Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-2,8-sialyltransferase 8B

Gene

St8sia2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

Pathway: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • sialyltransferase activity Source: RGD

GO - Biological processi

  • protein glycosylation Source: UniProtKB-UniPathway
  • sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2,8-sialyltransferase 8B (EC:2.4.99.-)
Alternative name(s):
Sialyltransferase 8B
Short name:
SIAT8-B
Sialyltransferase St8Sia II
Short name:
ST8SiaII
Sialyltransferase X
Short name:
STX
Gene namesi
Name:St8sia2
Synonyms:Siat8b, Stx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621843. St8sia2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Transmembranei7 – 2317Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini24 – 375352LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Alpha-2,8-sialyltransferase 8BPRO_0000149288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi157 ↔ 307By similarity
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07977.
PRIDEiQ07977.

PTM databases

PhosphoSiteiQ07977.

Expressioni

Tissue specificityi

Expressed only in newborn brain.

Developmental stagei

Newborn.

Gene expression databases

GenevisibleiQ07977. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016427.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG324948.
HOGENOMiHOG000232070.
HOVERGENiHBG056466.
InParanoidiQ07977.
KOiK06612.
PhylomeDBiQ07977.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQFRSWML AALTLLVVFL IFADISEIEE EIGNSGGRGT IRSAVNSLHS
60 70 80 90 100
KSNRAEVVIN GSSLPAVADR SNESLKHSIQ PASSKWRHNQ TLSLRIRKQI
110 120 130 140 150
LKFLDAEKDI SVLKGTLKPG DIIHYIFDRD STMNVSQNLY ELLPRTSPLK
160 170 180 190 200
NKHFQTCAIV GNSGVLLNSG CGQEIDTHSF VIRCNLAPVQ EYARDVGLKT
210 220 230 240 250
DLVTMNPSVI QRAFEDLVNA TWREKLLQRL HGLNGSILWI PAFMARGGKE
260 270 280 290 300
RVEWVNALIL KHHVNVRTAY PSLRLLHAVR GYWLTNKVHI KRPTTGLLMY
310 320 330 340 350
TLATRFCNQI YLYGFWPFPL DQNQNPVKYH YYDSLKYGYT SQASPHTMPL
360 370
EFKALKSLHE QGALKLTVGQ CDGAT
Length:375
Mass (Da):42,400
Last modified:November 1, 1996 - v1
Checksum:iF7B3AC1E1E503675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13445 mRNA. Translation: AAA42147.1.
PIRiA46727.
RefSeqiNP_476497.1. NM_057156.1.
UniGeneiRn.44391.

Genome annotation databases

GeneIDi117523.
KEGGirno:117523.
UCSCiRGD:621843. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13445 mRNA. Translation: AAA42147.1.
PIRiA46727.
RefSeqiNP_476497.1. NM_057156.1.
UniGeneiRn.44391.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016427.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSiteiQ07977.

Proteomic databases

PaxDbiQ07977.
PRIDEiQ07977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117523.
KEGGirno:117523.
UCSCiRGD:621843. rat.

Organism-specific databases

CTDi8128.
RGDi621843. St8sia2.

Phylogenomic databases

eggNOGiNOG324948.
HOGENOMiHOG000232070.
HOVERGENiHBG056466.
InParanoidiQ07977.
KOiK06612.
PhylomeDBiQ07977.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

NextBioi620309.
PROiQ07977.

Gene expression databases

GenevisibleiQ07977. RN.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Polymerase chain reaction cloning of a developmentally regulated member of the sialyltransferase gene family."
    Livingston B.D., Paulson J.C.
    J. Biol. Chem. 268:11504-11507(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiSIA8B_RAT
AccessioniPrimary (citable) accession number: Q07977
Secondary accession number(s): Q64688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.