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Protein

Ribosome maturation protein SDO1

Gene

SDO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with the EF-2-like GTPase RIA1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.2 Publications

Miscellaneous

Present with 5060 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: SGD
  • RNA binding Source: GO_Central

GO - Biological processi

  • mature ribosome assembly Source: SGD
  • rRNA processing Source: GO_Central

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-32183-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome maturation protein SDO1
Gene namesi
Name:SDO1
Ordered Locus Names:YLR022C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR022C
SGDiS000004012 SDO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31C → W: Impairs protein folding and stability. Loss of function. 1 Publication1
Mutagenesisi34N → I: Impairs protein folding and stability. Loss of function. 1 Publication1
Mutagenesisi71L → P: Impairs protein folding and stability. Loss of function. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL1741198

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237641 – 250Ribosome maturation protein SDO1Add BLAST250

Proteomic databases

MaxQBiQ07953
PaxDbiQ07953
PRIDEiQ07953

Interactioni

Subunit structurei

Associates with the 60S ribosomal subunit.

Binary interactionsi

Show more details

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: SGD

Protein-protein interaction databases

BioGridi31296, 258 interactors
IntActiQ07953, 37 interactors
MINTiQ07953
STRINGi4932.YLR022C

Structurei

3D structure databases

ProteinModelPortaliQ07953
SMRiQ07953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SDO1/SBDS family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000008135
HOGENOMiHOG000216685
InParanoidiQ07953
KOiK14574
OMAiAVNPQMD
OrthoDBiEOG092C52XD

Family and domain databases

Gene3Di1.10.10.900, 1 hit
3.30.1250.10, 1 hit
InterProiView protein in InterPro
IPR018978 Ribosome_mat_SBDS_C
IPR018023 Ribosome_mat_SBDS_CS
IPR019783 Ribosome_mat_SBDS_N
IPR036786 Ribosome_mat_SBDS_N_sf
IPR002140 Sdo1/SBDS
IPR037188 Sdo1/SBDS_central_sf
PANTHERiPTHR10927:SF1 PTHR10927:SF1, 1 hit
PfamiView protein in Pfam
PF01172 SBDS, 1 hit
PF09377 SBDS_C, 1 hit
SUPFAMiSSF109728 SSF109728, 1 hit
SSF89895 SSF89895, 1 hit
TIGRFAMsiTIGR00291 RNA_SBDS, 1 hit
PROSITEiView protein in PROSITE
PS01267 UPF0023, 1 hit

Sequencei

Sequence statusi: Complete.

Q07953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPINQPSGQI KLTNVSLVRL KKARKRFEVA CYQNKVQDYR KGIEKDLDEV
60 70 80 90 100
LQIHQVFMNV SKGLVANKED LQKCFGTTNV DDVIEEIMHK GEIQLSEKER
110 120 130 140 150
QLMLNKVNNE MLTIVSAKCI NPVSKKRYPP TMIHKALQEL KFSPVINKPA
160 170 180 190 200
KLQALEAIKL LVSKQIIPIV RAKMKVKVAI SEPSRQPELI EKISKLIASS
210 220 230 240 250
PGESTKPELD PWTCTGLIDP VNYRDLMTLC DKKGTVQVLD MAVIDNTTHN
Length:250
Mass (Da):28,283
Last modified:November 1, 1996 - v1
Checksum:iEFC799ADEFF73E0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73194 Genomic DNA Translation: CAA97545.1
BK006945 Genomic DNA Translation: DAA09340.1
PIRiS64849
RefSeqiNP_013122.1, NM_001181909.1

Genome annotation databases

EnsemblFungiiYLR022C; YLR022C; YLR022C
GeneIDi850709
KEGGisce:YLR022C

Similar proteinsi

Entry informationi

Entry nameiSDO1_YEAST
AccessioniPrimary (citable) accession number: Q07953
Secondary accession number(s): D6VY24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health