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Protein

D-xylulose reductase

Gene

XYL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Xylitol + NAD+ = D-xylulose + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Kineticsi

  1. KM=1.1 mM for D-xylose1 Publication
  2. KM=240 µM for NADH1 Publication
  3. KM=25 mM for xylitol1 Publication
  4. KM=100 µM for NAD1 Publication

    Pathwayi: L-arabinose degradation via L-arabinitol

    This protein is involved in step 4 of the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (fungal route).
    Proteins known to be involved in the 5 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. no protein annotated in this organism
    3. no protein annotated in this organism
    4. D-xylulose reductase (XYL2)
    5. no protein annotated in this organism
    This subpathway is part of the pathway L-arabinose degradation via L-arabinitol, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (fungal route), the pathway L-arabinose degradation via L-arabinitol and in Carbohydrate degradation.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi44Zinc; catalyticBy similarity1
    Metal bindingi69Zinc; catalyticBy similarity1
    Metal bindingi155Zinc; catalyticBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi179 – 184NADSequence analysis6

    GO - Molecular functioni

    • D-xylulose reductase activity Source: SGD
    • zinc ion binding Source: InterPro

    GO - Biological processi

    Keywordsi

    Molecular functionOxidoreductase
    Biological processCarbohydrate metabolism, Xylose metabolism
    LigandMetal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:YLR070C-MONOMER
    ReactomeiR-SCE-5652227 Fructose biosynthesis
    R-SCE-5661270 Catabolism of glucuronate to xylulose-5-phosphate
    SABIO-RKQ07993
    UniPathwayiUPA00146; UER00577

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-xylulose reductase (EC:1.1.1.9)
    Alternative name(s):
    Xylitol dehydrogenase
    Short name:
    XDH
    Gene namesi
    Name:XYL2
    Ordered Locus Names:YLR070C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome XII

    Organism-specific databases

    EuPathDBiFungiDB:YLR070C
    SGDiS000004060 XYL2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002709251 – 356D-xylulose reductaseAdd BLAST356

    Proteomic databases

    PaxDbiQ07993
    PRIDEiQ07993

    Expressioni

    Inductioni

    By xylose.1 Publication

    Interactioni

    Protein-protein interaction databases

    BioGridi31344, 73 interactors
    DIPiDIP-4533N
    IntActiQ07993, 2 interactors
    STRINGi4932.YLR070C

    Structurei

    3D structure databases

    ProteinModelPortaliQ07993
    SMRiQ07993
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00550000074781
    HOGENOMiHOG000294670
    InParanoidiQ07993
    KOiK05351
    OMAiGLNMIRK
    OrthoDBiEOG092C2LBV

    Family and domain databases

    InterProiView protein in InterPro
    IPR013149 ADH_C
    IPR013154 ADH_N
    IPR002328 ADH_Zn_CS
    IPR011032 GroES-like_sf
    IPR036291 NAD(P)-bd_dom_sf
    IPR020843 PKS_ER
    PfamiView protein in Pfam
    PF08240 ADH_N, 1 hit
    PF00107 ADH_zinc_N, 1 hit
    SMARTiView protein in SMART
    SM00829 PKS_ER, 1 hit
    SUPFAMiSSF50129 SSF50129, 1 hit
    SSF51735 SSF51735, 1 hit
    PROSITEiView protein in PROSITE
    PS00059 ADH_ZINC, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q07993-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MTDLTTQEAI VLERPGKITL TNVSIPKISD PNEVIIQIKA TGICGSDIHY
    60 70 80 90 100
    YTHGRIANYV VESPMVLGHE SSGIVALIGE NVKTLKVGDR VALEPGIPDR
    110 120 130 140 150
    FSPEMKEGRY NLDPNLKFAA TPPFDGTLTK YYKTMKDFVY KLPDDVSFEE
    160 170 180 190 200
    GALIEPLSVA IHANKLAKIK FGARCVVFGA GPIGLLAGKV ASVFGAADVV
    210 220 230 240 250
    FVDLLENKLE TARQFGATHI VNSGDLPHGV TVDSVIKKAI GKKGADVVFE
    260 270 280 290 300
    CSGAEPCVRA GIEVCKAGGT IVQVGMGQEE IQFPISIIPT KELTFQGCFR
    310 320 330 340 350
    YCQGDYSDSI ELVSSRKLSL KPFITHRYSF KDAVEAFEET SHHPLNNIKT

    IIEGPE
    Length:356
    Mass (Da):38,600
    Last modified:November 1, 1996 - v1
    Checksum:i5DFD19BDB2E0AE00
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z73242 Genomic DNA Translation: CAA97627.1
    BK006945 Genomic DNA Translation: DAA09387.1
    PIRiS64902
    RefSeqiNP_013171.1, NM_001181957.1

    Genome annotation databases

    EnsemblFungiiYLR070C; YLR070C; YLR070C
    GeneIDi850759
    KEGGisce:YLR070C

    Similar proteinsi

    Entry informationi

    Entry nameiXYL2_YEAST
    AccessioniPrimary (citable) accession number: Q07993
    Secondary accession number(s): D6VY71
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: November 1, 1996
    Last modified: May 23, 2018
    This is version 137 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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