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Q07969

- CD36_RAT

UniProt

Q07969 - CD36_RAT

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Protein
Platelet glycoprotein 4
Gene
Cd36, Fat
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects By similarity. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.1 Publication

GO - Molecular functioni

  1. oleic acid binding Source: RGD
  2. protein binding Source: RGD
  3. thrombospondin receptor activity Source: BHF-UCL
  4. transforming growth factor beta binding Source: BHF-UCL

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cellular response to insulin stimulus Source: RGD
  3. digestive tract development Source: RGD
  4. fatty acid metabolic process Source: RGD
  5. fatty acid oxidation Source: RGD
  6. fatty acid transport Source: RGD
  7. long-chain fatty acid metabolic process Source: RGD
  8. long-chain fatty acid transport Source: RGD
  9. negative regulation of angiogenesis Source: RGD
  10. negative regulation of systemic arterial blood pressure Source: RGD
  11. positive regulation of cytokine secretion Source: RGD
  12. response to activity Source: RGD
  13. response to drug Source: RGD
  14. response to estradiol Source: RGD
  15. response to growth hormone Source: RGD
  16. response to mechanical stimulus Source: RGD
  17. response to nutrient Source: RGD
  18. signal transduction Source: GOC
  19. triglyceride metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein 4
Alternative name(s):
Adipocyte membrane protein
Fatty acid translocase
Fatty acid transport protein
Glycoprotein IIIb
Short name:
GPIIIB
PAS IV
PAS-4
Platelet glycoprotein IV
Short name:
GPIV
CD_antigen: CD36
Gene namesi
Name:Cd36
Synonyms:Fat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2301. Cd36.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 76Cytoplasmic Reviewed prediction
Transmembranei8 – 2922Helical; Reviewed prediction
Add
BLAST
Topological domaini30 – 439410Extracellular Reviewed prediction
Add
BLAST
Transmembranei440 – 46122Helical; Reviewed prediction
Add
BLAST
Topological domaini462 – 47211Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical part of cell Source: RGD
  2. caveola Source: RGD
  3. cell surface Source: BHF-UCL
  4. endoplasmic reticulum Source: RGD
  5. integral component of membrane Source: UniProtKB-KW
  6. intracellular Source: RGD
  7. intracellular membrane-bounded organelle Source: RGD
  8. mitochondrion Source: RGD
  9. plasma membrane Source: RGD
  10. protein complex Source: RGD
  11. sarcolemma Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 472471Platelet glycoprotein 4
PRO_0000144154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteine Inferred
Lipidationi7 – 71S-palmitoyl cysteine Inferred
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi235 – 2351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi243 ↔ 311 By similarity
Glycosylationi247 – 2471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi272 ↔ 333 By similarity
Disulfide bondi313 ↔ 322 By similarity
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi417 – 4171N-linked (GlcNAc...) Reviewed prediction
Lipidationi464 – 4641S-palmitoyl cysteine By similarity
Lipidationi466 – 4661S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ07969.
PRIDEiQ07969.

Expressioni

Tissue specificityi

Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes.

Developmental stagei

Induced during preadipocyte differentiation.

Gene expression databases

GenevestigatoriQ07969.

Interactioni

Subunit structurei

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity By similarity.

Protein-protein interaction databases

MINTiMINT-4997133.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the CD36 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257244.
HOGENOMiHOG000252951.
HOVERGENiHBG002754.
InParanoidiQ07969.
PhylomeDBiQ07969.

Family and domain databases

InterProiIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERiPTHR11923. PTHR11923. 1 hit.
PfamiPF01130. CD36. 1 hit.
[Graphical view]
PRINTSiPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07969-1 [UniParc]FASTAAdd to Basket

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MGCDRNCGLI TGAVIGAVLA VFGGILMPVG DLLIEKTIKR EVVLEEGTIA    50
FKNWVKTGTT VYRQFWIFDV QNPEEVAKNS SKIKVKQRGP YTYRVRYLAK 100
ENITQDPKDS TVSFVQPNGA IFEPSLSVGT ENDNFTVLNL AVAAAPHIYT 150
NSFVQGVLNS LIKKSKSSMF QTRSLKELLW GYKDPFLSLV PYPISTTVGV 200
FYPYNNTVDG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SYCDMINGTD 250
AASFPPFVEK SQTLRFFSSD ICRSIYAVFE SEVNLKGIPV YRFVLPANAF 300
ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS 350
PDVSEPIEGL NPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE 400
ALKNLKRPYI VPILWLNETG TIGDEKAEMF RNQVTGKIKL LGLVEMVLLG 450
VGVVMFVAFM ISYCACRSKN GK 472
Length:472
Mass (Da):52,731
Last modified:May 1, 2007 - v3
Checksum:i69F9513B1B85CBF0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671I → V in AAA02878. 1 Publication
Sequence conflicti86 – 861K → I in AAA02878. 1 Publication
Sequence conflicti215 – 2151F → S in AAA02878. 1 Publication
Sequence conflicti257 – 2582FV → LG in AAA02878. 1 Publication
Sequence conflicti262 – 2621Q → R in AAA02878. 1 Publication
Sequence conflicti341 – 3411I → N in AAA02878. 1 Publication
Sequence conflicti363 – 3631N → T in AAA02878. 1 Publication
Sequence conflicti384 – 3841A → S in AAA02878. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19658 mRNA. Translation: AAA02878.1.
AF072411 mRNA. Translation: AAC24876.1.
AF113914 mRNA. Translation: AAF25552.1.
PIRiA47402.
UniGeneiRn.102418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19658 mRNA. Translation: AAA02878.1 .
AF072411 mRNA. Translation: AAC24876.1 .
AF113914 mRNA. Translation: AAF25552.1 .
PIRi A47402.
UniGenei Rn.102418.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997133.

Chemistry

ChEMBLi CHEMBL2163174.

Proteomic databases

PaxDbi Q07969.
PRIDEi Q07969.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2301. Cd36.

Phylogenomic databases

eggNOGi NOG257244.
HOGENOMi HOG000252951.
HOVERGENi HBG002754.
InParanoidi Q07969.
PhylomeDBi Q07969.

Gene expression databases

Genevestigatori Q07969.

Family and domain databases

InterProi IPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view ]
PANTHERi PTHR11923. PTHR11923. 1 hit.
Pfami PF01130. CD36. 1 hit.
[Graphical view ]
PRINTSi PR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNeti Search...

Publicationsi

  1. "Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36."
    Abumrad N.A., El-Maghrabi M.R., Amri E.-Z., Lopez E., Grimaldi P.A.
    J. Biol. Chem. 268:17665-17668(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adipocyte.
  2. "Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes."
    Guthmann F., Haupt R., Looman A.C., Spener F., Ruestow B.
    Am. J. Physiol. 277:L191-L196(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  3. "Potential allele of rat CD36 antigen."
    Zhang X., Mayrhofer G., Ey P.L.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dark agouti.
  4. "Purification of the major substrate for palmitoylation in rat adipocytes: N-terminal homology with CD36 and evidence for cell surface acylation."
    Jochen A., Hays J.
    J. Lipid Res. 34:1783-1792(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-31, PALMITOYLATION AT CYS-3 AND CYS-7.
    Tissue: Adipocyte.
  5. "Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids."
    Harmon C.M., Abumrad N.A.
    J. Membr. Biol. 133:43-49(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16, FUNCTION.
    Strain: Sprague-Dawley.
    Tissue: Adipocyte.

Entry informationi

Entry nameiCD36_RAT
AccessioniPrimary (citable) accession number: Q07969
Secondary accession number(s): Q925W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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