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Q07R90

- GCSP_RHOP5

UniProt

Q07R90 - GCSP_RHOP5

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRPAL316055:GHR9-1612-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:RPE_1595
    OrganismiRhodopseudomonas palustris (strain BisA53)
    Taxonomic identifieri316055 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000000654: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 961961Glycine dehydrogenase (decarboxylating)PRO_1000045601Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi316055.RPE_1595.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07R90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiKATEHAI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q07R90-1 [UniParc]FASTAAdd to Basket

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    MPVSRSPIED LANGFARRHI GPSPQEIAAM LRAVGAPSLD ALMGETLPAA    50
    IRQAKPLDLG PALSEPEALA HMAELAAKNQ VFTSLIGQGY YGTAMPTVIQ 100
    RNILENPAWY TAYTPYQPEI SQGRLEALFN FQTMICDLTG LDVANASLLD 150
    EGTAAAEAMA LAERAMPKKT KAFFVDRDTH PQTLAVLRTR AEPLGWQIIV 200
    GDPVSDLQKA DVFGALLQYP GSSGALRDPR PMIAALHAKG GLAVIAADLL 250
    ALTLLASPGD LGADIAIGSA QRFGVPMGYG GPHAGFMAVR DSLKRALPGR 300
    IVGQSIDSHG QPAYRLALQT REQHIRREKA TSNICTAQVL LAVLASMYAV 350
    YHGPEGLSAI ARSIHRKTAV LAAGLRKLGF TTRNEAFFDT ITVDVGDKQS 400
    EIIARARDEN INLRIGDGTL GLSLDETTTP KIVEAVWRAF GGALSYAEIE 450
    PAMRDALHPT LKRTSPFMTQ EVFHLYRSET ELLRYMRKLS DRDLALDRAM 500
    IPLGSCTMKL NATTEMMPLS LPGFAHLHPF APPEQALGYH ALFDKLETWL 550
    AEITGYDAVS LQPNSGAQGE YAGLLAIRGY YKSRGEPHRK ICLIPSSAHG 600
    TNPASAAMAG MEVVVVECND RGDVDVDDLR ARAELHSPNL AAVMITYPST 650
    HGVFEEHIRD ICDIVHAHGG QVYLDGANLN AQVGLARPGE YGADVSHINL 700
    HKTFAIPHGG GGPGMGPIGV KAHLAPFLPG HPCCDDTGPD GFSHGGGTVA 750
    AAPWGSASVL TISYVYILLM GGDGLKRATE VAILNANYVA AKLDPHFPVL 800
    YKNERGRVAH ECIVDPRALK NSSGVTVDDI AKRLIDYGFH APTMSFPVVG 850
    TLMIEPTESE SKAELDRFCD AMIAIRREIA EIETGRWKVE QSPLRFAPHT 900
    VHDLAEDHWH RPYSRAIGCF PAGTARHDKY WCPVGRIDNV YGDRNLVCSC 950
    PPIEDYALAA E 961
    Length:961
    Mass (Da):103,714
    Last modified:October 31, 2006 - v1
    Checksum:i1DDFC24A10AD6A57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000463 Genomic DNA. Translation: ABJ05544.1.
    RefSeqiYP_780524.1. NC_008435.1.

    Genome annotation databases

    EnsemblBacteriaiABJ05544; ABJ05544; RPE_1595.
    GeneIDi4358882.
    KEGGirpe:RPE_1595.
    PATRICi23257728. VBIRhoPal93214_1616.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000463 Genomic DNA. Translation: ABJ05544.1 .
    RefSeqi YP_780524.1. NC_008435.1.

    3D structure databases

    ProteinModelPortali Q07R90.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316055.RPE_1595.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ05544 ; ABJ05544 ; RPE_1595 .
    GeneIDi 4358882.
    KEGGi rpe:RPE_1595.
    PATRICi 23257728. VBIRhoPal93214_1616.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi KATEHAI.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci RPAL316055:GHR9-1612-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisA53.

    Entry informationi

    Entry nameiGCSP_RHOP5
    AccessioniPrimary (citable) accession number: Q07R90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3