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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79S-adenosyl-L-methionineUniRule annotation1
Binding sitei104S-adenosyl-L-methionineUniRule annotation1
Binding sitei131S-adenosyl-L-methionineUniRule annotation1
Active sitei153By similarity1
Binding sitei153S-adenosyl-L-methionineUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRPAL316055:G1G7C-202-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:RPE_0200
OrganismiRhodopseudomonas palustris (strain BisA53)
Taxonomic identifieri316055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000000654 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002882131 – 250tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST250

Interactioni

Protein-protein interaction databases

STRINGi316055.RPE_0200.

Structurei

3D structure databases

ProteinModelPortaliQ07V74.
SMRiQ07V74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1. Bacteria.
COG0220. LUCA.
HOGENOMiHOG000073969.
KOiK03439.
OMAiPDPWHKS.
OrthoDBiPOG091H015P.

Family and domain databases

HAMAPiMF_01057. tRNA_methyltr_TrmB. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR003358. tRNA_(Gua-N-7)_MeTrfase_Trmb.
PANTHERiPTHR23417. PTHR23417. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiView protein in PROSITE
PS51625. SAM_MT_TRMB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07V74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPDDPRDAS DASLADATAD SASRGHGSFF GRRKGHKLRA HQAELIADLL
60 70 80 90 100
PQLSFDLAAP PPADLRALFE PGVDQVKLEI GFGGGEHLVA EAEAHPATGF
110 120 130 140 150
IGCEPYVNGM AKILAQIEAR GIRNIRLFAG DAAELLAWAP KASLARIDLI
160 170 180 190 200
HPDPWPKRRH WKRRFVQDAT VTAMARALRD DGEFRFVCDI DDYSAWTLSH
210 220 230 240 250
LTRSPDFAWT AERARDWQNP FAGYTMTRYG RKAEREGRRA AYLHFQRNAA
Length:250
Mass (Da):27,846
Last modified:October 31, 2006 - v1
Checksum:iD21C4991F89731EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000463 Genomic DNA. Translation: ABJ04160.1.
RefSeqiWP_011661654.1. NC_008435.1.

Genome annotation databases

EnsemblBacteriaiABJ04160; ABJ04160; RPE_0200.
KEGGirpe:RPE_0200.

Similar proteinsi

Entry informationi

Entry nameiTRMB_RHOP5
AccessioniPrimary (citable) accession number: Q07V74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 31, 2006
Last modified: February 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome