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Q07977

- SIA8B_RAT

UniProt

Q07977 - SIA8B_RAT

Protein

Alpha-2,8-sialyltransferase 8B

Gene

St8sia2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

    Pathwayi

    GO - Molecular functioni

    1. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: Ensembl
    2. sialyltransferase activity Source: RGD

    GO - Biological processi

    1. ganglioside biosynthetic process Source: Ensembl
    2. N-glycan processing Source: Ensembl
    3. sialylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_199227. N-Glycan antennae elongation.
    REACT_213723. Sialic acid metabolism.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2,8-sialyltransferase 8B (EC:2.4.99.-)
    Alternative name(s):
    Sialyltransferase 8B
    Short name:
    SIAT8-B
    Sialyltransferase St8Sia II
    Short name:
    ST8SiaII
    Sialyltransferase X
    Short name:
    STX
    Gene namesi
    Name:St8sia2
    Synonyms:Siat8b, Stx
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621843. St8sia2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: InterPro

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Alpha-2,8-sialyltransferase 8BPRO_0000149288Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi157 ↔ 307By similarity
    Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ07977.
    PRIDEiQ07977.

    PTM databases

    PhosphoSiteiQ07977.

    Expressioni

    Tissue specificityi

    Expressed only in newborn brain.

    Developmental stagei

    Newborn.

    Gene expression databases

    GenevestigatoriQ07977.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016427.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini24 – 375352LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG324948.
    HOGENOMiHOG000232070.
    HOVERGENiHBG056466.
    InParanoidiQ07977.
    KOiK06612.
    PhylomeDBiQ07977.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q07977-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLQFRSWML AALTLLVVFL IFADISEIEE EIGNSGGRGT IRSAVNSLHS    50
    KSNRAEVVIN GSSLPAVADR SNESLKHSIQ PASSKWRHNQ TLSLRIRKQI 100
    LKFLDAEKDI SVLKGTLKPG DIIHYIFDRD STMNVSQNLY ELLPRTSPLK 150
    NKHFQTCAIV GNSGVLLNSG CGQEIDTHSF VIRCNLAPVQ EYARDVGLKT 200
    DLVTMNPSVI QRAFEDLVNA TWREKLLQRL HGLNGSILWI PAFMARGGKE 250
    RVEWVNALIL KHHVNVRTAY PSLRLLHAVR GYWLTNKVHI KRPTTGLLMY 300
    TLATRFCNQI YLYGFWPFPL DQNQNPVKYH YYDSLKYGYT SQASPHTMPL 350
    EFKALKSLHE QGALKLTVGQ CDGAT 375
    Length:375
    Mass (Da):42,400
    Last modified:November 1, 1996 - v1
    Checksum:iF7B3AC1E1E503675
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13445 mRNA. Translation: AAA42147.1.
    PIRiA46727.
    RefSeqiNP_476497.1. NM_057156.1.
    UniGeneiRn.44391.

    Genome annotation databases

    GeneIDi117523.
    KEGGirno:117523.
    UCSCiRGD:621843. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13445 mRNA. Translation: AAA42147.1 .
    PIRi A46727.
    RefSeqi NP_476497.1. NM_057156.1.
    UniGenei Rn.44391.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016427.

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    PTM databases

    PhosphoSitei Q07977.

    Proteomic databases

    PaxDbi Q07977.
    PRIDEi Q07977.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 117523.
    KEGGi rno:117523.
    UCSCi RGD:621843. rat.

    Organism-specific databases

    CTDi 8128.
    RGDi 621843. St8sia2.

    Phylogenomic databases

    eggNOGi NOG324948.
    HOGENOMi HOG000232070.
    HOVERGENi HBG056466.
    InParanoidi Q07977.
    KOi K06612.
    PhylomeDBi Q07977.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_199227. N-Glycan antennae elongation.
    REACT_213723. Sialic acid metabolism.

    Miscellaneous databases

    NextBioi 620309.
    PROi Q07977.

    Gene expression databases

    Genevestigatori Q07977.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Polymerase chain reaction cloning of a developmentally regulated member of the sialyltransferase gene family."
      Livingston B.D., Paulson J.C.
      J. Biol. Chem. 268:11504-11507(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiSIA8B_RAT
    AccessioniPrimary (citable) accession number: Q07977
    Secondary accession number(s): Q64688
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3