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Q07L39

- PANC_RHOP5

UniProt

Q07L39 - PANC_RHOP5

Protein

Pantothenate synthetase

Gene

panC

Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei41 – 411Proton donorUniRule annotation
    Binding sitei65 – 651Beta-alanineUniRule annotation
    Binding sitei65 – 651PantoateUniRule annotation
    Binding sitei158 – 1581PantoateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 418ATPUniRule annotation
    Nucleotide bindingi152 – 1554ATPUniRule annotation
    Nucleotide bindingi189 – 1924ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRPAL316055:GHR9-3446-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:RPE_3413
    OrganismiRhodopseudomonas palustris (strain BisA53)
    Taxonomic identifieri316055 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
    ProteomesiUP000000654: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Pantothenate synthetasePRO_0000305533Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi316055.RPE_3413.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07L39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q07L39-1 [UniParc]FASTAAdd to Basket

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    MSRSPIVART LPALRRALDT IRARKASVAL VPTMGALHEG HLALVRLAKR    50
    RASKVVVSIF VNPAQFAPNE DFASYPRTWK ADLAKLAAEK VDLVWNPDAK 100
    TMYPAGFASK IITEGPALVG LEDRFRPQFF GGVTTVVGKL FAQVRPDFAL 150
    FGEKDFQQLR VVTRMARDLD LGAKVIGVPT MRERDGLAMS SRNVYLSPEH 200
    RSAAPTLYRS LKEAAKRLRA GDDIDVALGG GAEMITAAGF KLDYLEARHA 250
    ETLEPIASLE DGPIRLLVAA RIGSTRLIDN VAV 283
    Length:283
    Mass (Da):30,858
    Last modified:October 2, 2007 - v2
    Checksum:i3EBCDB62D495E44F
    GO

    Sequence cautioni

    The sequence ABJ07345.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000463 Genomic DNA. Translation: ABJ07345.1. Different initiation.
    RefSeqiYP_782325.1. NC_008435.1.

    Genome annotation databases

    EnsemblBacteriaiABJ07345; ABJ07345; RPE_3413.
    GeneIDi4361099.
    KEGGirpe:RPE_3413.
    PATRICi23261436. VBIRhoPal93214_3455.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000463 Genomic DNA. Translation: ABJ07345.1 . Different initiation.
    RefSeqi YP_782325.1. NC_008435.1.

    3D structure databases

    ProteinModelPortali Q07L39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316055.RPE_3413.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ07345 ; ABJ07345 ; RPE_3413 .
    GeneIDi 4361099.
    KEGGi rpe:RPE_3413.
    PATRICi 23261436. VBIRhoPal93214_3455.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci RPAL316055:GHR9-3446-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BisA53.

    Entry informationi

    Entry nameiPANC_RHOP5
    AccessioniPrimary (citable) accession number: Q07L39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3