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Reviewed, UniProtKB/Swiss-Prot Q07969 (CD36_RAT)

Last modified June 16, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Platelet glycoprotein 4
Alternative name(s):
    Platelet glycoprotein IV
      Short name=GPIV
    GPIIIB
    PAS IV
    PAS-4
    Fatty acid transport protein
    Fatty acid translocase
    Adipocyte membrane protein
    CD_antigen=CD36
Gene names
Name: Cd36
Synonyms: Fat
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length472 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes.

Developmental stage

Induced during preadipocyte differentiation.

Sequence similarities

Belongs to the CD36 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4 Ref.5
Chain2 – 472471Platelet glycoprotein 4
PRO_0000144154

Regions

Topological domain2 – 76Cytoplasmic Potential
Transmembrane8 – 2922 Potential
Topological domain30 – 439410Extracellular Potential
Transmembrane440 – 46122 Potential
Topological domain462 – 47211Cytoplasmic Potential

Amino acid modifications

Lipidation31S-palmitoyl cysteine Probable
Lipidation71S-palmitoyl cysteine Probable
Lipidation4641S-palmitoyl cysteine By similarity
Lipidation4661S-palmitoyl cysteine By similarity
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2051N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation3211N-linked (GlcNAc...) Potential
Glycosylation4171N-linked (GlcNAc...) Potential
Disulfide bond243 ↔ 311 By similarity
Disulfide bond272 ↔ 333 By similarity
Disulfide bond313 ↔ 322 By similarity

Experimental info

Sequence conflict671I → V in AAA02878. Ref.1
Sequence conflict861K → I in AAA02878. Ref.1
Sequence conflict2151F → S in AAA02878. Ref.1
Sequence conflict257 – 2582FV → LG in AAA02878. Ref.1
Sequence conflict2621Q → R in AAA02878. Ref.1
Sequence conflict3411I → N in AAA02878. Ref.1
Sequence conflict3631N → T in AAA02878. Ref.1
Sequence conflict3841A → S in AAA02878. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q07969-1 [UniParc].

Last modified May 1, 2007. Version 3.
Checksum: 69F9513B1B85CBF0

FASTA47252,731
        10         20         30         40         50         60 
MGCDRNCGLI TGAVIGAVLA VFGGILMPVG DLLIEKTIKR EVVLEEGTIA FKNWVKTGTT 

        70         80         90        100        110        120 
VYRQFWIFDV QNPEEVAKNS SKIKVKQRGP YTYRVRYLAK ENITQDPKDS TVSFVQPNGA 

       130        140        150        160        170        180 
IFEPSLSVGT ENDNFTVLNL AVAAAPHIYT NSFVQGVLNS LIKKSKSSMF QTRSLKELLW 

       190        200        210        220        230        240 
GYKDPFLSLV PYPISTTVGV FYPYNNTVDG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE 

       250        260        270        280        290        300 
SYCDMINGTD AASFPPFVEK SQTLRFFSSD ICRSIYAVFE SEVNLKGIPV YRFVLPANAF 

       310        320        330        340        350        360 
ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS PDVSEPIEGL 

       370        380        390        400        410        420 
NPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE ALKNLKRPYI VPILWLNETG 

       430        440        450        460        470 
TIGDEKAEMF RNQVTGKIKL LGLVEMVLLG VGVVMFVAFM ISYCACRSKN GK

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References

[1]"Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36."
Abumrad N.A., El-Maghrabi M.R., Amri E.-Z., Lopez E., Grimaldi P.A.
J. Biol. Chem. 268:17665-17668(1993) [PubMed: 7688729] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Adipocyte.
[2]"Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes."
Guthmann F., Haupt R., Looman A.C., Spener F., Ruestow B.
Am. J. Physiol. 277:L191-L196(1999) [PubMed: 10409247] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
[3]"Potential allele of rat CD36 antigen."
Zhang X., Mayrhofer G., Ey P.L.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Dark agouti.
[4]"Purification of the major substrate for palmitoylation in rat adipocytes: N-terminal homology with CD36 and evidence for cell surface acylation."
Jochen A., Hays J.
J. Lipid Res. 34:1783-1792(1993) [PubMed: 7504047] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-31, PALMITOYLATION AT CYS-3 AND CYS-7.
Tissue: Adipocyte.
[5]"Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids."
Harmon C.M., Abumrad N.A.
J. Membr. Biol. 133:43-49(1993) [PubMed: 8320718] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-16.
Strain: Sprague-Dawley.
Tissue: Adipocyte.

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Cross-references

Sequence databases

L19658 mRNA. Translation: AAA02878.1.
AF072411 mRNA. Translation: AAC24876.1.
AF113914 mRNA. Translation: AAF25552.1.
IPIIPI00231197.
PIRA47402.
UniGeneRn.102418
Rn.205840

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ07969.

Genome annotation databases

EnsemblENSRNOG00000005906. Rattus norvegicus. [Contig view]

Organism-specific databases

RGD2301. Cd36.

Phylogenomic databases

HOVERGENQ07969.

Gene expression databases

ArrayExpressQ07969.
GermOnlineENSRNOG00000005906. Rattus norvegicus.

Family and domain databases

InterProIPR002159. CD36.
IPR005428. CD36_antigen.
[Graphical view]
PANTHERPTHR11923. CD36. 1 hit.
PfamPF01130. CD36. 1 hit.
[Graphical view]
PRINTSPR01610. CD36ANTIGEN.
PR01609. CD36FAMILY.
ProtoNetSearch...

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Entry information

Entry nameCD36_RAT
AccessionPrimary (citable) accession number: Q07969
Secondary accession number(s): Q925W0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: May 1, 2007
Last modified: June 16, 2009
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents