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Q07R90

- GCSP_RHOP5

UniProt

Q07R90 - GCSP_RHOP5

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, RPE_1595
Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRPAL316055:GHR9-1612-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:RPE_1595
OrganismiRhodopseudomonas palustris (strain BisA53)
Taxonomic identifieri316055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
ProteomesiUP000000654: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 961961Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi316055.RPE_1595.

Structurei

3D structure databases

ProteinModelPortaliQ07R90.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiKATEHAI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07R90-1 [UniParc]FASTAAdd to Basket

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MPVSRSPIED LANGFARRHI GPSPQEIAAM LRAVGAPSLD ALMGETLPAA    50
IRQAKPLDLG PALSEPEALA HMAELAAKNQ VFTSLIGQGY YGTAMPTVIQ 100
RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD 150
EGTAAAEAMA LAERAMPKKT KAFFVDRDTH PQTLAVLRTR AEPLGWQIIV 200
GDPVSDLQKA DVFGALLQYP GSSGALRDPR PMIAALHAKG GLAVIAADLL 250
ALTLLASPGD LGADIAIGSA QRFGVPMGYG GPHAGFMAVR DSLKRALPGR 300
IVGQSIDSHG QPAYRLALQT REQHIRREKA TSNICTAQVL LAVLASMYAV 350
YHGPEGLSAI ARSIHRKTAV LAAGLRKLGF TTRNEAFFDT ITVDVGDKQS 400
EIIARARDEN INLRIGDGTL GLSLDETTTP KIVEAVWRAF GGALSYAEIE 450
PAMRDALHPT LKRTSPFMTQ EVFHLYRSET ELLRYMRKLS DRDLALDRAM 500
IPLGSCTMKL NATTEMMPLS LPGFAHLHPF APPEQALGYH ALFDKLETWL 550
AEITGYDAVS LQPNSGAQGE YAGLLAIRGY YKSRGEPHRK ICLIPSSAHG 600
TNPASAAMAG MEVVVVECND RGDVDVDDLR ARAELHSPNL AAVMITYPST 650
HGVFEEHIRD ICDIVHAHGG QVYLDGANLN AQVGLARPGE YGADVSHINL 700
HKTFAIPHGG GGPGMGPIGV KAHLAPFLPG HPCCDDTGPD GFSHGGGTVA 750
AAPWGSASVL TISYVYILLM GGDGLKRATE VAILNANYVA AKLDPHFPVL 800
YKNERGRVAH ECIVDPRALK NSSGVTVDDI AKRLIDYGFH APTMSFPVVG 850
TLMIEPTESE SKAELDRFCD AMIAIRREIA EIETGRWKVE QSPLRFAPHT 900
VHDLAEDHWH RPYSRAIGCF PAGTARHDKY WCPVGRIDNV YGDRNLVCSC 950
PPIEDYALAA E 961
Length:961
Mass (Da):103,714
Last modified:October 31, 2006 - v1
Checksum:i1DDFC24A10AD6A57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000463 Genomic DNA. Translation: ABJ05544.1.
RefSeqiYP_780524.1. NC_008435.1.

Genome annotation databases

EnsemblBacteriaiABJ05544; ABJ05544; RPE_1595.
GeneIDi4358882.
KEGGirpe:RPE_1595.
PATRICi23257728. VBIRhoPal93214_1616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000463 Genomic DNA. Translation: ABJ05544.1 .
RefSeqi YP_780524.1. NC_008435.1.

3D structure databases

ProteinModelPortali Q07R90.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316055.RPE_1595.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ05544 ; ABJ05544 ; RPE_1595 .
GeneIDi 4358882.
KEGGi rpe:RPE_1595.
PATRICi 23257728. VBIRhoPal93214_1616.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi KATEHAI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RPAL316055:GHR9-1612-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BisA53.

Entry informationi

Entry nameiGCSP_RHOP5
AccessioniPrimary (citable) accession number: Q07R90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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