SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q07951

- POC3_YEAST

UniProt

Q07951 - POC3_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proteasome chaperone 3

Gene
IRC25, DMP2, POC3, YLR021W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in 20S proteasome assembly, facilitating the alpha-ring formation.2 Publications

GO - Biological processi

  1. chaperone-mediated protein complex assembly Source: SGD
  2. nuclear-transcribed mRNA catabolic process, non-stop decay Source: SGD
  3. proteasome assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-32182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome chaperone 3
Alternative name(s):
Increased recombination centers protein 25
Gene namesi
Name:IRC25
Synonyms:DMP2, POC3
Ordered Locus Names:YLR021W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR021w.
SGDiS000004011. IRC25.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Proteasome chaperone 3PRO_0000247202Add
BLAST

Proteomic databases

MaxQBiQ07951.
PaxDbiQ07951.

Expressioni

Gene expression databases

GenevestigatoriQ07951.

Interactioni

Subunit structurei

Component of the 20S proteasome chaperone. Forms a heterodimer with POC4 that binds to proteasome precursors. Interacts with POP2.1 Publication

Protein-protein interaction databases

BioGridi31295. 51 interactions.
DIPiDIP-4747N.
IntActiQ07951. 3 interactions.
MINTiMINT-550062.
STRINGi4932.YLR021W.

Structurei

Secondary structure

1
179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108
Beta strandi26 – 338
Beta strandi38 – 447
Beta strandi50 – 567
Helixi84 – 918
Beta strandi95 – 1028
Helixi109 – 12214
Beta strandi140 – 1456
Helixi147 – 1493
Helixi162 – 17615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5BX-ray1.96B1-179[»]
2Z5CX-ray2.90B/E1-179[»]
ProteinModelPortaliQ07951.
SMRiQ07951. Positions 1-178.

Miscellaneous databases

EvolutionaryTraceiQ07951.

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG3 family.

Phylogenomic databases

eggNOGiNOG47807.
HOGENOMiHOG000115599.
KOiK11881.
OMAiTHFNNTI.
OrthoDBiEOG7HXD32.

Family and domain databases

InterProiIPR018854. Psome_chaperone_3/4_fun.
[Graphical view]
PfamiPF10448. chaperone_DMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07951-1 [UniParc]FASTAAdd to Basket

« Hide

MISYEFQTHL PKGKDSSLNA SSENKELYVQ ATHFNNTILL QIRLNGEMDS    50
TYEVSSKGLN PILDINVPLA GNLGNTGGDY DDEEEEFVRD HLSDYQVVTK 100
LGDSADPKVP VVCVQIAELY RRVILPEVSG TMAQDNMQFS LLISMSSKIW 150
RATKEQSADD NDFGKLVFVL KCIKDMYAK 179
Length:179
Mass (Da):20,061
Last modified:November 1, 1996 - v1
Checksum:i6CA25E8ED0491EE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73193 Genomic DNA. Translation: CAA97544.1.
AY558201 Genomic DNA. Translation: AAS56527.1.
BK006945 Genomic DNA. Translation: DAA09339.1.
PIRiS64843.
RefSeqiNP_013121.1. NM_001181908.1.

Genome annotation databases

EnsemblFungiiYLR021W; YLR021W; YLR021W.
GeneIDi850708.
KEGGisce:YLR021W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z73193 Genomic DNA. Translation: CAA97544.1 .
AY558201 Genomic DNA. Translation: AAS56527.1 .
BK006945 Genomic DNA. Translation: DAA09339.1 .
PIRi S64843.
RefSeqi NP_013121.1. NM_001181908.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Z5B X-ray 1.96 B 1-179 [» ]
2Z5C X-ray 2.90 B/E 1-179 [» ]
ProteinModelPortali Q07951.
SMRi Q07951. Positions 1-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31295. 51 interactions.
DIPi DIP-4747N.
IntActi Q07951. 3 interactions.
MINTi MINT-550062.
STRINGi 4932.YLR021W.

Proteomic databases

MaxQBi Q07951.
PaxDbi Q07951.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR021W ; YLR021W ; YLR021W .
GeneIDi 850708.
KEGGi sce:YLR021W.

Organism-specific databases

CYGDi YLR021w.
SGDi S000004011. IRC25.

Phylogenomic databases

eggNOGi NOG47807.
HOGENOMi HOG000115599.
KOi K11881.
OMAi THFNNTI.
OrthoDBi EOG7HXD32.

Enzyme and pathway databases

BioCyci YEAST:G3O-32182-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q07951.
NextBioi 966760.

Gene expression databases

Genevestigatori Q07951.

Family and domain databases

InterProi IPR018854. Psome_chaperone_3/4_fun.
[Graphical view ]
Pfami PF10448. chaperone_DMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals."
    Le Tallec B., Barrault M.-B., Courbeyrette R., Guerois R., Marsolier-Kergoat M.-C., Peyroche A.
    Mol. Cell 27:660-674(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME, FUNCTION, INTERACTION WITH POC4, SUBUNIT.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH POC4 AND PUP2, FUNCTION.

Entry informationi

Entry nameiPOC3_YEAST
AccessioniPrimary (citable) accession number: Q07951
Secondary accession number(s): D6VY23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1820 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

Similar proteinsi