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Protein

Translocon-associated protein subunit delta

Gene

Ssr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit delta
Short name:
TRAP-delta
Alternative name(s):
Signal sequence receptor subunit delta
Short name:
SSR-delta
Gene namesi
Name:Ssr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi62034 Ssr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 144LumenalSequence analysisAdd BLAST121
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 173CytoplasmicSequence analysis8

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003329524 – 173Translocon-associated protein subunit deltaAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 57By similarity
Cross-linki73Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Disulfide bond, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ07984
PRIDEiQ07984

Expressioni

Gene expression databases

BgeeiENSRNOG00000053172
GenevisibleiQ07984 RN

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

Protein-protein interaction databases

IntActiQ07984, 2 interactors
STRINGi10116.ENSRNOP00000063309

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-delta family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4088 Eukaryota
ENOG4111GCB LUCA
GeneTreeiENSGT00390000008992
HOGENOMiHOG000293353
HOVERGENiHBG002293
InParanoidiQ07984
KOiK04571
OMAiGPWVNSE
OrthoDBiEOG091G0UKL

Family and domain databases

InterProiView protein in InterPro
IPR008855 TRAP-delta
PANTHERiPTHR12731 PTHR12731, 1 hit
PfamiView protein in Pfam
PF05404 TRAP-delta, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMASFGAL ALLLLSGLSC CSAEACLEPQ ITPSYYTTSD AVISTETVFI
60 70 80 90 100
VEISLTCKNR VQNMALYADV SGKQFPVTRG QDVGRYQVSW SLEHKSAHAG
110 120 130 140 150
TYEVRFFDEE SYSLLRKAQR NNEDVSIIPP LFTVSVDHRG TWNGPWVSTE
160 170
VLAAAIGIVI YYLAFSAKSH IQA
Length:173
Mass (Da):18,980
Last modified:November 1, 1995 - v1
Checksum:iCE673433DCD47EBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19087 mRNA Translation: CAA79513.1
BC058482 mRNA Translation: AAH58482.1
PIRiS33295
RefSeqiNP_058895.1, NM_017199.1
UniGeneiRn.1999

Genome annotation databases

EnsembliENSRNOT00000083557; ENSRNOP00000070206; ENSRNOG00000053172
GeneIDi29435
KEGGirno:29435

Similar proteinsi

Entry informationi

Entry nameiSSRD_RAT
AccessioniPrimary (citable) accession number: Q07984
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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