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Protein

Fumarate hydratase class II

Gene

fumC

Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.UniRule annotation

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.UniRule annotation

Catalytic activityi

(S)-malate = fumarate + H2O.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from fumarate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Fumarate hydratase class II (fumC)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from fumarate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei198SubstrateUniRule annotation1
Active sitei199Proton donor/acceptorUniRule annotation1
Active sitei329UniRule annotation1
Binding sitei330SubstrateUniRule annotation1
Sitei342Important for catalytic activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

BioCyciRPAL316055:G1G7C-2171-MONOMER
UniPathwayiUPA00223; UER01007

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase class IIUniRule annotation (EC:4.2.1.2UniRule annotation)
Short name:
Fumarase CUniRule annotation
Alternative name(s):
Aerobic fumaraseUniRule annotation
Iron-independent fumaraseUniRule annotation
Gene namesi
Name:fumCUniRule annotation
Ordered Locus Names:RPE_2144Imported
OrganismiRhodopseudomonas palustris (strain BisA53)Imported
Taxonomic identifieri316055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000000654 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi316055.RPE_2144

Structurei

3D structure databases

ProteinModelPortaliQ07PP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 353Lyase_1InterPro annotationAdd BLAST331
Domaini419 – 472FumaraseC_CInterPro annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 111Substrate bindingUniRule annotation3
Regioni140 – 143Substrate binding (B site)UniRule annotation4
Regioni150 – 152Substrate bindingUniRule annotation3
Regioni335 – 337Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9Q Bacteria
COG0114 LUCA
HOGENOMiHOG000061736
KOiK01679
OMAiVSFTDNC
OrthoDBiPOG091H01XG

Family and domain databases

CDDicd01362 Fumarase_classII, 1 hit
Gene3Di1.10.275.10, 1 hit
HAMAPiMF_00743 FumaraseC, 1 hit
InterProiView protein in InterPro
IPR005677 Fum_hydII
IPR024083 Fumarase/histidase_N
IPR018951 Fumarase_C_C
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR11444 PTHR11444, 1 hit
PfamiView protein in Pfam
PF10415 FumaraseC_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00979 fumC_II, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q07PP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSPKPTSG KPPASRSETD SFGAIEVPAD RYWGAQTERS RQNFKIGHDR
60 70 80 90 100
MPMPVVRALA LVKLAAAETN RDLGLLDQRR ARAIVKAARE IIDGRLDGHF
110 120 130 140 150
PLVVWQTGSG TQSNMNLNEV IANRANELLG APLGGKKPVH PNDHVNMSQS
160 170 180 190 200
SNDSFPTAMH IAAMQQITAE LLPALTLLAR ALRKKEKAFA KIVKIGRTHT
210 220 230 240 250
QDATPLTLGQ EFSGYAAQVE NGLARLKEAS KALYPLAQGG TAVGTGLNAH
260 270 280 290 300
PKFARLFAKR AASLTRLPFT SAPNKFEALA SNDAYVYVHG AINAVAAALF
310 320 330 340 350
KIANDIRLLG SGPRSGLGEL LLPENEPGSS IMPGKVNPTQ CEAITMVCCQ
360 370 380 390 400
VFGHHTTITV AGSQGHFELN VYKPVMAHCM IGSIELLADA TRSFTTHCID
410 420 430 440 450
GIRANEKQIQ QSMERSLMLV TALAPSIGYD NAAKIAKTAH ERGTTLKHEA
460 470
VRLGMVSEAE FDRLVRPDRM THPR
Length:474
Mass (Da):51,192
Last modified:October 31, 2006 - v1
Checksum:iF6999A312226E6C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000463 Genomic DNA Translation: ABJ06088.1
RefSeqiWP_011663571.1, NC_008435.1

Genome annotation databases

EnsemblBacteriaiABJ06088; ABJ06088; RPE_2144
KEGGirpe:RPE_2144

Similar proteinsi

Entry informationi

Entry nameiQ07PP6_RHOP5
AccessioniPrimary (citable) accession number: Q07PP6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: February 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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