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Q07973

- CP24A_HUMAN

UniProt

Q07973 - CP24A_HUMAN

Protein

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Gene

CYP24A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (18 Oct 2001)
      Previous versions | rss
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    Functioni

    Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1-alpha,25-dihydroxyvitamin D3). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.

    Catalytic activityi

    Calcitriol + NADPH + O2 = calcitetrol + NADP+ + H2O.
    Calcidiol + NADPH + O2 = secalciferol + NADP+ + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi462 – 4621Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Source: UniProtKB
    2. 25-hydroxycholecalciferol-24-hydroxylase activity Source: Ensembl
    3. heme binding Source: UniProtKB
    4. iron ion binding Source: InterPro
    5. oxidoreductase activity Source: UniProtKB

    GO - Biological processi

    1. osteoblast differentiation Source: BHF-UCL
    2. oxidation-reduction process Source: UniProtKB
    3. response to vitamin D Source: BHF-UCL
    4. small molecule metabolic process Source: Reactome
    5. steroid metabolic process Source: Reactome
    6. vitamin D catabolic process Source: BHF-UCL
    7. vitamin D metabolic process Source: Reactome
    8. vitamin D receptor signaling pathway Source: BHF-UCL
    9. vitamin metabolic process Source: Reactome
    10. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:HS00395-MONOMER.
    ReactomeiREACT_13450. Vitamins.
    REACT_13523. Vitamin D (calciferol) metabolism.
    SABIO-RKQ07973.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (EC:1.14.13.126)
    Short name:
    24-OHase
    Short name:
    Vitamin D(3) 24-hydroxylase
    Alternative name(s):
    Cytochrome P450 24A1
    Cytochrome P450-CC24
    Gene namesi
    Name:CYP24A1
    Synonyms:CYP24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:2602. CYP24A1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Reactome

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Hypercalcemia infantile (HCAI) [MIM:143880]: A disorder characterized by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti143 – 1431Missing in HCAI; complete loss of function. 1 Publication
    VAR_066408
    Natural varianti159 – 1591R → Q in HCAI; complete loss of function. 1 Publication
    VAR_066409
    Natural varianti322 – 3221E → K in HCAI; complete loss of function. 1 Publication
    VAR_066410
    Natural varianti396 – 3961R → W in HCAI; complete loss of function. 1 Publication
    Corresponds to variant rs114368325 [ dbSNP | Ensembl ].
    VAR_066411
    Natural varianti409 – 4091L → S in HCAI; retains small but measurable levels of activity. 1 Publication
    Corresponds to variant rs6068812 [ dbSNP | Ensembl ].
    VAR_048466

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi143880. phenotype.
    Orphaneti300547. Autosomal recessive infantile hypercalcemia.
    PharmGKBiPA27097.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535MitochondrionBy similarityAdd
    BLAST
    Chaini36 – 5144791,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialPRO_0000003615Add
    BLAST

    Proteomic databases

    MaxQBiQ07973.
    PaxDbiQ07973.
    PRIDEiQ07973.

    PTM databases

    PhosphoSiteiQ07973.

    Expressioni

    Gene expression databases

    ArrayExpressiQ07973.
    BgeeiQ07973.
    CleanExiHS_CYP24A1.
    GenevestigatoriQ07973.

    Organism-specific databases

    HPAiHPA022261.

    Interactioni

    Protein-protein interaction databases

    BioGridi107963. 2 interactions.
    IntActiQ07973. 1 interaction.
    MINTiMINT-6773699.
    STRINGi9606.ENSP00000216862.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07973.
    SMRiQ07973. Positions 51-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000276540.
    HOVERGENiHBG099053.
    InParanoidiQ07973.
    KOiK07436.
    OMAiQHDTLAE.
    OrthoDBiEOG7ZGX4B.
    PhylomeDBiQ07973.
    TreeFamiTF105094.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q07973-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG    50
    ETQNAAALPG PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK 100
    LGSFESVHLG SPCLLEALYR TESAYPQRLE IKPWKAYRDY RKEGYGLLIL 150
    EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN EVLADFMGRI DELCDERGHV 200
    EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM AIKTMMSTFG 250
    RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD 300
    FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ 350
    KLLKEIQSVL PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK 400
    ATVLGEYALP KGTVLMLNTQ VLGSSEDNFE DSSQFRPERW LQEKEKINPF 450
    AHLPFGVGKR MCIGRRLAEL QLHLALCWIV RKYDIQATDN EPVEMLHSGT 500
    LVPSRELPIA FCQR 514
    Length:514
    Mass (Da):58,875
    Last modified:October 18, 2001 - v2
    Checksum:i8862F63771981195
    GO
    Isoform 2 (identifier: Q07973-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         413-478: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:448
    Mass (Da):51,207
    Checksum:i7A4DF62B195B6F9B
    GO
    Isoform 3 (identifier: Q07973-3) [UniParc]FASTAAdd to Basket

    Also known as: CYP24-SV

    The sequence of this isoform differs from the canonical sequence as follows:
         1-8: MSSPISKS → MYSCFSHR
         9-150: Missing.

