Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q07977 (SIA8B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-2,8-sialyltransferase 8B

EC=2.4.99.-
Alternative name(s):
Sialyltransferase 8B
Short name=SIAT8-B
Sialyltransferase St8Sia II
Short name=ST8SiaII
Sialyltransferase X
Short name=STX
Gene names
Name:St8sia2
Synonyms:Siat8b, Stx
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Tissue specificity

Expressed only in newborn brain.

Developmental stage

Newborn.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Alpha-2,8-sialyltransferase 8B
PRO_0000149288

Regions

Topological domain1 – 66Cytoplasmic Potential
Transmembrane7 – 2317Helical; Signal-anchor for type II membrane protein; Potential
Topological domain24 – 375352Lumenal Potential

Amino acid modifications

Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2191N-linked (GlcNAc...) Potential
Glycosylation2341N-linked (GlcNAc...) Potential
Disulfide bond157 ↔ 307 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q07977 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F7B3AC1E1E503675

FASTA37542,400
        10         20         30         40         50         60 
MQLQFRSWML AALTLLVVFL IFADISEIEE EIGNSGGRGT IRSAVNSLHS KSNRAEVVIN 

        70         80         90        100        110        120 
GSSLPAVADR SNESLKHSIQ PASSKWRHNQ TLSLRIRKQI LKFLDAEKDI SVLKGTLKPG 

       130        140        150        160        170        180 
DIIHYIFDRD STMNVSQNLY ELLPRTSPLK NKHFQTCAIV GNSGVLLNSG CGQEIDTHSF 

       190        200        210        220        230        240 
VIRCNLAPVQ EYARDVGLKT DLVTMNPSVI QRAFEDLVNA TWREKLLQRL HGLNGSILWI 

       250        260        270        280        290        300 
PAFMARGGKE RVEWVNALIL KHHVNVRTAY PSLRLLHAVR GYWLTNKVHI KRPTTGLLMY 

       310        320        330        340        350        360 
TLATRFCNQI YLYGFWPFPL DQNQNPVKYH YYDSLKYGYT SQASPHTMPL EFKALKSLHE 

       370 
QGALKLTVGQ CDGAT 

« Hide

References

[1]"Polymerase chain reaction cloning of a developmentally regulated member of the sialyltransferase gene family."
Livingston B.D., Paulson J.C.
J. Biol. Chem. 268:11504-11507(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13445 mRNA. Translation: AAA42147.1.
PIRA46727.
RefSeqNP_476497.1. NM_057156.1.
UniGeneRn.44391.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016427.

Protein family/group databases

CAZyGT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSiteQ07977.

Proteomic databases

PaxDbQ07977.
PRIDEQ07977.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID117523.
KEGGrno:117523.
UCSCRGD:621843. rat.

Organism-specific databases

CTD8128.
RGD621843. St8sia2.

Phylogenomic databases

eggNOGNOG324948.
HOGENOMHOG000232070.
HOVERGENHBG056466.
InParanoidQ07977.
KOK06612.
PhylomeDBQ07977.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

GenevestigatorQ07977.

Family and domain databases

InterProIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetSearch...

Other

NextBio620309.
PROQ07977.

Entry information

Entry nameSIA8B_RAT
AccessionPrimary (citable) accession number: Q07977
Secondary accession number(s): Q64688
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways