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Protein

Coagulation factor XIII B chain

Gene

F13b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-MMU-140875. Common Pathway of Fibrin Clot Formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII B chain
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase B chain
Transglutaminase B chain
Gene namesi
Name:F13b
Synonyms:Cf13b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88379. F13b.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 669648Coagulation factor XIII B chainPRO_0000021223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 77PROSITE-ProRule annotation
Disulfide bondi60 ↔ 88PROSITE-ProRule annotation
Disulfide bondi92 ↔ 136PROSITE-ProRule annotation
Disulfide bondi119 ↔ 147PROSITE-ProRule annotation
Disulfide bondi154 ↔ 198PROSITE-ProRule annotation
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Disulfide bondi181 ↔ 209PROSITE-ProRule annotation
Disulfide bondi214 ↔ 256PROSITE-ProRule annotation
Disulfide bondi242 ↔ 268PROSITE-ProRule annotation
Disulfide bondi275 ↔ 317PROSITE-ProRule annotation
Disulfide bondi303 ↔ 328PROSITE-ProRule annotation
Disulfide bondi337 ↔ 379PROSITE-ProRule annotation
Disulfide bondi365 ↔ 390PROSITE-ProRule annotation
Disulfide bondi397 ↔ 440PROSITE-ProRule annotation
Disulfide bondi426 ↔ 451PROSITE-ProRule annotation
Disulfide bondi455 ↔ 506PROSITE-ProRule annotation
Disulfide bondi487 ↔ 516PROSITE-ProRule annotation
Disulfide bondi525 ↔ 568PROSITE-ProRule annotation
Glycosylationi546 – 5461N-linked (GlcNAc...)2 Publications
Disulfide bondi554 ↔ 579PROSITE-ProRule annotation
Disulfide bondi583 ↔ 637PROSITE-ProRule annotation
Disulfide bondi617 ↔ 647PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ07968.
PaxDbiQ07968.
PeptideAtlasiQ07968.
PRIDEiQ07968.

PTM databases

iPTMnetiQ07968.
PhosphoSiteiQ07968.

Expressioni

Tissue specificityi

Predominantly expressed in liver and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000026368.
CleanExiMM_F13B.
GenevisibleiQ07968. MM.

Interactioni

Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.By similarity

Protein-protein interaction databases

BioGridi199567. 1 interaction.
IntActiQ07968. 1 interaction.
STRINGi10090.ENSMUSP00000027615.

Structurei

3D structure databases

ProteinModelPortaliQ07968.
SMRiQ07968. Positions 24-656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 8965Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini90 – 14960Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini152 – 21160Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini212 – 27059Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini273 – 33058Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini335 – 39258Sushi 6PROSITE-ProRule annotationAdd
BLAST
Domaini395 – 45359Sushi 7PROSITE-ProRule annotationAdd
BLAST
Domaini454 – 51764Sushi 8PROSITE-ProRule annotationAdd
BLAST
Domaini523 – 58159Sushi 9PROSITE-ProRule annotationAdd
BLAST
Domaini582 – 64867Sushi 10PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IE82. Eukaryota.
ENOG410YE48. LUCA.
GeneTreeiENSGT00840000129714.
HOGENOMiHOG000049250.
HOVERGENiHBG005626.
InParanoidiQ07968.
KOiK03906.
OMAiPLCTRKE.
OrthoDBiEOG091G03MW.
PhylomeDBiQ07968.
TreeFamiTF326157.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 8 hits.
[Graphical view]
SMARTiSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 10 hits.
PROSITEiPS50923. SUSHI. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q07968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTLRHLPFI LLLILSGELY AEEKQCDFPT VENGRIAQYY YTFKSFYFPM
60 70 80 90 100
SVDKKLSFFC LAGYATESGK QEEQIRCTAE GWSPNPRCYK KCLKPDLRNG
110 120 130 140 150
YVSNDKVLYK LQERMSYGCS SGYKTTGGKD EEVVHCLSAG WSSQPSCRKE
160 170 180 190 200
QETCLAPELE HGNYSTTQRT FKVKDIVAYT CTAGYYTTTG KQTGEAECQA
210 220 230 240 250
NGWSLTPQCN KLMCSSLRLI ENGYFHPVKQ TYEEGDVVQF FCHENYYLSG
260 270 280 290 300
SDLIQCYNFG WYPESPICEG RRNRCPPPPV PLNSKIQPHS TTYRHGERVH
310 320 330 340 350
IECELNFVIQ GSEELLCENG KWTEPPKCIE EKEKVACEQP PSVENGVAHP
360 370 380 390 400
HSEIYYSGDK VTYRCGGGYS LRGSSTITCN RGRWTLPPEC VENIENCKPP
410 420 430 440 450
PDIANGVVVD GLLASYTTGS SVEYRCNEYY LLKGSETSRC EQGAWSSPPV
460 470 480 490 500
CLEPCTIDVD HMNRNNIQLK WKYEGKILHG DLIDFVCKQG YNLSPSIPLS
510 520 530 540 550
EISAQCNRGD VRYPMCIRKE SKGMCASPPV IRNGDIVSSA ARTYENGSSV
560 570 580 590 600
EYRCFDNHFL QGSQNVYCVD GVWTTPPSCL EPCTLSFVEM DKNYLQLKWN
610 620 630 640 650
FDNRPLILHG EYIEFMCKRD AYISETSIAG SVLRVQCDRG RLKYPKCTPR
660
DRRLSFQEAL RTRRQMEKR
Length:669
Mass (Da):76,195
Last modified:October 3, 2012 - v2
Checksum:i1ADB8DCCDE1050E0
GO

Sequence cautioni

The sequence BAA00963 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371V → L in BAA00963 (PubMed:8468048).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10071 mRNA. Translation: BAA00963.1. Different initiation.
AL837518, AC158946 Genomic DNA. Translation: CAM20501.1.
CH466520 Genomic DNA. Translation: EDL39526.1.
CCDSiCCDS48386.1.
PIRiA46013.
RefSeqiNP_112441.2. NM_031164.2.
UniGeneiMm.30105.

Genome annotation databases

EnsembliENSMUST00000027615; ENSMUSP00000027615; ENSMUSG00000026368.
GeneIDi14060.
KEGGimmu:14060.
UCSCiuc007cwk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10071 mRNA. Translation: BAA00963.1. Different initiation.
AL837518, AC158946 Genomic DNA. Translation: CAM20501.1.
CH466520 Genomic DNA. Translation: EDL39526.1.
CCDSiCCDS48386.1.
PIRiA46013.
RefSeqiNP_112441.2. NM_031164.2.
UniGeneiMm.30105.

3D structure databases

ProteinModelPortaliQ07968.
SMRiQ07968. Positions 24-656.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199567. 1 interaction.
IntActiQ07968. 1 interaction.
STRINGi10090.ENSMUSP00000027615.

PTM databases

iPTMnetiQ07968.
PhosphoSiteiQ07968.

Proteomic databases

MaxQBiQ07968.
PaxDbiQ07968.
PeptideAtlasiQ07968.
PRIDEiQ07968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027615; ENSMUSP00000027615; ENSMUSG00000026368.
GeneIDi14060.
KEGGimmu:14060.
UCSCiuc007cwk.2. mouse.

Organism-specific databases

CTDi2165.
MGIiMGI:88379. F13b.

Phylogenomic databases

eggNOGiENOG410IE82. Eukaryota.
ENOG410YE48. LUCA.
GeneTreeiENSGT00840000129714.
HOGENOMiHOG000049250.
HOVERGENiHBG005626.
InParanoidiQ07968.
KOiK03906.
OMAiPLCTRKE.
OrthoDBiEOG091G03MW.
PhylomeDBiQ07968.
TreeFamiTF326157.

Enzyme and pathway databases

ReactomeiR-MMU-140875. Common Pathway of Fibrin Clot Formation.

Miscellaneous databases

PROiQ07968.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026368.
CleanExiMM_F13B.
GenevisibleiQ07968. MM.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 8 hits.
[Graphical view]
SMARTiSM00032. CCP. 8 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 10 hits.
PROSITEiPS50923. SUSHI. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF13B_MOUSE
AccessioniPrimary (citable) accession number: Q07968
Secondary accession number(s): B1AY02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.