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Protein

Protein Wnt-2

Gene

WNT2

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Gene namesi
Name:WNT2
OrganismiOrnithorhynchus anatinus (Duckbill platypus)
Taxonomic identifieri9258 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000026034728 – 361Protein Wnt-2Add BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 88By similarity
Disulfide bondi128 ↔ 136By similarity
Disulfide bondi138 ↔ 158By similarity
Disulfide bondi207 ↔ 221By similarity
Disulfide bondi209 ↔ 216By similarity
Lipidationi213O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi295 ↔ 310By similarity
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi325 ↔ 340By similarity
Disulfide bondi327 ↔ 337By similarity
Disulfide bondi332 ↔ 333By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9258.ENSOANP00000013967

Structurei

3D structure databases

SMRiQ07DZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiQ07DZ8
KOiK00182

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR009140 Wnt2
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01842 WNT2PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07DZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASVLGLCL SGPLVLLLAW LAPPVTSSWW YMRAAGSSRV MCDNVPGLVS
60 70 80 90 100
RQRQLCHRHP EVMRSIGLGI AEWTAECQHQ FRQHRWNCNT LDRDHSLFGR
110 120 130 140 150
VLLRSSREAA FVYAISSAGV VFAITRACSQ GELKSCSCDP KKKGSAKDSK
160 170 180 190 200
GTFDWGGCSD NIDYGIKFAR AFVDAKERKG KDARALMNLH NNRAGRKAVK
210 220 230 240 250
RFLKQECKCH GVSGSCTLRT CWLAMADFRK TGDYLWRKYN GAIQVVMNQD
260 270 280 290 300
GTGFTVANKR FKKPTKNDLV YFENSPDYCI KDRDAGSLGT AGRVCNLTSR
310 320 330 340 350
GMDSCEVMCC GRGYDTARVT RMTKCECKFH WCCAVRCQDC LEALDVHTCK
360
APSSASEGAP T
Length:361
Mass (Da):40,114
Last modified:October 31, 2006 - v1
Checksum:i674EF359A8EBE99E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000185 Genomic DNA Translation: ABI93678.1
RefSeqiNP_001229667.1, NM_001242738.1

Genome annotation databases

GeneIDi100077640
KEGGioaa:100077640

Similar proteinsi

Entry informationi

Entry nameiWNT2_ORNAN
AccessioniPrimary (citable) accession number: Q07DZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 31, 2006
Last modified: October 25, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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