Q07961 (ABDA_TRICA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein abdominal-A homolog

Gene names

Name:

ABD-A

Organism

Tribolium castaneum (Red flour beetle)

Taxonomic identifier

7070 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Coleoptera › Polyphaga › Cucujiformia › Tenebrionoidea › Tenebrionidae › Tenebrionidae incertae sedis › Tribolium

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Abd-AII (identifier: Q07961-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Abd-AI (identifier: Q07961-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Homeobox protein abdominal-A homolog		PRO_0000200254
Regions
	DNA binding	216 – 275	60	Homeobox
	Compositional bias	36 – 44	9	Poly-Ser
	Compositional bias	48 – 55	8	Poly-Ser
	Compositional bias	68 – 71	4	Poly-His
	Compositional bias	73 – 77	5	Poly-Ala
	Compositional bias	243 – 246	4	Poly-Arg
	Compositional bias	297 – 300	4	Poly-Gln
Natural variations
	Alternative sequence	1 – 59	59	Missing in isoform Abd-AI.		VSP_002395

Sequences

	Sequence		Length	Mass (Da)
	Isoform Abd-AII [UniParc]. Last modified July 15, 1999. Version 2. Checksum: D5CE73A71CFECE48	FASTA	343	37,772
	10 20 30 40 50 60 MSSKFIIDSM LPKYHQQFHH QQLFQSATTE APAAYSSSSP SGSSPQHSSS SASTSPAARM 70 80 90 100 110 120 YPYVSAAHHH HQAAAAAFGA AASGSMVPSF SSTASSALAA AVDAATDKSC RYTAGLAANV 130 140 150 160 170 180 TPADSMVNYT LGQHHHNGAA VSAASSVSAA SASMAVAAQF YHQAASAVVD PLNSCSQPAA 190 200 210 220 230 240 PGGQPIPDIP RYPWMSITDW MSPFDRVVCG PNGCPRRRGR QTYTRFQTLE LEKEFHFNHY 250 260 270 280 290 300 LTRRRRIEIA HALCLTERQI KIWFQNRRMK LKKELRAVKE INEQARRERE EQERHKQQQQ 310 320 330 340 EKQQKIEQQT HSSIHQHHHD PMKMSLDKSG GSDLLKAVSK VPT
	Isoform Abd-AI [UniParc]. Checksum: DA6CD4A182BF36B8	FASTA	284	31,491
	10 20 30 40 50 60 MYPYVSAAHH HHQAAAAAFG AAASGSMVPS FSSTASSALA AAVDAATDKS CRYTAGLAAN 70 80 90 100 110 120 VTPADSMVNY TLGQHHHNGA AVSAASSVSA ASASMAVAAQ FYHQAASAVV DPLNSCSQPA 130 140 150 160 170 180 APGGQPIPDI PRYPWMSITD WMSPFDRVVC GPNGCPRRRG RQTYTRFQTL ELEKEFHFNH 190 200 210 220 230 240 YLTRRRRIEI AHALCLTERQ IKIWFQNRRM KLKKELRAVK EINEQARRER EEQERHKQQQ 250 260 270 280 QEKQQKIEQQ THSSIHQHHH DPMKMSLDKS GGSDLLKAVS KVPT

References

[1]	Brown S. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: Georgia.
[2]	"The Tribolium homeotic gene Abdominal is homologous to abdominal-A of the Drosophila bithorax complex." Stuart J.J., Brown S.J., Beeman R.W., Denell R.E. Development 117:233-243(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-343.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF017415 mRNA. Translation: AAB70262.1. AF017415 mRNA. Translation: AAB70263.1. AF017414 Genomic DNA. Translation: AAB70261.1. AF017414 Genomic DNA. Translation: AAB70260.1. X72339 Genomic DNA. Translation: CAA51066.1.
RefSeq	NP_001034518.1. NM_001039429.1.
UniGene	Tca.5738.
3D structure databases
ProteinModelPortal	Q07961.
SMR	Q07961. Positions 216-274.
ModBase	Search...
Protein-protein interaction databases
STRING	7070.Q07961.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	641595.
KEGG	tca:641595.
Organism-specific databases
CTD	42037.
Phylogenomic databases
eggNOG	NOG328968.
InParanoid	Q07961.
KO	K09311.
OMA	KSCRYTA.
OrthoDB	EOG4F7M1W.
PhylomeDB	Q07961.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR022132. Abdominal-A. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF12407. Abdominal-A. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABDA_TRICA

Accession

Primary (citable) accession number: Q07961

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 15, 1999
Last modified:	May 29, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)