ID ABDA_TRICA Reviewed; 343 AA. AC Q07961; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1999, sequence version 2. DT 27-MAR-2024, entry version 118. DE RecName: Full=Homeobox protein abdominal-A homolog; GN Name=ABD-A; OS Tribolium castaneum (Red flour beetle). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium. OX NCBI_TaxID=7070; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. RC STRAIN=Georgia; RA Brown S.; RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-343. RX PubMed=7900986; DOI=10.1242/dev.117.1.233; RA Stuart J.J., Brown S.J., Beeman R.W., Denell R.E.; RT "The Tribolium homeotic gene Abdominal is homologous to abdominal-A of the RT Drosophila bithorax complex."; RL Development 117:233-243(1993). CC -!- FUNCTION: Sequence-specific transcription factor which is part of a CC developmental regulatory system that provides cells with specific CC positional identities on the anterior-posterior axis. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Abd-AII; CC IsoId=Q07961-1; Sequence=Displayed; CC Name=Abd-AI; CC IsoId=Q07961-2; Sequence=VSP_002395; CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF017415; AAB70262.1; -; mRNA. DR EMBL; AF017415; AAB70263.1; -; mRNA. DR EMBL; AF017414; AAB70261.1; -; Genomic_DNA. DR EMBL; AF017414; AAB70260.1; -; Genomic_DNA. DR EMBL; X72339; CAA51066.1; -; Genomic_DNA. DR RefSeq; NP_001034518.1; NM_001039429.1. [Q07961-1] DR RefSeq; XP_015839429.1; XM_015983943.1. [Q07961-1] DR AlphaFoldDB; Q07961; -. DR SMR; Q07961; -. DR EnsemblMetazoa; TC000894_001; TC000894_001; TC000894. [Q07961-1] DR GeneID; 641595; -. DR KEGG; tca:641595; -. DR CTD; 42037; -. DR eggNOG; KOG0489; Eukaryota. DR HOGENOM; CLU_750519_0_0_1; -. DR OMA; MSHEQHK; -. DR PhylomeDB; Q07961; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR CDD; cd00086; homeodomain; 1. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR022132; Abdominal-A. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR020479; Homeobox_metazoa. DR PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1. DR PANTHER; PTHR45659:SF4; HOMEOTIC PROTEIN ULTRABITHORAX; 1. DR Pfam; PF12407; Abdominal-A; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00024; HOMEOBOX. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Developmental protein; DNA-binding; Homeobox; KW Nucleus. FT CHAIN 1..343 FT /note="Homeobox protein abdominal-A homolog" FT /id="PRO_0000200254" FT DNA_BIND 216..275 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 29..54 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 286..343 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 286..302 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 311..326 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 1..59 FT /note="Missing (in isoform Abd-AI)" FT /evidence="ECO:0000305" FT /id="VSP_002395" SQ SEQUENCE 343 AA; 37772 MW; D5CE73A71CFECE48 CRC64; MSSKFIIDSM LPKYHQQFHH QQLFQSATTE APAAYSSSSP SGSSPQHSSS SASTSPAARM YPYVSAAHHH HQAAAAAFGA AASGSMVPSF SSTASSALAA AVDAATDKSC RYTAGLAANV TPADSMVNYT LGQHHHNGAA VSAASSVSAA SASMAVAAQF YHQAASAVVD PLNSCSQPAA PGGQPIPDIP RYPWMSITDW MSPFDRVVCG PNGCPRRRGR QTYTRFQTLE LEKEFHFNHY LTRRRRIEIA HALCLTERQI KIWFQNRRMK LKKELRAVKE INEQARRERE EQERHKQQQQ EKQQKIEQQT HSSIHQHHHD PMKMSLDKSG GSDLLKAVSK VPT //