    Note: Specifically expressed in macrophages. Lacks the transit peptide. May be a dominant negative-acting isoform possibly by sequestering vitamin D metabolites.

    Show »
    Length:372
    Mass (Da):43,051
    Checksum:i943689E132C4FE3B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681G → A in AAA62379. (PubMed:8506296)Curated
    Sequence conflicti68 – 681G → A in AAB03776. (PubMed:8506296)Curated
    Sequence conflicti124 – 1252AY → V in AAA62379. (PubMed:8506296)Curated
    Sequence conflicti270 – 2701D → G in AAA62379. (PubMed:8506296)Curated
    Sequence conflicti365 – 3651V → R in AAA62379. (PubMed:8506296)Curated
    Sequence conflicti368 – 3681A → E in AAA62379. (PubMed:8506296)Curated
    Sequence conflicti390 – 3901S → G in AAA62379. (PubMed:8506296)Curated
    Sequence conflicti511 – 5111F → S in AAB29308. (PubMed:8266831)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti143 – 1431Missing in HCAI; complete loss of function. 1 Publication
    VAR_066408
    Natural varianti157 – 1571R → Q.
    Corresponds to variant rs35051736 [ dbSNP | Ensembl ].
    VAR_048464
    Natural varianti159 – 1591R → Q in HCAI; complete loss of function. 1 Publication
    VAR_066409
    Natural varianti322 – 3221E → K in HCAI; complete loss of function. 1 Publication
    VAR_066410
    Natural varianti374 – 3741M → T.
    Corresponds to variant rs6022990 [ dbSNP | Ensembl ].
    VAR_048465
    Natural varianti396 – 3961R → W in HCAI; complete loss of function. 1 Publication
    Corresponds to variant rs114368325 [ dbSNP | Ensembl ].
    VAR_066411
    Natural varianti409 – 4091L → S in HCAI; retains small but measurable levels of activity. 1 Publication
    Corresponds to variant rs6068812 [ dbSNP | Ensembl ].
    VAR_048466

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 88MSSPISKS → MYSCFSHR in isoform 3. 1 PublicationVSP_053367
    Alternative sequencei9 – 150142Missing in isoform 3. 1 PublicationVSP_053368Add
    BLAST
    Alternative sequencei413 – 47866Missing in isoform 2. 1 PublicationVSP_043101Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13286 mRNA. Translation: AAA62379.1.
    AY858838 mRNA. Translation: AAW50795.1.
    AL138805 Genomic DNA. Translation: CAB91829.1.
    AL138805 Genomic DNA. Translation: CAM27343.1.
    BC109083 mRNA. Translation: AAI09084.1.
    BC109084 mRNA. Translation: AAI09085.1.
    U60669 Genomic DNA. Translation: AAB03776.1. Sequence problems.
    S67623 mRNA. Translation: AAB29308.1.
    CCDSiCCDS33491.1. [Q07973-1]
    CCDS46616.1. [Q07973-2]
    PIRiA47436.
    I55488.
    RefSeqiNP_000773.2. NM_000782.4. [Q07973-1]
    NP_001122387.1. NM_001128915.1. [Q07973-2]
    XP_005260361.1. XM_005260304.2. [Q07973-1]
    UniGeneiHs.89663.

    Genome annotation databases

    EnsembliENST00000216862; ENSP00000216862; ENSG00000019186. [Q07973-1]
    ENST00000395954; ENSP00000379284; ENSG00000019186. [Q07973-3]
    ENST00000395955; ENSP00000379285; ENSG00000019186. [Q07973-2]
    GeneIDi1591.
    KEGGihsa:1591.
    UCSCiuc002xwv.2. human. [Q07973-1]
    uc002xww.2. human. [Q07973-2]

