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Protein

Proteasome chaperone 3

Gene

IRC25

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in 20S proteasome assembly, facilitating the alpha-ring formation.2 Publications

Miscellaneous

Present with 1820 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • chaperone-mediated protein complex assembly Source: SGD
  • nuclear-transcribed mRNA catabolic process, non-stop decay Source: SGD
  • proteasome assembly Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-32182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome chaperone 3
Alternative name(s):
Increased recombination centers protein 25
Gene namesi
Name:IRC25
Synonyms:DMP2, POC3
Ordered Locus Names:YLR021W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR021W.
SGDiS000004011. IRC25.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472021 – 179Proteasome chaperone 3Add BLAST179

Proteomic databases

MaxQBiQ07951.
PRIDEiQ07951.

Interactioni

Subunit structurei

Component of the 20S proteasome chaperone. Forms a heterodimer with POC4 that binds to proteasome precursors. Interacts with POP2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POC4Q1224512EBI-31959,EBI-2343020

Protein-protein interaction databases

BioGridi31295. 182 interactors.
DIPiDIP-4747N.
IntActiQ07951. 4 interactors.
MINTiMINT-550062.
STRINGi4932.YLR021W.

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Beta strandi26 – 33Combined sources8
Beta strandi38 – 44Combined sources7
Beta strandi50 – 56Combined sources7
Helixi84 – 91Combined sources8
Beta strandi95 – 102Combined sources8
Helixi109 – 122Combined sources14
Beta strandi140 – 145Combined sources6
Helixi147 – 149Combined sources3
Helixi162 – 176Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z5BX-ray1.96B1-179[»]
2Z5CX-ray2.90B/E1-179[»]
ProteinModelPortaliQ07951.
SMRiQ07951.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07951.

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG3 family.Curated

Phylogenomic databases

HOGENOMiHOG000115599.
InParanoidiQ07951.
KOiK11881.
OMAiNGEMDAT.
OrthoDBiEOG092C4UFH.

Family and domain databases

InterProiView protein in InterPro
IPR018854. Psome_chaperone_3/4.
PfamiView protein in Pfam
PF10448. POC3_POC4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISYEFQTHL PKGKDSSLNA SSENKELYVQ ATHFNNTILL QIRLNGEMDS
60 70 80 90 100
TYEVSSKGLN PILDINVPLA GNLGNTGGDY DDEEEEFVRD HLSDYQVVTK
110 120 130 140 150
LGDSADPKVP VVCVQIAELY RRVILPEVSG TMAQDNMQFS LLISMSSKIW
160 170
RATKEQSADD NDFGKLVFVL KCIKDMYAK
Length:179
Mass (Da):20,061
Last modified:November 1, 1996 - v1
Checksum:i6CA25E8ED0491EE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73193 Genomic DNA. Translation: CAA97544.1.
AY558201 Genomic DNA. Translation: AAS56527.1.
BK006945 Genomic DNA. Translation: DAA09339.1.
PIRiS64843.
RefSeqiNP_013121.1. NM_001181908.1.

Genome annotation databases

EnsemblFungiiYLR021W; YLR021W; YLR021W.
GeneIDi850708.
KEGGisce:YLR021W.

Similar proteinsi

Entry informationi

Entry nameiPOC3_YEAST
AccessioniPrimary (citable) accession number: Q07951
Secondary accession number(s): D6VY23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names