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Q07UX5

- MDH_RHOP5

UniProt

Q07UX5 - MDH_RHOP5

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADUniRule annotation
Binding sitei83 – 831SubstrateUniRule annotation
Binding sitei89 – 891SubstrateUniRule annotation
Binding sitei96 – 961NADUniRule annotation
Binding sitei121 – 1211SubstrateUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei176 – 1761Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADUniRule annotation
Nucleotide bindingi119 – 1213NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRPAL316055:GHR9-303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:RPE_0300
OrganismiRhodopseudomonas palustris (strain BisA53)
Taxonomic identifieri316055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000000654: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Malate dehydrogenasePRO_1000026484Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316055.RPE_0300.

Structurei

3D structure databases

ProteinModelPortaliQ07UX5.
SMRiQ07UX5. Positions 1-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07UX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARDKIALIG SGQIGGTLAH LVGLKELGDV VMFDIAEGIP QGKALDIAQS
60 70 80 90 100
SPVDGFDAKF TGANSYEALD GASVCIVTAG VPRKPGMSRD DLLSINLKVM
110 120 130 140 150
EQVGAGIKKY APNAFVICIT NPLDAMVWAL QKACGLPHNK VVGMAGVLDS
160 170 180 190 200
ARFRYFLADE FNVSVEDVTA FVLGGHGDTM VPLVKYSTVA GIPLPDLVKM
210 220 230 240 250
GWTSQARLDE IVDRTRNGGA EIVNLLKTGS AFYAPATSAI AMAESYLRDK
260 270 280 290 300
KRVVPVAAYL NGEYGVKDMY VGVPVVIGAK GVERIVEIEL AGKDREAFDK
310 320
SVGAVQGLVE ACKKIAPELL GA
Length:322
Mass (Da):33,972
Last modified:October 31, 2006 - v1
Checksum:i7A6AA8D477A5BB12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000463 Genomic DNA. Translation: ABJ04259.1.
RefSeqiYP_779239.1. NC_008435.1.

Genome annotation databases

EnsemblBacteriaiABJ04259; ABJ04259; RPE_0300.
GeneIDi4359601.
KEGGirpe:RPE_0300.
PATRICi23255072. VBIRhoPal93214_0302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000463 Genomic DNA. Translation: ABJ04259.1 .
RefSeqi YP_779239.1. NC_008435.1.

3D structure databases

ProteinModelPortali Q07UX5.
SMRi Q07UX5. Positions 1-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316055.RPE_0300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ04259 ; ABJ04259 ; RPE_0300 .
GeneIDi 4359601.
KEGGi rpe:RPE_0300.
PATRICi 23255072. VBIRhoPal93214_0302.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci RPAL316055:GHR9-303-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisA53.

Entry informationi

Entry nameiMDH_RHOP5
AccessioniPrimary (citable) accession number: Q07UX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3