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Q07Y78

- HLDE_SHEFN

UniProt

Q07Y78 - HLDE_SHEFN

Protein

Bifunctional protein HldE

Gene

hldE

Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.UniRule annotation
    Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.UniRule annotation

    Catalytic activityi

    D-glycero-beta-D-manno-heptose 7-phosphate + ATP = D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP.UniRule annotation
    D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei264 – 2641UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 1984ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. heptose-1-phosphate adenylyltransferase activity Source: UniProtKB-HAMAP
    3. heptose 7-phosphate kinase activity Source: UniProtKB-HAMAP
    4. phosphotransferase activity, alcohol group as acceptor Source: InterPro

    GO - Biological processi

    1. ADP-L-glycero-beta-D-manno-heptose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFRI318167:GIXS-3314-MONOMER.
    UniPathwayiUPA00356; UER00437.
    UPA00356; UER00439.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein HldEUniRule annotation
    Including the following 2 domains:
    D-beta-D-heptose 7-phosphate kinaseUniRule annotation (EC:2.7.1.167UniRule annotation)
    Alternative name(s):
    D-beta-D-heptose 7-phosphotransferaseUniRule annotation
    D-glycero-beta-D-manno-heptose-7-phosphate kinaseUniRule annotation
    D-beta-D-heptose 1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.70UniRule annotation)
    Alternative name(s):
    D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferaseUniRule annotation
    Gene namesi
    Name:hldEUniRule annotation
    Ordered Locus Names:Sfri_3200
    OrganismiShewanella frigidimarina (strain NCIMB 400)
    Taxonomic identifieri318167 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000000684: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Bifunctional protein HldEPRO_0000291688Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi318167.Sfri_3200.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07Y78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 319319RibokinaseAdd
    BLAST
    Regioni345 – 476132CytidylyltransferaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the carbohydrate kinase PfkB family.UniRule annotation
    In the C-terminal section; belongs to the cytidylyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2870.
    HOGENOMiHOG000237584.
    KOiK03272.
    OMAiTKLRVMS.
    OrthoDBiEOG68Q0W4.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_01603. HldE.
    InterProiIPR023030. Bifunc_HldE.
    IPR002173. Carboh/pur_kinase_PfkB_CS.
    IPR004821. Cyt_trans-like.
    IPR011611. PfkB_dom.
    IPR011913. RfaE_dom_I.
    IPR011914. RfaE_dom_II.
    IPR029056. Ribokinase-like.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01467. CTP_transf_2. 1 hit.
    PF00294. PfkB. 1 hit.
    [Graphical view]
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR02198. rfaE_dom_I. 1 hit.
    TIGR02199. rfaE_dom_II. 1 hit.
    PROSITEiPS00583. PFKB_KINASES_1. 1 hit.
    PS00584. PFKB_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q07Y78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVSLPAFEN ARVLVIGDVM LDRYWVGPTG RISPEAPVPV VKINQIEDRP    50
    GGAANVALNI ATLGGHVQLA GIVGQDETAQ ALTQGVKVFG VEPQWLTVAD 100
    KPTITKLRVL SRNQQLIRLD FEEQFDKATS QALFAQSEAI LDNVDVLVLS 150
    DYAKGAIDEP KDFIAKARAK GVKVLVDPKG HDFARYHGAS LITPNMSEFE 200
    AVVGTVTSED DLIEKAQKLI KLHDFEAILV TRSEKGMTLV SQNQPELHIP 250
    TVAREVHDVT GAGDTVISAL ATSIAAGASL AQACAIANTA AGVVVGKLGT 300
    STVSRIELIQ ALALNHGESG FGVMTEDQLA YAMDQARLRG ERIVMTNGCF 350
    DILHAGHVSY LQQAKALGDR LIVAVNDDSS VTRLKGPGRP VNPVDRRMAV 400
    LAGLASVDWV VPFTEDTPQR IITRLLPDSL VKGGDYKVED IAGGAEVIAA 450
    GGKVEVLGFE DGVSTTAIIQ NIMSQK 476
    Length:476
    Mass (Da):50,701
    Last modified:October 31, 2006 - v1
    Checksum:iCFDA4E7393AA3515
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI73036.1.
    RefSeqiWP_011638639.1. NC_008345.1.
    YP_751875.1. NC_008345.1.

    Genome annotation databases

    EnsemblBacteriaiABI73036; ABI73036; Sfri_3200.
    GeneIDi4280102.
    KEGGisfr:Sfri_3200.
    PATRICi23500551. VBISheFri14343_3316.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000447 Genomic DNA. Translation: ABI73036.1 .
    RefSeqi WP_011638639.1. NC_008345.1.
    YP_751875.1. NC_008345.1.

    3D structure databases

    ProteinModelPortali Q07Y78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 318167.Sfri_3200.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABI73036 ; ABI73036 ; Sfri_3200 .
    GeneIDi 4280102.
    KEGGi sfr:Sfri_3200.
    PATRICi 23500551. VBISheFri14343_3316.

    Phylogenomic databases

    eggNOGi COG2870.
    HOGENOMi HOG000237584.
    KOi K03272.
    OMAi TKLRVMS.
    OrthoDBi EOG68Q0W4.

    Enzyme and pathway databases

    UniPathwayi UPA00356 ; UER00437 .
    UPA00356 ; UER00439 .
    BioCyci SFRI318167:GIXS-3314-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_01603. HldE.
    InterProi IPR023030. Bifunc_HldE.
    IPR002173. Carboh/pur_kinase_PfkB_CS.
    IPR004821. Cyt_trans-like.
    IPR011611. PfkB_dom.
    IPR011913. RfaE_dom_I.
    IPR011914. RfaE_dom_II.
    IPR029056. Ribokinase-like.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01467. CTP_transf_2. 1 hit.
    PF00294. PfkB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR02198. rfaE_dom_I. 1 hit.
    TIGR02199. rfaE_dom_II. 1 hit.
    PROSITEi PS00583. PFKB_KINASES_1. 1 hit.
    PS00584. PFKB_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCIMB 400.

    Entry informationi

    Entry nameiHLDE_SHEFN
    AccessioniPrimary (citable) accession number: Q07Y78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3