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Q07961

- ABDA_TRICA

UniProt

Q07961 - ABDA_TRICA

Protein

Homeobox protein abdominal-A homolog

Gene

ABD-A

Organism
Tribolium castaneum (Red flour beetle)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi216 – 27560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein abdominal-A homolog
    Gene namesi
    Name:ABD-A
    OrganismiTribolium castaneum (Red flour beetle)
    Taxonomic identifieri7070 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Homeobox protein abdominal-A homologPRO_0000200254Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7070.Q07961.

    Structurei

    3D structure databases

    ProteinModelPortaliQ07961.
    SMRiQ07961. Positions 216-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi36 – 449Poly-Ser
    Compositional biasi48 – 558Poly-Ser
    Compositional biasi68 – 714Poly-His
    Compositional biasi73 – 775Poly-Ala
    Compositional biasi243 – 2464Poly-Arg
    Compositional biasi297 – 3004Poly-Gln

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG328968.
    InParanoidiQ07961.
    KOiK09311.
    OMAiKSCRYTA.
    PhylomeDBiQ07961.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR022132. Abdominal-A.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF12407. Abdominal-A. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Abd-AII (identifier: Q07961-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSKFIIDSM LPKYHQQFHH QQLFQSATTE APAAYSSSSP SGSSPQHSSS    50
    SASTSPAARM YPYVSAAHHH HQAAAAAFGA AASGSMVPSF SSTASSALAA 100
    AVDAATDKSC RYTAGLAANV TPADSMVNYT LGQHHHNGAA VSAASSVSAA 150
    SASMAVAAQF YHQAASAVVD PLNSCSQPAA PGGQPIPDIP RYPWMSITDW 200
    MSPFDRVVCG PNGCPRRRGR QTYTRFQTLE LEKEFHFNHY LTRRRRIEIA 250
    HALCLTERQI KIWFQNRRMK LKKELRAVKE INEQARRERE EQERHKQQQQ 300
    EKQQKIEQQT HSSIHQHHHD PMKMSLDKSG GSDLLKAVSK VPT 343
    Length:343
    Mass (Da):37,772
    Last modified:July 15, 1999 - v2
    Checksum:iD5CE73A71CFECE48
    GO
    Isoform Abd-AI (identifier: Q07961-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-59: Missing.

    Show »
    Length:284
    Mass (Da):31,491
    Checksum:iDA6CD4A182BF36B8
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5959Missing in isoform Abd-AI. CuratedVSP_002395Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017415 mRNA. Translation: AAB70262.1.
    AF017415 mRNA. Translation: AAB70263.1.
    AF017414 Genomic DNA. Translation: AAB70261.1.
    AF017414 Genomic DNA. Translation: AAB70260.1.
    X72339 Genomic DNA. Translation: CAA51066.1.
    RefSeqiNP_001034518.1. NM_001039429.1. [Q07961-1]
    UniGeneiTca.5738.

    Genome annotation databases

    GeneIDi641595.
    KEGGitca:641595.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017415 mRNA. Translation: AAB70262.1 .
    AF017415 mRNA. Translation: AAB70263.1 .
    AF017414 Genomic DNA. Translation: AAB70261.1 .
    AF017414 Genomic DNA. Translation: AAB70260.1 .
    X72339 Genomic DNA. Translation: CAA51066.1 .
    RefSeqi NP_001034518.1. NM_001039429.1. [Q07961-1 ]
    UniGenei Tca.5738.

    3D structure databases

    ProteinModelPortali Q07961.
    SMRi Q07961. Positions 216-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7070.Q07961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 641595.
    KEGGi tca:641595.

    Organism-specific databases

    CTDi 42037.

    Phylogenomic databases

    eggNOGi NOG328968.
    InParanoidi Q07961.
    KOi K09311.
    OMAi KSCRYTA.
    PhylomeDBi Q07961.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR022132. Abdominal-A.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF12407. Abdominal-A. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Brown S.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: Georgia.
    2. "The Tribolium homeotic gene Abdominal is homologous to abdominal-A of the Drosophila bithorax complex."
      Stuart J.J., Brown S.J., Beeman R.W., Denell R.E.
      Development 117:233-243(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-343.

    Entry informationi

    Entry nameiABDA_TRICA
    AccessioniPrimary (citable) accession number: Q07961
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3