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Protein

Argininosuccinate lyase

Gene

argH

Organism
Rhodopseudomonas palustris (strain BisA53)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:RPE_4842Imported
OrganismiRhodopseudomonas palustris (strain BisA53)Imported
Taxonomic identifieri316055 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeRhodopseudomonas
Proteomesi
  • UP000000654 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi316055.RPE_4842.

Structurei

3D structure databases

ProteinModelPortaliQ07H23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 321Lyase_1InterPro annotationAdd BLAST295
Domaini384 – 453ASL_C2InterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CH7. Bacteria.
COG0165. LUCA.
HOGENOMiHOG000242744.
KOiK01755.
OMAiSIMPHKK.
OrthoDBiPOG091H026A.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814. PTHR43814. 1 hit.
PfamiView protein in Pfam
PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07H23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKSQVRKSQ LPKSQVRKSM SNKMWGGRFT ERPDAIMEEI NVSIDVDRHL
60 70 80 90 100
YAQDIAASKA HAAMLSSQGI ITANDAKNIT KGLDTILSEI VKGSFEFKRA
110 120 130 140 150
LEDIHMNVEG RLSELIGPAA GRLHTARSRN DQVATDFRLF VRDTIDEIDA
160 170 180 190 200
SLARYQLALA SRALEHADTV MPGFTHLQTA QPVTLGHHLM AYVEMAARDR
210 220 230 240 250
GRFQDARKRL NESPLGAAAL AGTSFPIDRD MTARALGFER PMANSLDAVS
260 270 280 290 300
DRDFVLETLS AASICAVHLS RFAEEIVLWT SPLVGLVRLS DKFTTGSSIM
310 320 330 340 350
PQKRNPDAAE LVRAKTGRVI GALTGLLIVM KGLPLAYQKD MQEDKQGAME
360 370 380 390 400
AFAALSLAVR AMTGMVGDLA PDPARMKAAA GEGYATATDL ADWLVQTLKM
410 420 430 440 450
PFREAHHVTG RIVGLAAEQS VALHELPLKE MQAVEPRITM AALAVLSVES
460 470 480
SVKSRVSYGG TAPKNVRAQA KSWLKRLEKE HKSG
Length:484
Mass (Da):52,832
Last modified:October 31, 2006 - v1
Checksum:iE9F4F0B65AEC30B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000463 Genomic DNA. Translation: ABJ08761.1.

Genome annotation databases

EnsemblBacteriaiABJ08761; ABJ08761; RPE_4842.
KEGGirpe:RPE_4842.

Similar proteinsi

Entry informationi

Entry nameiQ07H23_RHOP5
AccessioniPrimary (citable) accession number: Q07H23
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported