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Protein

Rho GTPase-activating protein 1

Gene

ARHGAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei282Involved in G-protein binding to GAPsCurated1

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • GTPase activator activity Source: MGI
  • Rab GTPase binding Source: CAFA
  • SH3/SH2 adaptor activity Source: ProtInc
  • SH3 domain binding Source: UniProtKB-KW

GO - Biological processi

  • endosomal transport Source: CAFA
  • ferric iron import across plasma membrane Source: CAFA
  • negative regulation of endocytic recycling Source: CAFA
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • Rho protein signal transduction Source: ProtInc
  • small GTPase mediated signal transduction Source: MGI
  • transferrin transport Source: CAFA

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 1
Alternative name(s):
CDC42 GTPase-activating protein
GTPase-activating protein rhoGAP
Rho-related small GTPase protein activator
Rho-type GTPase-activating protein 1
p50-RhoGAP
Gene namesi
Name:ARHGAP1
Synonyms:CDC42GAP, RHOGAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000175220.11
HGNCiHGNC:673 ARHGAP1
MIMi602732 gene
neXtProtiNX_Q07960

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi392
OpenTargetsiENSG00000175220
PharmGKBiPA24956

Polymorphism and mutation databases

DMDMi3024550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567001 – 439Rho GTPase-activating protein 1Add BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei44PhosphoserineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei65PhosphotyrosineBy similarity1
Modified residuei80N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ07960
MaxQBiQ07960
PaxDbiQ07960
PeptideAtlasiQ07960
PRIDEiQ07960

2D gel databases

OGPiQ07960

PTM databases

iPTMnetiQ07960
PhosphoSitePlusiQ07960
SwissPalmiQ07960

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000175220
CleanExiHS_ARHGAP1
ExpressionAtlasiQ07960 baseline and differential
GenevisibleiQ07960 HS

Organism-specific databases

HPAiHPA004689
HPA008285

Interactioni

Subunit structurei

Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • Rab GTPase binding Source: CAFA
  • SH3/SH2 adaptor activity Source: ProtInc
  • SH3 domain binding Source: UniProtKB-KW

Protein-protein interaction databases

BioGridi106885, 41 interactors
DIPiDIP-6081N
IntActiQ07960, 19 interactors
MINTiQ07960
STRINGi9606.ENSP00000310491

Structurei

Secondary structure

1439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi242 – 244Combined sources3
Helixi246 – 252Combined sources7
Helixi261 – 273Combined sources13
Turni274 – 276Combined sources3
Turni278 – 282Combined sources5
Helixi287 – 298Combined sources12
Helixi305 – 307Combined sources3
Helixi312 – 324Combined sources13
Beta strandi325 – 327Combined sources3
Helixi332 – 334Combined sources3
Helixi335 – 339Combined sources5
Helixi341 – 343Combined sources3
Helixi346 – 348Combined sources3
Helixi349 – 357Combined sources9
Helixi362 – 380Combined sources19
Helixi382 – 385Combined sources4
Helixi389 – 400Combined sources12
Helixi406 – 411Combined sources6
Helixi413 – 425Combined sources13
Helixi427 – 430Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AM4X-ray2.70A/B/C233-431[»]
1GRNX-ray2.10B237-439[»]
1OW3X-ray1.80A198-439[»]
1RGPX-ray2.00A198-439[»]
1TX4X-ray1.65A234-431[»]
2NGRX-ray1.90B206-439[»]
5M6XX-ray2.40A/H198-437[»]
5M70X-ray2.20A/F198-437[»]
ProteinModelPortaliQ07960
SMRiQ07960
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07960

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 218CRAL-TRIOPROSITE-ProRule annotationAdd BLAST156
Domaini244 – 431Rho-GAPPROSITE-ProRule annotationAdd BLAST188

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi228 – 238SH3-bindingAdd BLAST11

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG4406 Eukaryota
ENOG410XR4J LUCA
GeneTreeiENSGT00760000118863
HOGENOMiHOG000231442
HOVERGENiHBG054433
InParanoidiQ07960
KOiK18470
OMAiNTFTKFL
OrthoDBiEOG091G07HT
PhylomeDBiQ07960
TreeFamiTF324164

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di1.10.555.10, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50238 RHOGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q07960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLSELQDD LTLDDTSEAL NQLKLASIDE KNWPSDEMPD FPKSDDSKSS
60 70 80 90 100
SPELVTHLKW DDPYYDIARH QIVEVAGDDK YGRKIIVFSA CRMPPSHQLD
110 120 130 140 150
HSKLLGYLKH TLDQYVESDY TLLYLHHGLT SDNKPSLSWL RDAYREFDRK
160 170 180 190 200
YKKNIKALYI VHPTMFIKTL LILFKPLISF KFGQKIFYVN YLSELSEHVK
210 220 230 240 250
LEQLGIPRQV LKYDDFLKST QKSPATAPKP MPPRPPLPNQ QFGVSLQHLQ
260 270 280 290 300
EKNPEQEPIP IVLRETVAYL QAHALTTEGI FRRSANTQVV REVQQKYNMG
310 320 330 340 350
LPVDFDQYNE LHLPAVILKT FLRELPEPLL TFDLYPHVVG FLNIDESQRV
360 370 380 390 400
PATLQVLQTL PEENYQVLRF LTAFLVQISA HSDQNKMTNT NLAVVFGPNL
410 420 430
LWAKDAAITL KAINPINTFT KFLLDHQGEL FPSPDPSGL
Length:439
Mass (Da):50,436
Last modified:November 1, 1996 - v1
Checksum:i4DD0CC4419849C35
GO

Sequence cautioni

The sequence AAA16142 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049137369R → C. Corresponds to variant dbSNP:rs11822837Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02570 mRNA Translation: AAA16142.1 Different initiation.
Z23024 mRNA Translation: CAA80560.1
CH471064 Genomic DNA Translation: EAW67983.1
CH471064 Genomic DNA Translation: EAW67984.1
BC018118 mRNA Translation: AAH18118.1
CCDSiCCDS7922.1
PIRiA49678
RefSeqiNP_004299.1, NM_004308.3
XP_011518397.1, XM_011520095.1
UniGeneiHs.138860

Genome annotation databases

EnsembliENST00000311956; ENSP00000310491; ENSG00000175220
GeneIDi392
KEGGihsa:392
UCSCiuc001ndd.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRHG01_HUMAN
AccessioniPrimary (citable) accession number: Q07960
Secondary accession number(s): D3DQQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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