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Q07951 (POC3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome chaperone 3
Alternative name(s):
Increased recombination centers protein 25
Gene names
Name:IRC25
Synonyms:DMP2, POC3
Ordered Locus Names:YLR021W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in 20S proteasome assembly, facilitating the alpha-ring formation. Ref.5 Ref.6

Subunit structure

Component of the 20S proteasome chaperone. Forms a heterodimer with POC4 that binds to proteasome precursors. Interacts with POP2. Ref.5

Miscellaneous

Present with 1820 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the PSMG3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Proteasome chaperone 3
PRO_0000247202

Secondary structure

..................... 179
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q07951 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6CA25E8ED0491EE2

FASTA17920,061
        10         20         30         40         50         60 
MISYEFQTHL PKGKDSSLNA SSENKELYVQ ATHFNNTILL QIRLNGEMDS TYEVSSKGLN 

        70         80         90        100        110        120 
PILDINVPLA GNLGNTGGDY DDEEEEFVRD HLSDYQVVTK LGDSADPKVP VVCVQIAELY 

       130        140        150        160        170 
RRVILPEVSG TMAQDNMQFS LLISMSSKIW RATKEQSADD NDFGKLVFVL KCIKDMYAK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals."
Le Tallec B., Barrault M.-B., Courbeyrette R., Guerois R., Marsolier-Kergoat M.-C., Peyroche A.
Mol. Cell 27:660-674(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE NAME, FUNCTION, INTERACTION WITH POC4, SUBUNIT.
[6]"Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes."
Yashiroda H., Mizushima T., Okamoto K., Kameyama T., Hayashi H., Kishimoto T., Niwa S., Kasahara M., Kurimoto E., Sakata E., Takagi K., Suzuki A., Hirano Y., Murata S., Kato K., Yamane T., Tanaka K.
Nat. Struct. Mol. Biol. 15:228-236(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH POC4 AND PUP2, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z73193 Genomic DNA. Translation: CAA97544.1.
AY558201 Genomic DNA. Translation: AAS56527.1.
BK006945 Genomic DNA. Translation: DAA09339.1.
PIRS64843.
RefSeqNP_013121.1. NM_001181908.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5BX-ray1.96B1-179[»]
2Z5CX-ray2.90B/E1-179[»]
ProteinModelPortalQ07951.
SMRQ07951. Positions 1-178.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31295. 51 interactions.
DIPDIP-4747N.
IntActQ07951. 3 interactions.
MINTMINT-550062.
STRING4932.YLR021W.

Proteomic databases

PaxDbQ07951.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR021W; YLR021W; YLR021W.
GeneID850708.
KEGGsce:YLR021W.

Organism-specific databases

CYGDYLR021w.
SGDS000004011. IRC25.

Phylogenomic databases

eggNOGNOG47807.
HOGENOMHOG000115599.
KOK11881.
OMAEMDSTYE.
OrthoDBEOG7HXD32.

Enzyme and pathway databases

BioCycYEAST:G3O-32182-MONOMER.

Gene expression databases

GenevestigatorQ07951.

Family and domain databases

InterProIPR018854. Psome_chaperone_3/4_fun.
[Graphical view]
PfamPF10448. chaperone_DMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ07951.
NextBio966760.

Entry information

Entry namePOC3_YEAST
AccessionPrimary (citable) accession number: Q07951
Secondary accession number(s): D6VY23
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references