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Reviewed, UniProtKB/Swiss-Prot Q07W60 (HLDD_SHEFN)

Last modified June 16, 2009. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADP-L-glycero-D-manno-heptose-6-epimerase
    EC=5.1.3.20
Alternative name(s):
    ADP-L-glycero-beta-D-manno-heptose-6-epimerase
      Short name=ADP-glyceromanno-heptose 6-epimerase
      Short name=ADP-hep 6-epimerase
      Short name=AGME
Gene names
Name: hldD
Ordered Locus Names: Sfri_3929
OrganismShewanella frigidimarina (strain NCIMB 400) [Complete proteome] [HAMAP]
Taxonomic identifier318167 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

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Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose By similarity.

Catalytic activity

ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. HAMAP MF_01601

Cofactor

Binds 1 NADP+ per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 4/4. HAMAP MF_01601

Subunit structure

Homopentamer By similarity.

Domain

Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain By similarity.

Sequence similarities

Belongs to the sugar epimerase family. HldD subfamily.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
   LigandNADP
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbohydrate metabolic process

Inferred from electronic annotation. Source: HAMAP

cellular metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionADP-glyceromanno-heptose 6-epimerase activity

Inferred from electronic annotation. Source: HAMAP

NADP or NADPH binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317ADP-L-glycero-D-manno-heptose-6-epimerase HAMAP MF_01601
PRO_1000069367

Regions

Nucleotide binding10 – 112NADP By similarity
Nucleotide binding31 – 322NADP By similarity
Nucleotide binding75 – 795NADP By similarity
Region198 – 2014Substrate binding By similarity

Sites

Active site1391Proton acceptor By similarity
Active site1751Proton acceptor By similarity
Binding site381NADP By similarity
Binding site531NADP By similarity
Binding site921NADP By similarity
Binding site1431NADP By similarity
Binding site1661Substrate By similarity
Binding site1671NADP; via amide nitrogen By similarity
Binding site1751NADP By similarity
Binding site1771Substrate; via carbonyl oxygen By similarity
Binding site1841Substrate By similarity
Binding site2111Substrate By similarity
Binding site2751Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q07W60-1 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 43BB16220B4E2652

FASTA31735,735
        10         20         30         40         50         60 
MIVVTGAAGF IGSNLVKQLN AMGRNDIIAV DDLTDGTQMF NLADCEIADY LDKDDFIKQI 

        70         80         90        100        110        120 
KAGDFDNKLE VIFHQGACSS TTEWDGKFMM ANNFEYSKTL LHYSQANNCQ FIYASSASVY 

       130        140        150        160        170        180 
GGSEKFIEQR ELEKPLNVYA YSKFLFDQYV RQQKLTGQVA GLRYFNVYGP REQHKGGMAS 

       190        200        210        220        230        240 
VAFHFNNQIN TNGVCRLFEG VDGYENGQQL RDFVFVEDVV KVNLWLWQNP SVSGIYNCGT 

       250        260        270        280        290        300 
GQAQSFNDVA NAVIAYHGKG HIEYIPFPDK LKGAYQSYTQ ADLTQLRAAG YQGEFKTVEQ 

       310 
AVPEYLDWLK TQHFIGQ

« Hide

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References

[1]"Complete sequence of Shewanella frigidimarina NCIMB 400."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Fredrickson J.K., Kolker E., McCuel L.A., DiChristina T., Nealson K.H., Newman D., Tiedje J.M. expand/collapse author list , Zhou J., Romine M.F., Culley D.E., Serres M., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000447 Genomic DNA. Translation: ABI73754.1.
RefSeqYP_752593.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4280820.
GenomeReviewsGene locus Sfri_3929 in contig CP000447_GR.
KEGGsfr:Sfri_3929.
NMPDRfig|318167.10.peg.3747.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ07W60.
OMAQ07W60. FGPNEYH.

Family and domain databases

HAMAPMF_01601.
[Tree]
InterProIPR001509. Epimerase_deHydtase.
IPR011912. Heptose_epim.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR10366:SF29. Heptose_epim. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR02197. heptose_epim. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameHLDD_SHEFN
AccessionPrimary (citable) accession number: Q07W60
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 31, 2006
Last modified: June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents