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Q07Y78

- HLDE_SHEFN

UniProt

Q07Y78 - HLDE_SHEFN

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Protein
Bifunctional protein HldE
Gene
hldE, Sfri_3200
Organism
Shewanella frigidimarina (strain NCIMB 400)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate By similarity.UniRule annotation
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose By similarity.UniRule annotation

Catalytic activityi

D-glycero-beta-D-manno-heptose 7-phosphate + ATP = D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP.UniRule annotation
D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei264 – 2641 Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 1984ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. heptose 7-phosphate kinase activity Source: UniProtKB-HAMAP
  3. heptose-1-phosphate adenylyltransferase activity Source: UniProtKB-HAMAP
  4. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. ADP-L-glycero-beta-D-manno-heptose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFRI318167:GIXS-3314-MONOMER.
UniPathwayiUPA00356; UER00437.
UPA00356; UER00439.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein HldE
Including the following 2 domains:
D-beta-D-heptose 7-phosphate kinase (EC:2.7.1.167)
Alternative name(s):
D-beta-D-heptose 7-phosphotransferase
D-glycero-beta-D-manno-heptose-7-phosphate kinase
D-beta-D-heptose 1-phosphate adenylyltransferase (EC:2.7.7.70)
Alternative name(s):
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
Gene namesi
Name:hldE
Ordered Locus Names:Sfri_3200
OrganismiShewanella frigidimarina (strain NCIMB 400)
Taxonomic identifieri318167 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000684: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Bifunctional protein HldEUniRule annotation
PRO_0000291688Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi318167.Sfri_3200.

Structurei

3D structure databases

ProteinModelPortaliQ07Y78.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 319319RibokinaseUniRule annotation
Add
BLAST
Regioni345 – 476132CytidylyltransferaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
In the C-terminal section; belongs to the cytidylyltransferase family.

Phylogenomic databases

eggNOGiCOG2870.
HOGENOMiHOG000237584.
KOiK03272.
OMAiTKLRVMS.
OrthoDBiEOG68Q0W4.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_01603. HldE.
InterProiIPR023030. Bifunc_HldE.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR004821. Cyt_trans-like.
IPR011611. PfkB_dom.
IPR011913. RfaE_dom_I.
IPR011914. RfaE_dom_II.
IPR029056. Ribokinase-like.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_2. 1 hit.
PF00294. PfkB. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR02198. rfaE_dom_I. 1 hit.
TIGR02199. rfaE_dom_II. 1 hit.
PROSITEiPS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07Y78-1 [UniParc]FASTAAdd to Basket

« Hide

MKVSLPAFEN ARVLVIGDVM LDRYWVGPTG RISPEAPVPV VKINQIEDRP    50
GGAANVALNI ATLGGHVQLA GIVGQDETAQ ALTQGVKVFG VEPQWLTVAD 100
KPTITKLRVL SRNQQLIRLD FEEQFDKATS QALFAQSEAI LDNVDVLVLS 150
DYAKGAIDEP KDFIAKARAK GVKVLVDPKG HDFARYHGAS LITPNMSEFE 200
AVVGTVTSED DLIEKAQKLI KLHDFEAILV TRSEKGMTLV SQNQPELHIP 250
TVAREVHDVT GAGDTVISAL ATSIAAGASL AQACAIANTA AGVVVGKLGT 300
STVSRIELIQ ALALNHGESG FGVMTEDQLA YAMDQARLRG ERIVMTNGCF 350
DILHAGHVSY LQQAKALGDR LIVAVNDDSS VTRLKGPGRP VNPVDRRMAV 400
LAGLASVDWV VPFTEDTPQR IITRLLPDSL VKGGDYKVED IAGGAEVIAA 450
GGKVEVLGFE DGVSTTAIIQ NIMSQK 476
Length:476
Mass (Da):50,701
Last modified:October 31, 2006 - v1
Checksum:iCFDA4E7393AA3515
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000447 Genomic DNA. Translation: ABI73036.1.
RefSeqiWP_011638639.1. NC_008345.1.
YP_751875.1. NC_008345.1.

Genome annotation databases

EnsemblBacteriaiABI73036; ABI73036; Sfri_3200.
GeneIDi4280102.
KEGGisfr:Sfri_3200.
PATRICi23500551. VBISheFri14343_3316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000447 Genomic DNA. Translation: ABI73036.1 .
RefSeqi WP_011638639.1. NC_008345.1.
YP_751875.1. NC_008345.1.

3D structure databases

ProteinModelPortali Q07Y78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 318167.Sfri_3200.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI73036 ; ABI73036 ; Sfri_3200 .
GeneIDi 4280102.
KEGGi sfr:Sfri_3200.
PATRICi 23500551. VBISheFri14343_3316.

Phylogenomic databases

eggNOGi COG2870.
HOGENOMi HOG000237584.
KOi K03272.
OMAi TKLRVMS.
OrthoDBi EOG68Q0W4.

Enzyme and pathway databases

UniPathwayi UPA00356 ; UER00437 .
UPA00356 ; UER00439 .
BioCyci SFRI318167:GIXS-3314-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_01603. HldE.
InterProi IPR023030. Bifunc_HldE.
IPR002173. Carboh/pur_kinase_PfkB_CS.
IPR004821. Cyt_trans-like.
IPR011611. PfkB_dom.
IPR011913. RfaE_dom_I.
IPR011914. RfaE_dom_II.
IPR029056. Ribokinase-like.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01467. CTP_transf_2. 1 hit.
PF00294. PfkB. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR02198. rfaE_dom_I. 1 hit.
TIGR02199. rfaE_dom_II. 1 hit.
PROSITEi PS00583. PFKB_KINASES_1. 1 hit.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCIMB 400.

Entry informationi

Entry nameiHLDE_SHEFN
AccessioniPrimary (citable) accession number: Q07Y78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 31, 2006
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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