH YPVLFTGRND RVAHECIIDL RPLKETSGVT EMDIAKRLND 

       850        860        870        880        890        900 
YGFHSPTMSF PVAGTLMIEP TESESKVELD RFIEAMISIR GEITKVEAGE WPVDNNPLHN 

       910        920        930        940        950        960 
APHTLADIMD PEFDSRPYSR EVAVFPTAAV KANKFWPTVN RIDDVYGDRN LMCSCVPLSD 


YE 

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References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000447 Genomic DNA. Translation: ABI72985.1.
RefSeqYP_751824.1. NC_008345.1.

3D structure databases

ProteinModelPortalQ07YC9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING318167.Sfri_3149.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI72985; ABI72985; Sfri_3149.
GeneID4280051.
KEGGsfr:Sfri_3149.
PATRIC23500445. VBISheFri14343_3263.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycSFRI318167:GIXS-3263-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SHEFN
AccessionPrimary (citable) accession number: Q07YC9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families