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Q07951

- POC3_YEAST

UniProt

Q07951 - POC3_YEAST

Protein

Proteasome chaperone 3

Gene

IRC25

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in 20S proteasome assembly, facilitating the alpha-ring formation.2 Publications

    GO - Biological processi

    1. chaperone-mediated protein complex assembly Source: SGD
    2. nuclear-transcribed mRNA catabolic process, non-stop decay Source: SGD
    3. proteasome assembly Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32182-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome chaperone 3
    Alternative name(s):
    Increased recombination centers protein 25
    Gene namesi
    Name:IRC25
    Synonyms:DMP2, POC3
    Ordered Locus Names:YLR021W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR021w.
    SGDiS000004011. IRC25.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Proteasome chaperone 3PRO_0000247202Add
    BLAST

    Proteomic databases

    MaxQBiQ07951.
    PaxDbiQ07951.

    Expressioni

    Gene expression databases

    GenevestigatoriQ07951.

    Interactioni

    Subunit structurei

    Component of the 20S proteasome chaperone. Forms a heterodimer with POC4 that binds to proteasome precursors. Interacts with POP2.2 Publications

    Protein-protein interaction databases

    BioGridi31295. 51 interactions.
    DIPiDIP-4747N.
    IntActiQ07951. 3 interactions.
    MINTiMINT-550062.
    STRINGi4932.YLR021W.

    Structurei

    Secondary structure

    1
    179
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 108
    Beta strandi26 – 338
    Beta strandi38 – 447
    Beta strandi50 – 567
    Helixi84 – 918
    Beta strandi95 – 1028
    Helixi109 – 12214
    Beta strandi140 – 1456
    Helixi147 – 1493
    Helixi162 – 17615

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Z5BX-ray1.96B1-179[»]
    2Z5CX-ray2.90B/E1-179[»]
    ProteinModelPortaliQ07951.
    SMRiQ07951. Positions 1-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ07951.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PSMG3 family.Curated

    Phylogenomic databases

    eggNOGiNOG47807.
    HOGENOMiHOG000115599.
    KOiK11881.
    OMAiTHFNNTI.
    OrthoDBiEOG7HXD32.

    Family and domain databases

    InterProiIPR018854. Psome_chaperone_3/4_fun.
    [Graphical view]
    PfamiPF10448. chaperone_DMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q07951-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISYEFQTHL PKGKDSSLNA SSENKELYVQ ATHFNNTILL QIRLNGEMDS    50
    TYEVSSKGLN PILDINVPLA GNLGNTGGDY DDEEEEFVRD HLSDYQVVTK 100
    LGDSADPKVP VVCVQIAELY RRVILPEVSG TMAQDNMQFS LLISMSSKIW 150
    RATKEQSADD NDFGKLVFVL KCIKDMYAK 179
    Length:179
    Mass (Da):20,061
    Last modified:November 1, 1996 - v1
    Checksum:i6CA25E8ED0491EE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73193 Genomic DNA. Translation: CAA97544.1.
    AY558201 Genomic DNA. Translation: AAS56527.1.
    BK006945 Genomic DNA. Translation: DAA09339.1.
    PIRiS64843.
    RefSeqiNP_013121.1. NM_001181908.1.

    Genome annotation databases

    EnsemblFungiiYLR021W; YLR021W; YLR021W.
    GeneIDi850708.
    KEGGisce:YLR021W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z73193 Genomic DNA. Translation: CAA97544.1 .
    AY558201 Genomic DNA. Translation: AAS56527.1 .
    BK006945 Genomic DNA. Translation: DAA09339.1 .
    PIRi S64843.
    RefSeqi NP_013121.1. NM_001181908.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Z5B X-ray 1.96 B 1-179 [» ]
    2Z5C X-ray 2.90 B/E 1-179 [» ]
    ProteinModelPortali Q07951.
    SMRi Q07951. Positions 1-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31295. 51 interactions.
    DIPi DIP-4747N.
    IntActi Q07951. 3 interactions.
    MINTi MINT-550062.
    STRINGi 4932.YLR021W.

    Proteomic databases

    MaxQBi Q07951.
    PaxDbi Q07951.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR021W ; YLR021W ; YLR021W .
    GeneIDi 850708.
    KEGGi sce:YLR021W.

    Organism-specific databases

    CYGDi YLR021w.
    SGDi S000004011. IRC25.

    Phylogenomic databases

    eggNOGi NOG47807.
    HOGENOMi HOG000115599.
    KOi K11881.
    OMAi THFNNTI.
    OrthoDBi EOG7HXD32.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32182-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q07951.
    NextBioi 966760.

    Gene expression databases

    Genevestigatori Q07951.

    Family and domain databases

    InterProi IPR018854. Psome_chaperone_3/4_fun.
    [Graphical view ]
    Pfami PF10448. chaperone_DMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals."
      Le Tallec B., Barrault M.-B., Courbeyrette R., Guerois R., Marsolier-Kergoat M.-C., Peyroche A.
      Mol. Cell 27:660-674(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NAME, FUNCTION, INTERACTION WITH POC4, SUBUNIT.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH POC4 AND PUP2, FUNCTION.

    Entry informationi

    Entry nameiPOC3_YEAST
    AccessioniPrimary (citable) accession number: Q07951
    Secondary accession number(s): D6VY23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1820 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3