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Q07UN5 (SYL_RHOP5) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:RPE_0390
OrganismRhodopseudomonas palustris (strain BisA53) [Complete proteome] [HAMAP]
Taxonomic identifier316055 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas

Protein attributes

Sequence length888 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 888888Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009410

Regions

Motif43 – 5311"HIGH" region HAMAP-Rule MF_00049
Motif644 – 6485"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6471ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07UN5 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: FFE5EA905AB360C3

FASTA88899,417
        10         20         30         40         50         60 
MTSERYNARE SEPKWQRRWD DDKIFATQND DPRPKYYVLE MFPYPSGRIH MGHVRNYTMG 

        70         80         90        100        110        120 
DVVARTMRAR GFNVLHPMGW DAFGLPAENA AIERKVAPKA WTYDNIAAMK KQLQTMGLSL 

       130        140        150        160        170        180 
DWAREFATCD PSYYKHQQKM FLDFLKAGLA EREKRKINWD PVDMTVLANE QVIDGRGWRS 

       190        200        210        220        230        240 
GAVVEQREMN QWVFKITRYS QDLLDALDRL DRWPDKVRLM QRNWIGRSEG MLVRFALDAA 

       250        260        270        280        290        300 
TTPAGESELK IFTTRADTLF GAKFMAIAAD HPLALAAAPK NPKIKDFIDE CKKRGTAQAD 

       310        320        330        340        350        360 
IDTAEKQGID TGIRAVHPFD PEWKLPVYVA NFVLMEYGTG AIFGCPAHDQ RDLDFVNKYD 

       370        380        390        400        410        420 
LGNTPVVCPE GQDPASFVIT DVAYDGDGRL INSRFLDGLS IDQAKEEVAK RLETATRDGA 

       430        440        450        460        470        480 
PIGERKVNFR LRDWGISRQR YWGCPIPVIH CPKCDVVPVP DADLPVVLPE DVSFDKPGNA 

       490        500        510        520        530        540 
LDHHPTWKHV TCPKCGGKAV RETDTMDTFV DSSWYFARFT DPWNENAPTT PDVVNKMMPV 

       550        560        570        580        590        600 
DQYIGGVEHA ILHLLYSRFF TRAMKATGHV GLDEPFAGMF TQGMVVHETY RRKSGEWVSP 

       610        620        630        640        650        660 
AELDATMTIE SIATDASGEA KTTTKRKVWL RETGEELEIG PIEKMSKSKR NTVDPDDIIG 

       670        680        690        700        710        720 
TYGADTARWF MLSDSPPDRD VIWSEEGVKG ASRFVQRLWR IANDAAEIAK LAPADRPAEF 

       730        740        750        760        770        780 
GPDAIAVRKA AHGALHKVLN GIERLAFNVS LAHIREFANA LADSLGKADK PTPDLAFAIR 

       790        800        810        820        830        840 
EAAIILVQLV APMMPHLAEE CWEVLGQAGL VSEAGWPAVE PALLVEDTIT LPVQVNGKKR 

       850        860        870        880 
GDVTVARDAQ NPQIEAAVLA LDTVKQALDG KPVRKIIIVP QRIVNVVV 

« Hide

References

[1]"Complete sequence of Rhodopseudomonas palustris BisA53."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Pelletier D.A., Kyrpides N., Kim E., Harwood C.S., Oda Y., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BisA53.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000463 Genomic DNA. Translation: ABJ04349.1.
RefSeqYP_779329.1. NC_008435.1.

3D structure databases

ProteinModelPortalQ07UN5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316055.RPE_0390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ04349; ABJ04349; RPE_0390.
GeneID4357734.
KEGGrpe:RPE_0390.
PATRIC23255266. VBIRhoPal93214_0399.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycRPAL316055:GHR9-393-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_RHOP5
AccessionPrimary (citable) accession number: Q07UN5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries