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Protein

Catalase-peroxidase

Gene

katG

Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei93 – 931Transition state stabilizerUniRule annotation
Active sitei97 – 971Proton acceptorUniRule annotation
Metal bindingi259 – 2591Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRPAL316055:GHR9-256-MONOMER.

Protein family/group databases

PeroxiBasei3574. RpCP01_BisA53.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:RPE_0253
OrganismiRhodopseudomonas palustris (strain BisA53)
Taxonomic identifieri316055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000000654 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121UniRule annotationAdd
BLAST
Chaini22 – 730709Catalase-peroxidasePRO_0000354893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki96 ↔ 218Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-244)UniRule annotation
Cross-linki218 ↔ 244Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi316055.RPE_0253.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07V22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAKTDDKDA GKCPFSSGSH AHRNRDWWPD QLDIQVLHHN SKKSDPLGEA
60 70 80 90 100
FNYAEEFKKL DLAALKQDLT ALMTDSQDWW PADFGHYGGL FIRLAWHSAG
110 120 130 140 150
TYRISDGRGG AGAGQQRFAP LNSWPDNANL DKARRLLWPI KQKYGNKISW
160 170 180 190 200
ADLFVLSGNV ALESMGFKTF GFAGGRADTW EPEELYWGPE GTWLGDSRYS
210 220 230 240 250
GERELSDPLG AVQMGLIYVN PEGPNGNPDP VGSAKDIRET FYRMAMNDEE
260 270 280 290 300
TVALIAGGHT FGKTHGAGDP SLLGPDPEAG ALEDQGLGWK SGYGTGFGAD
310 320 330 340 350
AITGGPEVIW SQEPTKWSNH FFENLFNFDY ELTKSPAGAQ QWVAKNAEPS
360 370 380 390 400
IPDPFDPSKK RLPTMLTSDL ALRFDPIYEK ISRRFFENPD QFADAFARAW
410 420 430 440 450
YKLTHRDMGP VPRYLGPEVP KEVLLWQDPV PAVDHELVSE QDIAALKAKI
460 470 480 490 500
LASGLSVAQL VSAAWASAST FRGSDKRGGA NGGRIRLSPQ KDWEVNHPAE
510 520 530 540 550
LAQVLSKLEA IQSEFNAQGG GKKVSIADLI VLGGAAAIEK AAQEAGTAVT
560 570 580 590 600
VPFTPGRTDA SQEQTDVESF KPLEPRADGF RNYVSSIRHQ FMKPEEALVD
610 620 630 640 650
KAQLLKLTGP ELTVLVGGLR VLGANYGHTT HGVLTDRPER LSNDFFVNLL
660 670 680 690 700
DMKYAWAPSP TTTGIYEARD RKSGELKWTG TRVDLIFGSH SQLRAFAEVY
710 720 730
AQADAKEKFV HDFVAAWTKV MNADRFDIVR
Length:730
Mass (Da):80,435
Last modified:October 31, 2006 - v1
Checksum:i24396EA3EA993356
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000463 Genomic DNA. Translation: ABJ04212.1.
RefSeqiWP_011661706.1. NC_008435.1.

Genome annotation databases

EnsemblBacteriaiABJ04212; ABJ04212; RPE_0253.
KEGGirpe:RPE_0253.
PATRICi23254980. VBIRhoPal93214_0256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000463 Genomic DNA. Translation: ABJ04212.1.
RefSeqiWP_011661706.1. NC_008435.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316055.RPE_0253.

Protein family/group databases

PeroxiBasei3574. RpCP01_BisA53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ04212; ABJ04212; RPE_0253.
KEGGirpe:RPE_0253.
PATRICi23254980. VBIRhoPal93214_0256.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciRPAL316055:GHR9-256-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_RHOP5
AccessioniPrimary (citable) accession number: Q07V22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.