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Q07H58 (HEMH_RHOP5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:RPE_4807
OrganismRhodopseudomonas palustris (strain BisA53) [Complete proteome] [HAMAP]
Taxonomic identifier316055 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bradyrhizobiaceae › Rhodopseudomonas

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Ferrochelatase HAMAP MF_00323
PRO_1000019361

Sites

Metal binding2151Iron By similarity
Metal binding2961Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07H58 [UniParc].

Last modified October 31, 2006. Version 1.
Checksum: 31B81317DC20C885

FASTA34538,371
        10         20         30         40         50         60 
MTVIVPIHSP AVAPAPAPER VGVLLVNLGT PDSCDTKGVR IYLREFLSDP RVIENQGLFW 

        70         80         90        100        110        120 
KLALNGLILQ TRPARKAKDY QKIWNHEKNE SPLKTITRAQ AHKLATSLSD RGHLVVDWAM 

       130        140        150        160        170        180 
RYGNPSMRSR IEAMVAKGCS RLLVVPLYPQ YSAATSATVC DQAFRVLSEL RAQPTMRVAP 

       190        200        210        220        230        240 
PYFRDSAYID ALANSIRSHL ASLPFEPEII VASFHGMPQA YIEKGDPYQA QCIATVDALR 

       250        260        270        280        290        300 
ERMGLGDNKL LLTFQSRFGF DEWLQPYTDQ TIQKLANDGV KRLAVVMPGF ASDCLETLEE 

       310        320        330        340 
IAQENAETFL HNGGEHFSAV PCLNDSDGGI AVIRQLVLRE LQGWL

« Hide

References

[1]"Complete sequence of Rhodopseudomonas palustris BisA53."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Pelletier D.A., Kyrpides N., Kim E., Harwood C.S., Oda Y., Richardson P.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BisA53.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000463 Genomic DNA. Translation: ABJ08726.1.
RefSeqYP_783706.1. NC_008435.1.

3D structure databases

ProteinModelPortalQ07H58.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ07H58.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4362510.
GenomeReviewsGene locus RPE_4807 in contig CP000463_GR.
KEGGrpe:RPE_4807.
PATRIC23264332. VBIRhoPal93214_4883.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycRPAL316055:RPE_4807-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_RHOP5
AccessionPrimary (citable) accession number: Q07H58
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2006
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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