Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein abdominal-A homolog

Gene

ABD-A

Organism
Tribolium castaneum (Red flour beetle)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi216 – 27560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein abdominal-A homolog
Gene namesi
Name:ABD-A
OrganismiTribolium castaneum (Red flour beetle)
Taxonomic identifieri7070 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Homeobox protein abdominal-A homologPRO_0000200254Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ07961.
SMRiQ07961. Positions 216-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 449Poly-Ser
Compositional biasi48 – 558Poly-Ser
Compositional biasi68 – 714Poly-His
Compositional biasi73 – 775Poly-Ala
Compositional biasi243 – 2464Poly-Arg
Compositional biasi297 – 3004Poly-Gln

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG328968.
KOiK09311.
OMAiTIQACTT.
PhylomeDBiQ07961.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022132. Abdominal-A.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12407. Abdominal-A. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Abd-AII (identifier: Q07961-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKFIIDSM LPKYHQQFHH QQLFQSATTE APAAYSSSSP SGSSPQHSSS
60 70 80 90 100
SASTSPAARM YPYVSAAHHH HQAAAAAFGA AASGSMVPSF SSTASSALAA
110 120 130 140 150
AVDAATDKSC RYTAGLAANV TPADSMVNYT LGQHHHNGAA VSAASSVSAA
160 170 180 190 200
SASMAVAAQF YHQAASAVVD PLNSCSQPAA PGGQPIPDIP RYPWMSITDW
210 220 230 240 250
MSPFDRVVCG PNGCPRRRGR QTYTRFQTLE LEKEFHFNHY LTRRRRIEIA
260 270 280 290 300
HALCLTERQI KIWFQNRRMK LKKELRAVKE INEQARRERE EQERHKQQQQ
310 320 330 340
EKQQKIEQQT HSSIHQHHHD PMKMSLDKSG GSDLLKAVSK VPT
Length:343
Mass (Da):37,772
Last modified:July 15, 1999 - v2
Checksum:iD5CE73A71CFECE48
GO
Isoform Abd-AI (identifier: Q07961-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Show »
Length:284
Mass (Da):31,491
Checksum:iDA6CD4A182BF36B8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959Missing in isoform Abd-AI. CuratedVSP_002395Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017415 mRNA. Translation: AAB70262.1.
AF017415 mRNA. Translation: AAB70263.1.
AF017414 Genomic DNA. Translation: AAB70261.1.
AF017414 Genomic DNA. Translation: AAB70260.1.
X72339 Genomic DNA. Translation: CAA51066.1.
RefSeqiNP_001034518.1. NM_001039429.1. [Q07961-1]
UniGeneiTca.5738.

Genome annotation databases

GeneIDi641595.
KEGGitca:641595.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017415 mRNA. Translation: AAB70262.1.
AF017415 mRNA. Translation: AAB70263.1.
AF017414 Genomic DNA. Translation: AAB70261.1.
AF017414 Genomic DNA. Translation: AAB70260.1.
X72339 Genomic DNA. Translation: CAA51066.1.
RefSeqiNP_001034518.1. NM_001039429.1. [Q07961-1]
UniGeneiTca.5738.

3D structure databases

ProteinModelPortaliQ07961.
SMRiQ07961. Positions 216-274.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi641595.
KEGGitca:641595.

Organism-specific databases

CTDi42037.

Phylogenomic databases

eggNOGiNOG328968.
KOiK09311.
OMAiTIQACTT.
PhylomeDBiQ07961.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR022132. Abdominal-A.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12407. Abdominal-A. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Brown S.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Georgia.
  2. "The Tribolium homeotic gene Abdominal is homologous to abdominal-A of the Drosophila bithorax complex."
    Stuart J.J., Brown S.J., Beeman R.W., Denell R.E.
    Development 117:233-243(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-343.

Entry informationi

Entry nameiABDA_TRICA
AccessioniPrimary (citable) accession number: Q07961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: June 24, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.