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Protein

Proteasome chaperone 3

Gene

IRC25

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in 20S proteasome assembly, facilitating the alpha-ring formation.2 Publications

GO - Biological processi

  1. chaperone-mediated protein complex assembly Source: SGD
  2. nuclear-transcribed mRNA catabolic process, non-stop decay Source: SGD
  3. proteasome assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-32182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome chaperone 3
Alternative name(s):
Increased recombination centers protein 25
Gene namesi
Name:IRC25
Synonyms:DMP2, POC3
Ordered Locus Names:YLR021W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR021w.
SGDiS000004011. IRC25.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Proteasome chaperone 3PRO_0000247202Add
BLAST

Proteomic databases

MaxQBiQ07951.
PaxDbiQ07951.

Expressioni

Gene expression databases

GenevestigatoriQ07951.

Interactioni

Subunit structurei

Component of the 20S proteasome chaperone. Forms a heterodimer with POC4 that binds to proteasome precursors. Interacts with POP2.2 Publications

Protein-protein interaction databases

BioGridi31295. 52 interactions.
DIPiDIP-4747N.
IntActiQ07951. 3 interactions.
MINTiMINT-550062.
STRINGi4932.YLR021W.

Structurei

Secondary structure

1
179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108Combined sources
Beta strandi26 – 338Combined sources
Beta strandi38 – 447Combined sources
Beta strandi50 – 567Combined sources
Helixi84 – 918Combined sources
Beta strandi95 – 1028Combined sources
Helixi109 – 12214Combined sources
Beta strandi140 – 1456Combined sources
Helixi147 – 1493Combined sources
Helixi162 – 17615Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5BX-ray1.96B1-179[»]
2Z5CX-ray2.90B/E1-179[»]
ProteinModelPortaliQ07951.
SMRiQ07951. Positions 1-178.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07951.

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG3 family.Curated

Phylogenomic databases

eggNOGiNOG47807.
HOGENOMiHOG000115599.
InParanoidiQ07951.
KOiK11881.
OMAiEMDSTYE.
OrthoDBiEOG7HXD32.

Family and domain databases

InterProiIPR018854. Psome_chaperone_3/4_fun.
[Graphical view]
PfamiPF10448. chaperone_DMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07951-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISYEFQTHL PKGKDSSLNA SSENKELYVQ ATHFNNTILL QIRLNGEMDS
60 70 80 90 100
TYEVSSKGLN PILDINVPLA GNLGNTGGDY DDEEEEFVRD HLSDYQVVTK
110 120 130 140 150
LGDSADPKVP VVCVQIAELY RRVILPEVSG TMAQDNMQFS LLISMSSKIW
160 170
RATKEQSADD NDFGKLVFVL KCIKDMYAK
Length:179
Mass (Da):20,061
Last modified:November 1, 1996 - v1
Checksum:i6CA25E8ED0491EE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73193 Genomic DNA. Translation: CAA97544.1.
AY558201 Genomic DNA. Translation: AAS56527.1.
BK006945 Genomic DNA. Translation: DAA09339.1.
PIRiS64843.
RefSeqiNP_013121.1. NM_001181908.1.

Genome annotation databases

EnsemblFungiiYLR021W; YLR021W; YLR021W.
GeneIDi850708.
KEGGisce:YLR021W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73193 Genomic DNA. Translation: CAA97544.1.
AY558201 Genomic DNA. Translation: AAS56527.1.
BK006945 Genomic DNA. Translation: DAA09339.1.
PIRiS64843.
RefSeqiNP_013121.1. NM_001181908.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z5BX-ray1.96B1-179[»]
2Z5CX-ray2.90B/E1-179[»]
ProteinModelPortaliQ07951.
SMRiQ07951. Positions 1-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31295. 52 interactions.
DIPiDIP-4747N.
IntActiQ07951. 3 interactions.
MINTiMINT-550062.
STRINGi4932.YLR021W.

Proteomic databases

MaxQBiQ07951.
PaxDbiQ07951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR021W; YLR021W; YLR021W.
GeneIDi850708.
KEGGisce:YLR021W.

Organism-specific databases

CYGDiYLR021w.
SGDiS000004011. IRC25.

Phylogenomic databases

eggNOGiNOG47807.
HOGENOMiHOG000115599.
InParanoidiQ07951.
KOiK11881.
OMAiEMDSTYE.
OrthoDBiEOG7HXD32.

Enzyme and pathway databases

BioCyciYEAST:G3O-32182-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ07951.
NextBioi966760.

Gene expression databases

GenevestigatoriQ07951.

Family and domain databases

InterProiIPR018854. Psome_chaperone_3/4_fun.
[Graphical view]
PfamiPF10448. chaperone_DMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals."
    Le Tallec B., Barrault M.-B., Courbeyrette R., Guerois R., Marsolier-Kergoat M.-C., Peyroche A.
    Mol. Cell 27:660-674(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME, FUNCTION, INTERACTION WITH POC4, SUBUNIT.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH POC4 AND PUP2, FUNCTION.

Entry informationi

Entry nameiPOC3_YEAST
AccessioniPrimary (citable) accession number: Q07951
Secondary accession number(s): D6VY23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1820 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.