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Protein

Caveolin-1

Gene

CAV1

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-1
Gene namesi
Name:CAV1
OrganismiOrnithorhynchus anatinus (Duckbill platypus)
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi
  • UP000002279 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 104CytoplasmicSequence analysisAdd BLAST103
Intramembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 178CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002603722 – 178Caveolin-1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei5N6-acetyllysineBy similarity1
Modified residuei6PhosphotyrosineBy similarity1
Modified residuei14Phosphotyrosine; by ABL1By similarity1
Modified residuei25PhosphotyrosineBy similarity1
Lipidationi133S-palmitoyl cysteineBy similarity1
Lipidationi143S-palmitoyl cysteineBy similarity1
Lipidationi156S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSOANG00000015032.

Interactioni

Subunit structurei

Homooligomer. Interacts (via the N-terminus) with DPP4; the interaction is direct. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner.By similarity

Protein-protein interaction databases

STRINGi9258.ENSOANP00000023661.

Structurei

3D structure databases

SMRiQ07E02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 94Required for homooligomerizationBy similarityAdd BLAST93
Regioni82 – 94Interaction with CAVIN3By similarityAdd BLAST13

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IV7A. Eukaryota.
ENOG4111HJR. LUCA.
HOGENOMiHOG000036550.
HOVERGENiHBG003422.
InParanoidiQ07E02.
KOiK06278.

Family and domain databases

InterProiView protein in InterPro
IPR001612. Caveolin.
IPR018361. Caveolin_CS.
PANTHERiPTHR10844. PTHR10844. 1 hit.
PfamiView protein in Pfam
PF01146. Caveolin. 1 hit.
PROSITEiView protein in PROSITE
PS01210. CAVEOLIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07E02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGKYVDAE GLLYSVPSRD QGNIYKPHNK TMADDLPEKQ LYDAHTKEID
60 70 80 90 100
LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY
110 120 130 140 150
RLLSALLGIP LALLWGIYFA ILSFLHIWAV VPCIRSYLIE IQCISRVYSI
160 170
CIHTFCDPLF EAIGKVFSNI RATVQKEI
Length:178
Mass (Da):20,380
Last modified:October 31, 2006 - v1
Checksum:i1932C9B9FCC47540
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000185 Genomic DNA. Translation: ABI93674.1.
RefSeqiNP_001229660.1. NM_001242731.1.

Genome annotation databases

GeneIDi100079536.
KEGGioaa:100079536.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCAV1_ORNAN
AccessioniPrimary (citable) accession number: Q07E02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 31, 2006
Last modified: July 5, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families