Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q07961 (ABDA_TRICA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein abdominal-A homolog
Gene names
Name:ABD-A
OrganismTribolium castaneum (Red flour beetle)
Taxonomic identifier7070 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Abd-AII (identifier: Q07961-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Abd-AI (identifier: Q07961-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Homeobox protein abdominal-A homolog
PRO_0000200254

Regions

DNA binding216 – 27560Homeobox
Compositional bias36 – 449Poly-Ser
Compositional bias48 – 558Poly-Ser
Compositional bias68 – 714Poly-His
Compositional bias73 – 775Poly-Ala
Compositional bias243 – 2464Poly-Arg
Compositional bias297 – 3004Poly-Gln

Natural variations

Alternative sequence1 – 5959Missing in isoform Abd-AI.
VSP_002395

Sequences

Sequence LengthMass (Da)Tools
Isoform Abd-AII [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: D5CE73A71CFECE48

FASTA34337,772
        10         20         30         40         50         60 
MSSKFIIDSM LPKYHQQFHH QQLFQSATTE APAAYSSSSP SGSSPQHSSS SASTSPAARM 

        70         80         90        100        110        120 
YPYVSAAHHH HQAAAAAFGA AASGSMVPSF SSTASSALAA AVDAATDKSC RYTAGLAANV 

       130        140        150        160        170        180 
TPADSMVNYT LGQHHHNGAA VSAASSVSAA SASMAVAAQF YHQAASAVVD PLNSCSQPAA 

       190        200        210        220        230        240 
PGGQPIPDIP RYPWMSITDW MSPFDRVVCG PNGCPRRRGR QTYTRFQTLE LEKEFHFNHY 

       250        260        270        280        290        300 
LTRRRRIEIA HALCLTERQI KIWFQNRRMK LKKELRAVKE INEQARRERE EQERHKQQQQ 

       310        320        330        340 
EKQQKIEQQT HSSIHQHHHD PMKMSLDKSG GSDLLKAVSK VPT 

« Hide

Isoform Abd-AI [UniParc].

Checksum: DA6CD4A182BF36B8
Show »

FASTA28431,491

References

[1]Brown S.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Georgia.
[2]"The Tribolium homeotic gene Abdominal is homologous to abdominal-A of the Drosophila bithorax complex."
Stuart J.J., Brown S.J., Beeman R.W., Denell R.E.
Development 117:233-243(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-343.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017415 mRNA. Translation: AAB70262.1.
AF017415 mRNA. Translation: AAB70263.1.
AF017414 Genomic DNA. Translation: AAB70261.1.
AF017414 Genomic DNA. Translation: AAB70260.1.
X72339 Genomic DNA. Translation: CAA51066.1.
RefSeqNP_001034518.1. NM_001039429.1. [Q07961-1]
UniGeneTca.5738.

3D structure databases

ProteinModelPortalQ07961.
SMRQ07961. Positions 216-274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7070.Q07961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID641595.
KEGGtca:641595.

Organism-specific databases

CTD42037.

Phylogenomic databases

eggNOGNOG328968.
InParanoidQ07961.
KOK09311.
OMAKSCRYTA.
PhylomeDBQ07961.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR022132. Abdominal-A.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF12407. Abdominal-A. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameABDA_TRICA
AccessionPrimary (citable) accession number: Q07961
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: May 14, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries