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Q07T66

- HGD_RHOP5

UniProt

Q07T66 - HGD_RHOP5

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Protein

Homogentisate 1,2-dioxygenase

Gene
hmgA, RPE_0912
Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031Proton acceptor By similarity
Metal bindingi346 – 3461Iron By similarity
Metal bindingi352 – 3521Iron By similarity
Binding sitei361 – 3611homogentisate By similarity
Metal bindingi382 – 3821Iron By similarity
Binding sitei382 – 3821homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciRPAL316055:GHR9-927-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:RPE_0912
OrganismiRhodopseudomonas palustris (strain BisA53)
Taxonomic identifieri316055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000000654: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Homogentisate 1,2-dioxygenaseUniRule annotationPRO_1000019541Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi316055.RPE_0912.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiTTETHKL.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07T66-1 [UniParc]FASTAAdd to Basket

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MNINTVPELI GRGSASITPG YMSGFKNSFE TEALPGALPI GRNSPQRCAY    50
GLYAEQLSGS PFTAPRGSNE RSWLYRIRPS VKHSGRFAKA DVGLWRTAPC 100
HEHEMPIAQL RWDPPPLPQH EQTFLQGVVT MTTAGDANTQ AGMAAHIYLI 150
TASMVDQAFY NADGELMFVP QQGSLRFVTE FGRIDAGPGE IVVIPRGVKF 200
RVELTGGPAR GYLCENYGGA FTLPERGPIG ANCLANARDF LTPVAAYEDK 250
DTPTELFVKW GGTLWATTLP YSPIDVVAWH GNYAPYKYDL RTFSPVGAIG 300
FDHPDPSIFT VLTAPSETPG TANIDFVIFP ERWMVADNTF RPPWYHMNIM 350
SEFMGLIYGV YDAKPQGFVP GGASLHNMML PHGPDREAFD HASNGELKPT 400
KLTGTMAFMF ETRYPQRVTE YAATSGLLQP DYADCWTGLE KRFDPTRP 448
Length:448
Mass (Da):49,438
Last modified:October 31, 2006 - v1
Checksum:i8AD41FEE444CD97C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000463 Genomic DNA. Translation: ABJ04868.1.
RefSeqiWP_011662359.1. NC_008435.1.
YP_779848.1. NC_008435.1.

Genome annotation databases

EnsemblBacteriaiABJ04868; ABJ04868; RPE_0912.
GeneIDi4357772.
KEGGirpe:RPE_0912.
PATRICi23256360. VBIRhoPal93214_0933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000463 Genomic DNA. Translation: ABJ04868.1 .
RefSeqi WP_011662359.1. NC_008435.1.
YP_779848.1. NC_008435.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316055.RPE_0912.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ04868 ; ABJ04868 ; RPE_0912 .
GeneIDi 4357772.
KEGGi rpe:RPE_0912.
PATRICi 23256360. VBIRhoPal93214_0933.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi TTETHKL.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci RPAL316055:GHR9-927-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisA53.

Entry informationi

Entry nameiHGD_RHOP5
AccessioniPrimary (citable) accession number: Q07T66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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