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Q07R90 (GCSP_RHOP5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:RPE_1595
OrganismRhodopseudomonas palustris (strain BisA53) [Complete proteome] [HAMAP]
Taxonomic identifier316055 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas

Protein attributes

Sequence length961 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 961961Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045601

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07R90 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 1DDFC24A10AD6A57

FASTA961103,714
        10         20         30         40         50         60 
MPVSRSPIED LANGFARRHI GPSPQEIAAM LRAVGAPSLD ALMGETLPAA IRQAKPLDLG 

        70         80         90        100        110        120 
PALSEPEALA HMAELAAKNQ VFTSLIGQGY YGTAMPTVIQ RNILENPAWY TAYTPYQPEI 

       130        140        150        160        170        180 
SQGRLEALFN FQTMICDLTG LDVANASLLD EGTAAAEAMA LAERAMPKKT KAFFVDRDTH 

       190        200        210        220        230        240 
PQTLAVLRTR AEPLGWQIIV GDPVSDLQKA DVFGALLQYP GSSGALRDPR PMIAALHAKG 

       250        260        270        280        290        300 
GLAVIAADLL ALTLLASPGD LGADIAIGSA QRFGVPMGYG GPHAGFMAVR DSLKRALPGR 

       310        320        330        340        350        360 
IVGQSIDSHG QPAYRLALQT REQHIRREKA TSNICTAQVL LAVLASMYAV YHGPEGLSAI 

       370        380        390        400        410        420 
ARSIHRKTAV LAAGLRKLGF TTRNEAFFDT ITVDVGDKQS EIIARARDEN INLRIGDGTL 

       430        440        450        460        470        480 
GLSLDETTTP KIVEAVWRAF GGALSYAEIE PAMRDALHPT LKRTSPFMTQ EVFHLYRSET 

       490        500        510        520        530        540 
ELLRYMRKLS DRDLALDRAM IPLGSCTMKL NATTEMMPLS LPGFAHLHPF APPEQALGYH 

       550        560        570        580        590        600 
ALFDKLETWL AEITGYDAVS LQPNSGAQGE YAGLLAIRGY YKSRGEPHRK ICLIPSSAHG 

       610        620        630        640        650        660 
TNPASAAMAG MEVVVVECND RGDVDVDDLR ARAELHSPNL AAVMITYPST HGVFEEHIRD 

       670        680        690        700        710        720 
ICDIVHAHGG QVYLDGANLN AQVGLARPGE YGADVSHINL HKTFAIPHGG GGPGMGPIGV 

       730        740        750        760        770        780 
KAHLAPFLPG HPCCDDTGPD GFSHGGGTVA AAPWGSASVL TISYVYILLM GGDGLKRATE 

       790        800        810        820        830        840 
VAILNANYVA AKLDPHFPVL YKNERGRVAH ECIVDPRALK NSSGVTVDDI AKRLIDYGFH 

       850        860        870        880        890        900 
APTMSFPVVG TLMIEPTESE SKAELDRFCD AMIAIRREIA EIETGRWKVE QSPLRFAPHT 

       910        920        930        940        950        960 
VHDLAEDHWH RPYSRAIGCF PAGTARHDKY WCPVGRIDNV YGDRNLVCSC PPIEDYALAA 


E 

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References

[1]"Complete sequence of Rhodopseudomonas palustris BisA53."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Pelletier D.A., Kyrpides N., Kim E., Harwood C.S., Oda Y., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BisA53.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000463 Genomic DNA. Translation: ABJ05544.1.
RefSeqYP_780524.1. NC_008435.1.

3D structure databases

ProteinModelPortalQ07R90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316055.RPE_1595.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ05544; ABJ05544; RPE_1595.
GeneID4358882.
KEGGrpe:RPE_1595.
PATRIC23257728. VBIRhoPal93214_1616.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAKATEHAI.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycRPAL316055:GHR9-1612-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHOP5
AccessionPrimary (citable) accession number: Q07R90
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families