    Polymorphism databases

    DMDMi19862747.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13286 mRNA. Translation: AAA62379.1 .
    AY858838 mRNA. Translation: AAW50795.1 .
    AL138805 Genomic DNA. Translation: CAB91829.1 .
    AL138805 Genomic DNA. Translation: CAM27343.1 .
    BC109083 mRNA. Translation: AAI09084.1 .
    BC109084 mRNA. Translation: AAI09085.1 .
    U60669 Genomic DNA. Translation: AAB03776.1 . Sequence problems.
    S67623 mRNA. Translation: AAB29308.1 .
    CCDSi CCDS33491.1. [Q07973-1 ]
    CCDS46616.1. [Q07973-2 ]
    PIRi A47436.
    I55488.
    RefSeqi NP_000773.2. NM_000782.4. [Q07973-1 ]
    NP_001122387.1. NM_001128915.1. [Q07973-2 ]
    XP_005260361.1. XM_005260304.2. [Q07973-1 ]
    UniGenei Hs.89663.

    3D structure databases

    ProteinModelPortali Q07973.
    SMRi Q07973. Positions 51-514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107963. 2 interactions.
    IntActi Q07973. 1 interaction.
    MINTi MINT-6773699.
    STRINGi 9606.ENSP00000216862.

    Chemistry

    BindingDBi Q07973.
    ChEMBLi CHEMBL4521.
    DrugBanki DB00146. Calcidiol.
    DB00136. Calcitriol.
    DB00169. Cholecalciferol.
    DB00153. Ergocalciferol.
    DB00910. Paricalcitol.

    PTM databases

    PhosphoSitei Q07973.

    Polymorphism databases

    DMDMi 19862747.

    Proteomic databases

    MaxQBi Q07973.
    PaxDbi Q07973.
    PRIDEi Q07973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000216862 ; ENSP00000216862 ; ENSG00000019186 . [Q07973-1 ]
    ENST00000395954 ; ENSP00000379284 ; ENSG00000019186 . [Q07973-3 ]
    ENST00000395955 ; ENSP00000379285 ; ENSG00000019186 . [Q07973-2 ]
    GeneIDi 1591.
    KEGGi hsa:1591.
    UCSCi uc002xwv.2. human. [Q07973-1 ]
    uc002xww.2. human. [Q07973-2 ]

    Organism-specific databases

    CTDi 1591.
    GeneCardsi GC20M052769.
    HGNCi HGNC:2602. CYP24A1.
    HPAi HPA022261.
    MIMi 126065. gene.
    143880. phenotype.
    neXtProti NX_Q07973.
    Orphaneti 300547. Autosomal recessive infantile hypercalcemia.
    PharmGKBi PA27097.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000276540.
    HOVERGENi HBG099053.
    InParanoidi Q07973.
    KOi K07436.
    OMAi QHDTLAE.
    OrthoDBi EOG7ZGX4B.
    PhylomeDBi Q07973.
    TreeFami TF105094.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS00395-MONOMER.
    Reactomei REACT_13450. Vitamins.
    REACT_13523. Vitamin D (calciferol) metabolism.
    SABIO-RK Q07973.

    Miscellaneous databases

    GeneWikii CYP24A1.
    GenomeRNAii 1591.
    NextBioi 6538.
    PROi Q07973.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q07973.
    Bgeei Q07973.
    CleanExi HS_CYP24A1.
    Genevestigatori Q07973.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA."
      Chen K.-S., Prahl J.M., Deluca H.F.
      Proc. Natl. Acad. Sci. U.S.A. 90:4543-4547(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis."
      Ren S., Nguyen L., Wu S., Encinas C., Adams J.S., Hewison M.
      J. Biol. Chem. 280:20604-20611(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements."
      Chen K.-S., DeLuca H.F.
      Biochim. Biophys. Acta 1263:1-9(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-104.
    6. "Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets."
      Labuda M., Lemieux N., Tihy F., Prinster C., Glorieux F.H.
      J. Bone Miner. Res. 8:1397-1406(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 258-514 (ISOFORM 1).
    7. "Metabolism of vitamin D3 by cytochromes P450."
      Sakaki T., Kagawa N., Yamamoto K., Inouye K.
      Front. Biosci. 10:119-134(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBSTRATE SPECIFICITY.
    8. Cited for: VARIANTS HCAI GLU-143 DEL; GLN-159; LYS-322; TRP-396 AND SER-409, CHARACTERIZATION OF VARIANTS HCAI GLU-143 DEL; GLN-159; LYS-322; TRP-396 AND SER-409.

    Entry informationi

    Entry nameiCP24A_HUMAN
    AccessioniPrimary (citable) accession number: Q07973
    Secondary accession number(s): Q15807, Q32ML3, Q5I2W7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 18, 2001
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3