ID   HGD_RHOP5               Reviewed;         448 AA.
AC   Q07T66;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   05-MAY-2009, entry version 16.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=RPE_0912;
OS   Rhodopseudomonas palustris (strain BisA53).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Pelletier D.A., Kyrpides N., Kim E.,
RA   Harwood C.S., Oda Y., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisA53.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000463; ABJ04868.1; -; Genomic_DNA.
DR   RefSeq; YP_779848.1; -.
DR   GeneID; 4357772; -.
DR   GenomeReviews; CP000463_GR; RPE_0912.
DR   KEGG; rpe:RPE_0912; -.
DR   HOGENOM; Q07T66; -.
DR   OMA; Q07T66; HRNCMSE.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    448       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000019541.
FT   METAL       346    346       Iron (By similarity).
FT   METAL       352    352       Iron (By similarity).
FT   METAL       382    382       Iron (By similarity).
SQ   SEQUENCE   448 AA;  49438 MW;  8AD41FEE444CD97C CRC64;
     MNINTVPELI GRGSASITPG YMSGFKNSFE TEALPGALPI GRNSPQRCAY GLYAEQLSGS
     PFTAPRGSNE RSWLYRIRPS VKHSGRFAKA DVGLWRTAPC HEHEMPIAQL RWDPPPLPQH
     EQTFLQGVVT MTTAGDANTQ AGMAAHIYLI TASMVDQAFY NADGELMFVP QQGSLRFVTE
     FGRIDAGPGE IVVIPRGVKF RVELTGGPAR GYLCENYGGA FTLPERGPIG ANCLANARDF
     LTPVAAYEDK DTPTELFVKW GGTLWATTLP YSPIDVVAWH GNYAPYKYDL RTFSPVGAIG
     FDHPDPSIFT VLTAPSETPG TANIDFVIFP ERWMVADNTF RPPWYHMNIM SEFMGLIYGV
     YDAKPQGFVP GGASLHNMML PHGPDREAFD HASNGELKPT KLTGTMAFMF ETRYPQRVTE
     YAATSGLLQP DYADCWTGLE KRFDPTRP
//