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Q07977

- SIA8B_RAT

UniProt

Q07977 - SIA8B_RAT

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Protein

Alpha-2,8-sialyltransferase 8B

Gene
St8sia2, Siat8b, Stx
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

Pathwayi

GO - Molecular functioni

  1. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: Ensembl
  2. sialyltransferase activity Source: RGD

GO - Biological processi

  1. ganglioside biosynthetic process Source: Ensembl
  2. N-glycan processing Source: Ensembl
  3. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_199227. N-Glycan antennae elongation.
REACT_213723. Sialic acid metabolism.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2,8-sialyltransferase 8B (EC:2.4.99.-)
Alternative name(s):
Sialyltransferase 8B
Short name:
SIAT8-B
Sialyltransferase St8Sia II
Short name:
ST8SiaII
Sialyltransferase X
Short name:
STX
Gene namesi
Name:St8sia2
Synonyms:Siat8b, Stx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621843. St8sia2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Cytoplasmic Reviewed prediction
Transmembranei7 – 2317Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini24 – 375352Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of Golgi membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Alpha-2,8-sialyltransferase 8BPRO_0000149288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi157 ↔ 307 By similarity
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi234 – 2341N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ07977.
PRIDEiQ07977.

PTM databases

PhosphoSiteiQ07977.

Expressioni

Tissue specificityi

Expressed only in newborn brain.

Developmental stagei

Newborn.

Gene expression databases

GenevestigatoriQ07977.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016427.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG324948.
HOGENOMiHOG000232070.
HOVERGENiHBG056466.
InParanoidiQ07977.
KOiK06612.
PhylomeDBiQ07977.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07977-1 [UniParc]FASTAAdd to Basket

« Hide

MQLQFRSWML AALTLLVVFL IFADISEIEE EIGNSGGRGT IRSAVNSLHS    50
KSNRAEVVIN GSSLPAVADR SNESLKHSIQ PASSKWRHNQ TLSLRIRKQI 100
LKFLDAEKDI SVLKGTLKPG DIIHYIFDRD STMNVSQNLY ELLPRTSPLK 150
NKHFQTCAIV GNSGVLLNSG CGQEIDTHSF VIRCNLAPVQ EYARDVGLKT 200
DLVTMNPSVI QRAFEDLVNA TWREKLLQRL HGLNGSILWI PAFMARGGKE 250
RVEWVNALIL KHHVNVRTAY PSLRLLHAVR GYWLTNKVHI KRPTTGLLMY 300
TLATRFCNQI YLYGFWPFPL DQNQNPVKYH YYDSLKYGYT SQASPHTMPL 350
EFKALKSLHE QGALKLTVGQ CDGAT 375
Length:375
Mass (Da):42,400
Last modified:November 1, 1996 - v1
Checksum:iF7B3AC1E1E503675
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13445 mRNA. Translation: AAA42147.1.
PIRiA46727.
RefSeqiNP_476497.1. NM_057156.1.
UniGeneiRn.44391.

Genome annotation databases

GeneIDi117523.
KEGGirno:117523.
UCSCiRGD:621843. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13445 mRNA. Translation: AAA42147.1 .
PIRi A46727.
RefSeqi NP_476497.1. NM_057156.1.
UniGenei Rn.44391.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016427.

Protein family/group databases

CAZyi GT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSitei Q07977.

Proteomic databases

PaxDbi Q07977.
PRIDEi Q07977.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 117523.
KEGGi rno:117523.
UCSCi RGD:621843. rat.

Organism-specific databases

CTDi 8128.
RGDi 621843. St8sia2.

Phylogenomic databases

eggNOGi NOG324948.
HOGENOMi HOG000232070.
HOVERGENi HBG056466.
InParanoidi Q07977.
KOi K06612.
PhylomeDBi Q07977.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_199227. N-Glycan antennae elongation.
REACT_213723. Sialic acid metabolism.

Miscellaneous databases

NextBioi 620309.
PROi Q07977.

Gene expression databases

Genevestigatori Q07977.

Family and domain databases

InterProi IPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view ]
Pfami PF00777. Glyco_transf_29. 1 hit.
[Graphical view ]
PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Polymerase chain reaction cloning of a developmentally regulated member of the sialyltransferase gene family."
    Livingston B.D., Paulson J.C.
    J. Biol. Chem. 268:11504-11507(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiSIA8B_RAT
AccessioniPrimary (citable) accession number: Q07977
Secondary accession number(s): Q64688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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