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Protein

DNA mismatch repair protein MLH2

Gene

MLH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of a MutL heterodimer with MLH1, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a role in the repair of heteroduplex sites present in meiotic recombination intermediates and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates.3 Publications

Miscellaneous

Present with 72 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mismatch repair Source: SGD
  • reciprocal meiotic recombination Source: SGD

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-32194-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MLH2
Alternative name(s):
MutL protein homolog 2
Gene namesi
Name:MLH2
Ordered Locus Names:YLR035C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR035C
SGDiS000004025 MLH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455691 – 695DNA mismatch repair protein MLH2Add BLAST695

Proteomic databases

MaxQBiQ07980
PaxDbiQ07980
PRIDEiQ07980

Interactioni

Subunit structurei

Heterodimer of MLH1 and MLH2.

Binary interactionsi

WithEntry#Exp.IntActNotes
MLH1P389205EBI-33369,EBI-11003

Protein-protein interaction databases

BioGridi31309, 84 interactors
DIPiDIP-2413N
IntActiQ07980, 7 interactors
MINTiQ07980
STRINGi4932.YLR035C

Structurei

3D structure databases

ProteinModelPortaliQ07980
SMRiQ07980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000113599
InParanoidiQ07980
OMAiSISNPFM
OrthoDBiEOG092C0WSN

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR002099 DNA_mismatch_repair_N
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR038973 MutL/Mlh/Pms
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073 PTHR10073, 2 hits
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00585 mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q07980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHQLSPES QWKIVSSSFI YGPVAAVREL LDNSIDSGAK KVFIDVDSTT
60 70 80 90 100
GGCEYISVKD DGSGVDIIDR PSMCLEYTTS KMSSLGDISI LTTLGFRGEA
110 120 130 140 150
LFLLSNLCNQ KGSMQVETKT ADDVIGEKWL VDSKGGITNG KRYKVSCPVG
160 170 180 190 200
TTVILRKLLG GLRARYLEIS SRPRKTFDEL IYLINHYSLI HRNIRFYFSL
210 220 230 240 250
VSLQKNGAIE RKQMQETLDP KISRARSLSL LARLKKPVPL NFIVEENFVI
260 270 280 290 300
DEKINLDLIL PRMVPESDVI NIKRRFKFLS VNERALSLNL ETGKTISKLL
310 320 330 340 350
SSIYRDFSLL DPMVWFINLN CDTKLLDVNI EPEKNDVMIK SFEVIFKKIE
360 370 380 390 400
NKLKLLLEER IGIETNMLGD KHVQPSINEK TSPALVIPTP DAENEISKGC
410 420 430 440 450
GAVSGKDKTD IPQKNSDLIV PTFYDEANLE NTTIVAATPS PTKFSEDKAL
460 470 480 490 500
DEQTQLTISS YRSSSSGSMA SEDSTNWRHN FQQELSENSE VAGAGSSTLP
510 520 530 540 550
SSLTYNYIET IPENEDLELS KDASISNPFM ITKIRNVNKK LSENLLEAKR
560 570 580 590 600
TSCGDANKRG MPNERQLSNT EKKELIKLQQ TYGKRNNTVD MTIPRNSKKK
610 620 630 640 650
VTDNYIKKAS CMHKTRPKLM HFSEYTNNYV YTLKNEKIVK HDSDNFAKET
660 670 680 690
LWLRSRDDAT SPSSSLLQAL RAHVKKPGHI EATTNEWCLF TPDSP
Length:695
Mass (Da):78,248
Last modified:November 1, 1996 - v1
Checksum:iDA5DA6AC86603A81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73207 Genomic DNA Translation: CAA97559.1
BK006945 Genomic DNA Translation: DAA09353.1
PIRiS64862
RefSeqiNP_013135.1, NM_001181922.1

Genome annotation databases

EnsemblFungiiYLR035C; YLR035C; YLR035C
GeneIDi850722
KEGGisce:YLR035C

Similar proteinsi

Entry informationi

Entry nameiMLH2_YEAST
AccessioniPrimary (citable) accession number: Q07980
Secondary accession number(s): D6VY37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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