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Q07993 (XYL2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-xylulose reductase

EC=1.1.1.9
Alternative name(s):
Xylitol dehydrogenase
Short name=XDH
Gene names
Name:XYL2
Ordered Locus Names:YLR070C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Xylitol + NAD+ = D-xylulose + NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.

Induction

By xylose. Ref.3

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Biophysicochemical properties

Kinetic parameters:

KM=1.1 mM for D-xylose Ref.3

KM=240 µM for NADH

KM=25 mM for xylitol

KM=100 µM for NAD

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356D-xylulose reductase
PRO_0000270925

Regions

Nucleotide binding179 – 1846NAD Potential

Sites

Metal binding441Zinc; catalytic By similarity
Metal binding691Zinc; catalytic By similarity
Metal binding1551Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07993 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5DFD19BDB2E0AE00

FASTA35638,600
        10         20         30         40         50         60 
MTDLTTQEAI VLERPGKITL TNVSIPKISD PNEVIIQIKA TGICGSDIHY YTHGRIANYV 

        70         80         90        100        110        120 
VESPMVLGHE SSGIVALIGE NVKTLKVGDR VALEPGIPDR FSPEMKEGRY NLDPNLKFAA 

       130        140        150        160        170        180 
TPPFDGTLTK YYKTMKDFVY KLPDDVSFEE GALIEPLSVA IHANKLAKIK FGARCVVFGA 

       190        200        210        220        230        240 
GPIGLLAGKV ASVFGAADVV FVDLLENKLE TARQFGATHI VNSGDLPHGV TVDSVIKKAI 

       250        260        270        280        290        300 
GKKGADVVFE CSGAEPCVRA GIEVCKAGGT IVQVGMGQEE IQFPISIIPT KELTFQGCFR 

       310        320        330        340        350 
YCQGDYSDSI ELVSSRKLSL KPFITHRYSF KDAVEAFEET SHHPLNNIKT IIEGPE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z73242 Genomic DNA. Translation: CAA97627.1.
BK006945 Genomic DNA. Translation: DAA09387.1.
PIRS64902.
RefSeqNP_013171.1. NM_001181957.1.

3D structure databases

HSSPHSSP built from PDB template 1PL8 based on UniProtKB Q00796.
ProteinModelPortalQ07993.
SMRQ07993. Positions 5-356.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4533N.
IntActQ07993. 2 interactions.
MINTMINT-499230.
STRINGQ07993.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR070C; YLR070C; YLR070C.
GeneID850759.
KEGGsce:YLR070C.
NMPDRfig|4932.3.peg.4162.

Organism-specific databases

CYGDYLR070c.
SGDS000004060. XYL2.

Phylogenomic databases

eggNOGfuNOG06615.
GeneTreeEFGT00050000001794.
HOGENOMHBG753318.
OMATHGRIAN.
OrthoDBEOG4SFDFJ.

Gene expression databases

ArrayExpressQ07993.
GenevestigatorQ07993.

Family and domain databases

InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK05351.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966906.

Entry information

Entry nameXYL2_YEAST
AccessionPrimary (citable) accession number: Q07993
Secondary accession number(s): D6VY71
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families