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Q07969

- CD36_RAT

UniProt

Q07969 - CD36_RAT

Protein

Platelet glycoprotein 4

Gene

Cd36

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (01 May 2007)
      Previous versions | rss
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    Functioni

    Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects By similarity. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.By similarity1 Publication

    GO - Molecular functioni

    1. oleic acid binding Source: RGD
    2. protein binding Source: RGD
    3. thrombospondin receptor activity Source: BHF-UCL
    4. transforming growth factor beta binding Source: BHF-UCL

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cellular response to insulin stimulus Source: RGD
    3. digestive tract development Source: RGD
    4. fatty acid metabolic process Source: RGD
    5. fatty acid oxidation Source: RGD
    6. fatty acid transport Source: RGD
    7. long-chain fatty acid metabolic process Source: RGD
    8. long-chain fatty acid transport Source: RGD
    9. negative regulation of angiogenesis Source: RGD
    10. negative regulation of systemic arterial blood pressure Source: RGD
    11. positive regulation of cytokine secretion Source: RGD
    12. response to activity Source: RGD
    13. response to drug Source: RGD
    14. response to estradiol Source: RGD
    15. response to growth hormone Source: RGD
    16. response to mechanical stimulus Source: RGD
    17. response to nutrient Source: RGD
    18. signal transduction Source: GOC
    19. triglyceride metabolic process Source: RGD

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet glycoprotein 4
    Alternative name(s):
    Adipocyte membrane protein
    Fatty acid translocase
    Fatty acid transport protein
    Glycoprotein IIIb
    Short name:
    GPIIIB
    PAS IV
    PAS-4
    Platelet glycoprotein IV
    Short name:
    GPIV
    CD_antigen: CD36
    Gene namesi
    Name:Cd36
    Synonyms:Fat
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2301. Cd36.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: RGD
    2. caveola Source: RGD
    3. cell surface Source: BHF-UCL
    4. endoplasmic reticulum Source: RGD
    5. integral component of membrane Source: UniProtKB-KW
    6. intracellular Source: RGD
    7. intracellular membrane-bounded organelle Source: RGD
    8. mitochondrion Source: RGD
    9. plasma membrane Source: RGD
    10. protein complex Source: RGD
    11. sarcolemma Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 472471Platelet glycoprotein 4PRO_0000144154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi3 – 31S-palmitoyl cysteine1 Publication
    Lipidationi7 – 71S-palmitoyl cysteine1 Publication
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi243 ↔ 311By similarity
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi272 ↔ 333By similarity
    Disulfide bondi313 ↔ 322By similarity
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
    Lipidationi464 – 4641S-palmitoyl cysteineBy similarity
    Lipidationi466 – 4661S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ07969.
    PRIDEiQ07969.

    Expressioni

    Tissue specificityi

    Predominant in heart, intestine, spleen, fat, skeletal muscle, lower in testes.

    Developmental stagei

    Induced during preadipocyte differentiation.

    Gene expression databases

    GenevestigatoriQ07969.

    Interactioni

    Subunit structurei

    Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.By similarity

    Protein-protein interaction databases

    MINTiMINT-4997133.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 76CytoplasmicSequence Analysis
    Topological domaini30 – 439410ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini462 – 47211CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei440 – 46122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 12028Required for interaction with thrombospondins, THBS1 and THBS2By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CD36 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257244.
    HOGENOMiHOG000252951.
    HOVERGENiHBG002754.
    InParanoidiQ07969.
    PhylomeDBiQ07969.

    Family and domain databases

    InterProiIPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view]
    PANTHERiPTHR11923. PTHR11923. 1 hit.
    PfamiPF01130. CD36. 1 hit.
    [Graphical view]
    PRINTSiPR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q07969-1 [UniParc]FASTAAdd to Basket

