Reviewed, UniProtKB/Swiss-Prot Q07969 (CD36_RAT)

Names and origin

Protein names

Recommended name:
    Platelet glycoprotein 4
Alternative name(s):
    Platelet glycoprotein IV
      Short name=GPIV
    GPIIIB
    PAS IV
    PAS-4
    Fatty acid transport protein
    Fatty acid translocase
    Adipocyte membrane protein
    CD_antigen=CD36

Gene names

Name:	Cd36
Synonyms:	Fat

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes.
Developmental stage	Induced during preadipocyte differentiation.
Sequence similarities	Belongs to the CD36 family.

Ontologies

Keywords
Biological process	Cell adhesion Transport
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Receptor
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 472	471	Platelet glycoprotein 4
Regions
	Topological domain	2 – 7	6	Cytoplasmic Potential
	Transmembrane	8 – 29	22	Potential
	Topological domain	30 – 439	410	Extracellular Potential
	Transmembrane	440 – 461	22	Potential
	Topological domain	462 – 472	11	Cytoplasmic Potential
Amino acid modifications
	Lipidation	3	1	S-palmitoyl cysteine Probable
	Lipidation	7	1	S-palmitoyl cysteine Probable
	Lipidation	464	1	S-palmitoyl cysteine By similarity
	Lipidation	466	1	S-palmitoyl cysteine By similarity
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	102	1	N-linked (GlcNAc...) Potential
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Glycosylation	205	1	N-linked (GlcNAc...) Potential
	Glycosylation	220	1	N-linked (GlcNAc...) Potential
	Glycosylation	235	1	N-linked (GlcNAc...) Potential
	Glycosylation	247	1	N-linked (GlcNAc...) Potential
	Glycosylation	321	1	N-linked (GlcNAc...) Potential
	Glycosylation	417	1	N-linked (GlcNAc...) Potential
	Disulfide bond	243 ↔ 311		By similarity
	Disulfide bond	272 ↔ 333		By similarity
	Disulfide bond	313 ↔ 322		By similarity
Experimental info
	Sequence conflict	67	1	I → V in AAA02878. Ref.1
	Sequence conflict	86	1	K → I in AAA02878. Ref.1
	Sequence conflict	215	1	F → S in AAA02878. Ref.1
	Sequence conflict	257 – 258	2	FV → LG in AAA02878. Ref.1
	Sequence conflict	262	1	Q → R in AAA02878. Ref.1
	Sequence conflict	341	1	I → N in AAA02878. Ref.1
	Sequence conflict	363	1	N → T in AAA02878. Ref.1
	Sequence conflict	384	1	A → S in AAA02878. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q07969-1 [UniParc]. Last modified May 1, 2007. Version 3. Checksum: 69F9513B1B85CBF0	FASTA	472	52,731
	10 20 30 40 50 60 MGCDRNCGLI TGAVIGAVLA VFGGILMPVG DLLIEKTIKR EVVLEEGTIA FKNWVKTGTT 70 80 90 100 110 120 VYRQFWIFDV QNPEEVAKNS SKIKVKQRGP YTYRVRYLAK ENITQDPKDS TVSFVQPNGA 130 140 150 160 170 180 IFEPSLSVGT ENDNFTVLNL AVAAAPHIYT NSFVQGVLNS LIKKSKSSMF QTRSLKELLW 190 200 210 220 230 240 GYKDPFLSLV PYPISTTVGV FYPYNNTVDG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE 250 260 270 280 290 300 SYCDMINGTD AASFPPFVEK SQTLRFFSSD ICRSIYAVFE SEVNLKGIPV YRFVLPANAF 310 320 330 340 350 360 ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS PDVSEPIEGL 370 380 390 400 410 420 NPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE ALKNLKRPYI VPILWLNETG 430 440 450 460 470 TIGDEKAEMF RNQVTGKIKL LGLVEMVLLG VGVVMFVAFM ISYCACRSKN GK

References

[1]	"Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36." Abumrad N.A., El-Maghrabi M.R., Amri E.-Z., Lopez E., Grimaldi P.A. J. Biol. Chem. 268:17665-17668(1993) [PubMed: 7688729] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adipocyte.
[2]	"Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes." Guthmann F., Haupt R., Looman A.C., Spener F., Ruestow B. Am. J. Physiol. 277:L191-L196(1999) [PubMed: 10409247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar.
[3]	"Potential allele of rat CD36 antigen." Zhang X., Mayrhofer G., Ey P.L. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Dark agouti.
[4]	"Purification of the major substrate for palmitoylation in rat adipocytes: N-terminal homology with CD36 and evidence for cell surface acylation." Jochen A., Hays J. J. Lipid Res. 34:1783-1792(1993) [PubMed: 7504047] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-31, PALMITOYLATION AT CYS-3 AND CYS-7. Tissue: Adipocyte.
[5]	"Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids." Harmon C.M., Abumrad N.A. J. Membr. Biol. 133:43-49(1993) [PubMed: 8320718] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-16. Strain: Sprague-Dawley. Tissue: Adipocyte.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L19658 mRNA. Translation: AAA02878.1. AF072411 mRNA. Translation: AAC24876.1. AF113914 mRNA. Translation: AAF25552.1.
PIR	A47402.
UniGene	Rn.102418 Rn.205840 Rn.211898
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000005906. Rattus norvegicus. [Contig view]
Organism-specific databases
RGD	2301. Cd36.
Phylogenomic databases
HOVERGEN	Q07969.
Gene expression databases
ArrayExpress	Q07969.
GermOnline	ENSRNOG00000005906. Rattus norvegicus.
Family and domain databases
InterPro	IPR002159. CD36. IPR005428. CD36_antigen. [Graphical view]
PANTHER	PTHR11923. CD36. 1 hit.
Pfam	PF01130. CD36. 1 hit. [Graphical view]
PRINTS	PR01610. CD36ANTIGEN. PR01609. CD36FAMILY.
ProDom	Q07969. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CD36_RAT

Accession

Primary (citable) accession number: Q07969
Secondary accession number(s): Q925W0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	May 1, 2007
Last modified:	July 22, 2008
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)