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Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei303 – 3031ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPAL316055:GHR9-745-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:lysSUniRule annotation
Ordered Locus Names:RPE_0736Imported
OrganismiRhodopseudomonas palustris (strain BisA53)Imported
Taxonomic identifieri316055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000000654: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi316055.RPE_0736.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 599"HIGH" regionUniRule annotation
Motifi300 – 3045"KMSKS" regionUniRule annotation

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1384.
HOGENOMiHOG000140447.
KOiK04566.
OMAiTMVRHAF.
OrthoDBiEOG6WHNM6.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07TP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTDLAQNP AELRALAEQS NAWPFEQAKA LVARLNKAPK DEVLFETGYG
60 70 80 90 100
PSGLPHIGTF GEVARTTMVR HAFRVLTEDK IKTRLIAFSD DMDGLRKVPD
110 120 130 140 150
NVPNKELLSQ HLGKSLSSVP DPFGTHESFG AHNNARLRAF LDTFSFDYEF
160 170 180 190 200
ASATDYYKSG RFDATLLKVL QRLDKVMAIM LPSLREERAA SYSPFLPICP
210 220 230 240 250
RTGVVLQVPI AAHDVAAGTI SYDDPETNER VTLPVTGGHC KLQWKPDWAM
260 270 280 290 300
RWTALGIDYE MAGKDLIDSV KLSGKICQAI GGTPPEGFNY ELFLDDKGQK
310 320 330 340 350
ISKSKGNGLT IDEWLRYASP ESLSLFMYRE PKAAKRLYFD VIPRNVDDYQ
360 370 380 390 400
QFLDGFSRQD AKQQLSNPVW HIHAGQPPKA DMPVTFQLLL TLVSSSNAEN
410 420 430 440 450
AATLWGFIGR YRPGVSPQTH PKLDAMVGYA INYYRDFVAP TKSFREPTDQ
460 470 480 490 500
ERAALQDLRD ALSHLPAEST AEAIQDVVYE IGRREPFLDH KKAAKDGKPG
510 520 530 540
VSLDWFNMLY QVLLGQEKGP RFGSFVAVYG LANAVAMIDG ALARSA
Length:546
Mass (Da):60,716
Last modified:October 31, 2006 - v1
Checksum:i37639DB03E7C97B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000463 Genomic DNA. Translation: ABJ04693.1.
RefSeqiYP_779673.1. NC_008435.1.

Genome annotation databases

EnsemblBacteriaiABJ04693; ABJ04693; RPE_0736.
GeneIDi4358348.
KEGGirpe:RPE_0736.
PATRICi23255982. VBIRhoPal93214_0751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000463 Genomic DNA. Translation: ABJ04693.1.
RefSeqiYP_779673.1. NC_008435.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316055.RPE_0736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ04693; ABJ04693; RPE_0736.
GeneIDi4358348.
KEGGirpe:RPE_0736.
PATRICi23255982. VBIRhoPal93214_0751.

Phylogenomic databases

eggNOGiCOG1384.
HOGENOMiHOG000140447.
KOiK04566.
OMAiTMVRHAF.
OrthoDBiEOG6WHNM6.

Enzyme and pathway databases

BioCyciRPAL316055:GHR9-745-MONOMER.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisA53Imported.

Entry informationi

Entry nameiQ07TP1_RHOP5
AccessioniPrimary (citable) accession number: Q07TP1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: February 4, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.