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    MGCDRNCGLI TGAVIGAVLA VFGGILMPVG DLLIEKTIKR EVVLEEGTIA    50
    FKNWVKTGTT VYRQFWIFDV QNPEEVAKNS SKIKVKQRGP YTYRVRYLAK 100
    ENITQDPKDS TVSFVQPNGA IFEPSLSVGT ENDNFTVLNL AVAAAPHIYT 150
    NSFVQGVLNS LIKKSKSSMF QTRSLKELLW GYKDPFLSLV PYPISTTVGV 200
    FYPYNNTVDG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SYCDMINGTD 250
    AASFPPFVEK SQTLRFFSSD ICRSIYAVFE SEVNLKGIPV YRFVLPANAF 300
    ASPLQNPDNH CFCTEKVISN NCTSYGVLDI GKCKEGKPVY ISLPHFLHAS 350
    PDVSEPIEGL NPNEDEHRTY LDVEPITGFT LQFAKRLQVN ILVKPARKIE 400
    ALKNLKRPYI VPILWLNETG TIGDEKAEMF RNQVTGKIKL LGLVEMVLLG 450
    VGVVMFVAFM ISYCACRSKN GK 472
    Length:472
    Mass (Da):52,731
    Last modified:May 1, 2007 - v3
    Checksum:i69F9513B1B85CBF0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671I → V in AAA02878. (PubMed:7688729)Curated
    Sequence conflicti86 – 861K → I in AAA02878. (PubMed:7688729)Curated
    Sequence conflicti215 – 2151F → S in AAA02878. (PubMed:7688729)Curated
    Sequence conflicti257 – 2582FV → LG in AAA02878. (PubMed:7688729)Curated
    Sequence conflicti262 – 2621Q → R in AAA02878. (PubMed:7688729)Curated
    Sequence conflicti341 – 3411I → N in AAA02878. (PubMed:7688729)Curated
    Sequence conflicti363 – 3631N → T in AAA02878. (PubMed:7688729)Curated
    Sequence conflicti384 – 3841A → S in AAA02878. (PubMed:7688729)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19658 mRNA. Translation: AAA02878.1.
    AF072411 mRNA. Translation: AAC24876.1.
    AF113914 mRNA. Translation: AAF25552.1.
    PIRiA47402.
    UniGeneiRn.102418.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L19658 mRNA. Translation: AAA02878.1 .
    AF072411 mRNA. Translation: AAC24876.1 .
    AF113914 mRNA. Translation: AAF25552.1 .
    PIRi A47402.
    UniGenei Rn.102418.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997133.

    Chemistry

    ChEMBLi CHEMBL2163174.

    Proteomic databases

    PaxDbi Q07969.
    PRIDEi Q07969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2301. Cd36.

    Phylogenomic databases

    eggNOGi NOG257244.
    HOGENOMi HOG000252951.
    HOVERGENi HBG002754.
    InParanoidi Q07969.
    PhylomeDBi Q07969.

    Gene expression databases

    Genevestigatori Q07969.

    Family and domain databases

    InterProi IPR002159. CD36.
    IPR005428. CD36_antigen.
    [Graphical view ]
    PANTHERi PTHR11923. PTHR11923. 1 hit.
    Pfami PF01130. CD36. 1 hit.
    [Graphical view ]
    PRINTSi PR01610. CD36ANTIGEN.
    PR01609. CD36FAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36."
      Abumrad N.A., El-Maghrabi M.R., Amri E.-Z., Lopez E., Grimaldi P.A.
      J. Biol. Chem. 268:17665-17668(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adipocyte.
    2. "Fatty acid translocase/CD36 mediates the uptake of palmitate by type II pneumocytes."
      Guthmann F., Haupt R., Looman A.C., Spener F., Ruestow B.
      Am. J. Physiol. 277:L191-L196(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
    3. "Potential allele of rat CD36 antigen."
      Zhang X., Mayrhofer G., Ey P.L.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Dark agouti.
    4. "Purification of the major substrate for palmitoylation in rat adipocytes: N-terminal homology with CD36 and evidence for cell surface acylation."
      Jochen A., Hays J.
      J. Lipid Res. 34:1783-1792(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-31, PALMITOYLATION AT CYS-3 AND CYS-7.
      Tissue: Adipocyte.
    5. "Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids."
      Harmon C.M., Abumrad N.A.
      J. Membr. Biol. 133:43-49(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-16, FUNCTION.
      Strain: Sprague-Dawley.
      Tissue: Adipocyte.

    Entry informationi

    Entry nameiCD36_RAT
    AccessioniPrimary (citable) accession number: Q07969
    Secondary accession number(s): Q925W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3