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Protein

Translocon-associated protein subunit delta

Gene

Ssr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit delta
Short name:
TRAP-delta
Alternative name(s):
Signal sequence receptor subunit delta
Short name:
SSR-delta
Gene namesi
Name:Ssr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi62034. Ssr4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 144121LumenalSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Topological domaini166 – 1738CytoplasmicSequence analysis

GO - Cellular componenti

  • endoplasmic reticulum Source: RGD
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • Sec61 translocon complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 173150Translocon-associated protein subunit deltaPRO_0000033295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 57By similarity
Cross-linki73 – 73Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Disulfide bond, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ07984.
PRIDEiQ07984.

Expressioni

Gene expression databases

BgeeiENSRNOG00000037283.
GenevisibleiQ07984. RN.

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

Protein-protein interaction databases

IntActiQ07984. 1 interaction.
MINTiMINT-4569203.
STRINGi10116.ENSRNOP00000063309.

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-delta family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4088. Eukaryota.
ENOG4111GCB. LUCA.
GeneTreeiENSGT00390000008992.
HOGENOMiHOG000293353.
HOVERGENiHBG002293.
InParanoidiQ07984.
KOiK04571.
OMAiYMAFSAK.
OrthoDBiEOG091G0UKL.

Family and domain databases

InterProiIPR008855. TRAP-delta.
[Graphical view]
PANTHERiPTHR12731. PTHR12731. 1 hit.
PfamiPF05404. TRAP-delta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMASFGAL ALLLLSGLSC CSAEACLEPQ ITPSYYTTSD AVISTETVFI
60 70 80 90 100
VEISLTCKNR VQNMALYADV SGKQFPVTRG QDVGRYQVSW SLEHKSAHAG
110 120 130 140 150
TYEVRFFDEE SYSLLRKAQR NNEDVSIIPP LFTVSVDHRG TWNGPWVSTE
160 170
VLAAAIGIVI YYLAFSAKSH IQA
Length:173
Mass (Da):18,980
Last modified:November 1, 1995 - v1
Checksum:iCE673433DCD47EBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19087 mRNA. Translation: CAA79513.1.
BC058482 mRNA. Translation: AAH58482.1.
PIRiS33295.
RefSeqiNP_058895.1. NM_017199.1.
UniGeneiRn.1999.

Genome annotation databases

EnsembliENSRNOT00000083557; ENSRNOP00000070206; ENSRNOG00000053172.
GeneIDi29435.
KEGGirno:29435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19087 mRNA. Translation: CAA79513.1.
BC058482 mRNA. Translation: AAH58482.1.
PIRiS33295.
RefSeqiNP_058895.1. NM_017199.1.
UniGeneiRn.1999.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ07984. 1 interaction.
MINTiMINT-4569203.
STRINGi10116.ENSRNOP00000063309.

Proteomic databases

PaxDbiQ07984.
PRIDEiQ07984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083557; ENSRNOP00000070206; ENSRNOG00000053172.
GeneIDi29435.
KEGGirno:29435.

Organism-specific databases

CTDi6748.
RGDi62034. Ssr4.

Phylogenomic databases

eggNOGiKOG4088. Eukaryota.
ENOG4111GCB. LUCA.
GeneTreeiENSGT00390000008992.
HOGENOMiHOG000293353.
HOVERGENiHBG002293.
InParanoidiQ07984.
KOiK04571.
OMAiYMAFSAK.
OrthoDBiEOG091G0UKL.

Miscellaneous databases

PROiQ07984.

Gene expression databases

BgeeiENSRNOG00000037283.
GenevisibleiQ07984. RN.

Family and domain databases

InterProiIPR008855. TRAP-delta.
[Graphical view]
PANTHERiPTHR12731. PTHR12731. 1 hit.
PfamiPF05404. TRAP-delta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSRD_RAT
AccessioniPrimary (citable) accession number: Q07984
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.