Reviewed, UniProtKB/Swiss-Prot Q07T66 (HGD_RHOP5)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	RPE_0912

Organism

Rhodopseudomonas palustris (strain BisA53) [Complete proteome] [HAMAP]

Taxonomic identifier

316055 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O(2) = 4-maleylacetoacetate.
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Homogentisate 1,2-dioxygenase		PRO_1000019541
Sites
	Metal binding	346	1	Iron By similarity
	Metal binding	352	1	Iron By similarity
	Metal binding	382	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07T66-1 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 8AD41FEE444CD97C	FASTA	448	49,438
	10 20 30 40 50 60 MNINTVPELI GRGSASITPG YMSGFKNSFE TEALPGALPI GRNSPQRCAY GLYAEQLSGS 70 80 90 100 110 120 PFTAPRGSNE RSWLYRIRPS VKHSGRFAKA DVGLWRTAPC HEHEMPIAQL RWDPPPLPQH 130 140 150 160 170 180 EQTFLQGVVT MTTAGDANTQ AGMAAHIYLI TASMVDQAFY NADGELMFVP QQGSLRFVTE 190 200 210 220 230 240 FGRIDAGPGE IVVIPRGVKF RVELTGGPAR GYLCENYGGA FTLPERGPIG ANCLANARDF 250 260 270 280 290 300 LTPVAAYEDK DTPTELFVKW GGTLWATTLP YSPIDVVAWH GNYAPYKYDL RTFSPVGAIG 310 320 330 340 350 360 FDHPDPSIFT VLTAPSETPG TANIDFVIFP ERWMVADNTF RPPWYHMNIM SEFMGLIYGV 370 380 390 400 410 420 YDAKPQGFVP GGASLHNMML PHGPDREAFD HASNGELKPT KLTGTMAFMF ETRYPQRVTE 430 440 YAATSGLLQP DYADCWTGLE KRFDPTRP

References

[1]

"Complete sequence of Rhodopseudomonas palustris BisA53." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Pelletier D.A., Kyrpides N., Kim E., Harwood C.S., Oda Y., Richardson P. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000463 Genomic DNA. Translation: ABJ04868.1.
RefSeq	YP_779848.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4357772.
GenomeReviews	Gene locus RPE_0912 in contig CP000463_GR.
KEGG	rpe:RPE_0912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q07T66.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_RHOP5

Accession

Primary (citable) accession number: Q07T66

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 31, 2006
Last modified:	November 4, 2008
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)