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Q07YC9

- GCSP_SHEFN

UniProt

Q07YC9 - GCSP_SHEFN

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Sfri_3149
Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSFRI318167:GIXS-3263-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Sfri_3149
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000684: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi318167.Sfri_3149.

Structurei

3D structure databases

ProteinModelPortaliQ07YC9.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07YC9-1 [UniParc]FASTAAdd to Basket

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MTKQTLTQLE QHELFLTRHI GPNAEQQQEM LNFIGAESLE DLTAQTVPGK    50
IRLPQDLTIG DSCGEAEGIA YIRNIADKNK VFKSYIGMGY YGVQVPNVIL 100
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVVKT RAECFGFEVV 200
VGPASEAVNY ELFGALFQYT NRIGQITDYT ELFATLRDNK VIVTVAADIM 250
SLMLLKSPGA MGADVVFGSA QRFGVPMGYG GPHAAFFVAR DEHKRSMPGR 300
IIGVSKDTRG NSALRMAMQT REQHIRREKA NSNICTAQIL LANMASFYAV 350
FHGPQGLKTI ASRINRLADI LAAGLTAKGL TLANTTWFDT ISVKGADVAA 400
INARAIAAQV NLRIDADGVF GISLDETTIR TDIADLFDVI LGAGHGLDVA 450
TFDADIVANG SQSIPDALVR QDAVLTHPTF NRYQSETEMM RYIKRLENKD 500
LALNHSMISL GSCTMKLNAA VEMLPVSWPE FANMHPFCPL DQAQGYTQLI 550
NELSEFLVKI TGYDSVCIQP NSGAQGEYAG LLAIKKYHES RGDAHRNICL 600
IPQSAHGTNP ASAQLAGMKV VVTACDKQGN VDLEDLRTKA AELADSLSCI 650
MITYPSTHGV YEESIREVCE IVHQYGGQVY LDGANMNAQV GLTSPGFIGA 700
DVSHLNLHKT FAIPHGGGGP GMGPIGVKSH LAPFVAGHTV IKPGRESDHN 750
GAVSAAPYGS ASILPISWMY IKLLGTKGVK QSTQTALLNA NYIMKKLSAH 800
YPVLFTGRND RVAHECIIDL RPLKETSGVT EMDIAKRLND YGFHSPTMSF 850
PVAGTLMIEP TESESKVELD RFIEAMISIR GEITKVEAGE WPVDNNPLHN 900
APHTLADIMD PEFDSRPYSR EVAVFPTAAV KANKFWPTVN RIDDVYGDRN 950
LMCSCVPLSD YE 962
Length:962
Mass (Da):104,802
Last modified:October 31, 2006 - v1
Checksum:i1CCDF7FAC46FE711
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000447 Genomic DNA. Translation: ABI72985.1.
RefSeqiWP_011638588.1. NC_008345.1.
YP_751824.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI72985; ABI72985; Sfri_3149.
GeneIDi4280051.
KEGGisfr:Sfri_3149.
PATRICi23500445. VBISheFri14343_3263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000447 Genomic DNA. Translation: ABI72985.1 .
RefSeqi WP_011638588.1. NC_008345.1.
YP_751824.1. NC_008345.1.

3D structure databases

ProteinModelPortali Q07YC9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 318167.Sfri_3149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI72985 ; ABI72985 ; Sfri_3149 .
GeneIDi 4280051.
KEGGi sfr:Sfri_3149.
PATRICi 23500445. VBISheFri14343_3263.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SFRI318167:GIXS-3263-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIMB 400.

Entry informationi

Entry nameiGCSP_SHEFN
AccessioniPrimary (citable) accession number: Q07YC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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