Q07K31 (GLPK_RHOP5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	RPE_3774

Organism

Rhodopseudomonas palustris (strain BisA53) [Complete proteome] [HAMAP]

Taxonomic identifier

316055 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas › Rhodopseudomonas palustris

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP-Rule MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP-Rule MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP-Rule MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycerol catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP glycerol kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Glycerol kinase HAMAP-Rule MF_00186		PRO_1000020766
Regions
	Nucleotide binding	411 – 415	5	ATP By similarity
Sites
	Binding site	11	1	Substrate By similarity
	Binding site	15	1	ATP By similarity
	Binding site	81	1	Substrate By similarity
	Binding site	133	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity
	Binding site	264	1	ATP By similarity
	Binding site	307	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q07K31 [UniParc]. Last modified October 31, 2006. Version 1. Checksum: 3EE4C2F1E5D927C5	FASTA	500	54,025
	10 20 30 40 50 60 MSFVLAIDQG TTSSRAIVFR DDISIAAVAQ QEFSQHFPAS GWVEHEPEDI WSSTLATSRA 70 80 90 100 110 120 AIEQAGLKAS DIAAIGITNQ RETVVLWDRV TGQAIHRAIV WQDRRTSEIC ARLKSEGHEP 130 140 150 160 170 180 LITQKTGLII DPYFSGTKIG WLLDQVPGAR ARAERGELLF GTVDCYLLWR LTGGKIHATD 190 200 210 220 230 240 ATNASRTLLF NIHTGQWDAE LLALLNVPRS LLPEVKDSSA DFGTSDQNLF GGSIAIRGIA 250 260 270 280 290 300 GDQQAATIGQ ACFAPGMMKS TYGTGCFALL NTGSTPVKSN NKLLTTIAYQ LNGQRTYALE 310 320 330 340 350 360 GSIFVAGSAV QWLRDGLGII SHASETGPLA DKSDSTQSVY LVPAFVGLGA PYWNPRLRGA 370 380 390 400 410 420 LFGLTRNTGP AELAHAALES VCYQTFDLWA AMRADWPDAD EASIVLRVDG GMTASDWTMQ 430 440 450 460 470 480 RLADLLDAPV DRPMIQETTA LGAAYLAGLS AGIFPEPQQF ADNWRLQHRF KPSMSAATRA 490 500 RKLKGWAAAV RGLLATDEGE

References

[1]

"Complete sequence of Rhodopseudomonas palustris BisA53." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Pelletier D.A., Kyrpides N., Kim E., Harwood C.S., Oda Y., Richardson P. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BisA53.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000463 Genomic DNA. Translation: ABJ07703.1.
RefSeq	YP_782683.1. NC_008435.1.
3D structure databases
ProteinModelPortal	Q07K31.
SMR	Q07K31. Positions 3-493.
ModBase	Search...
Protein-protein interaction databases
STRING	316055.RPE_3774.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ07703; ABJ07703; RPE_3774.
GeneID	4361466.
KEGG	rpe:RPE_3774.
PATRIC	23262172. VBIRhoPal93214_3817.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0554.
HOGENOM	HOG000222134.
KO	K00864.
OMA	GQKEFTQ.
ProtClustDB	CLSK818559.
Enzyme and pathway databases
BioCyc	RPAL316055:GHR9-3813-MONOMER.
UniPathway	UPA00618; UER00672.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin.
InterPro	IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
PANTHER	PTHR10196:SF9. PTHR10196:SF9. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_RHOP5

Accession

Primary (citable) accession number: Q07K31

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 31, 2006
Last modified:	May 29, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program