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Protein

Probable phosphatase PSR2

Gene

PSR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable phosphatase. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR1. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.1 Publication2 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to salt stress Source: SGD
  • protein dephosphorylation Source: GOC
  • response to heat Source: UniProtKB
  • response to salt stress Source: UniProtKB
  • response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-32180-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatase PSR2 (EC:3.1.3.-)
Alternative name(s):
Plasma membrane sodium response protein 2
Gene namesi
Name:PSR2
Ordered Locus Names:YLR019W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR019W.
SGDiS000004009. PSR2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Probable phosphatase PSR2PRO_0000212577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi9 – 91S-palmitoyl cysteine1 PublicationSequence analysis
Lipidationi10 – 101S-palmitoyl cysteine1 PublicationSequence analysis

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ07949.

PTM databases

iPTMnetiQ07949.
SwissPalmiQ07949.

Interactioni

Protein-protein interaction databases

BioGridi31293. 30 interactions.
DIPiDIP-4181N.
IntActiQ07949. 13 interactions.
MINTiMINT-512086.

Structurei

3D structure databases

ProteinModelPortaliQ07949.
SMRiQ07949. Positions 227-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini223 – 381159FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017194.
HOGENOMiHOG000211190.
InParanoidiQ07949.
KOiK15731.
OrthoDBiEOG7VDZ0W.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q07949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFIANILCC SSDTSKTHRQ RQPPETNHNR NRNRKHSSNK AQTQGRKQKA
60 70 80 90 100
TPNGDKMQYS TPEILLSSSD SGSNAGSKTM QENGNSGNGK LAPLSRDHSN
110 120 130 140 150
NSYDEEKEYE DYNEGDVEMT EVNNAGEEEE EDDEAKEKQD HVVHEYNVDA
160 170 180 190 200
DRNSSINDEA PPQQGLYQVG QEDMNPQYVA SSPDNDLNLI PTTEEDFSDL
210 220 230 240 250
THLQPDQYHA PGYDTLLPPK LQEFQQKKCL ILDLDETLVH SSFKYMHSAD
260 270 280 290 300
FVLPVEIDDQ VHNVYVIKRP GVDEFLNRVS QLYEVVVFTA SVSRYANPLL
310 320 330 340 350
DTLDPNGTIH HRLFREACYN YEGNYIKNLS QIGRPLSETI ILDNSPASYI
360 370 380 390
FHPQHAVPIS SWFSDTHDNE LLDIIPLLED LSSGNVLDVG SVLDVTI
Length:397
Mass (Da):44,772
Last modified:November 1, 1996 - v1
Checksum:iBEA0BB453C496B06
GO

Sequence cautioni

The sequence CAA62154.1 differs from that shown. Reason: Frameshift at position 193. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591Y → C in AAT93100 (PubMed:17322287).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73191 Genomic DNA. Translation: CAA97541.1.
AY693081 Genomic DNA. Translation: AAT93100.1.
X90564 Genomic DNA. Translation: CAA62154.1. Frameshift.
BK006945 Genomic DNA. Translation: DAA09337.1.
PIRiS64841.
RefSeqiNP_013119.1. NM_001181906.1.

Genome annotation databases

EnsemblFungiiYLR019W; YLR019W; YLR019W.
GeneIDi850706.
KEGGisce:YLR019W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73191 Genomic DNA. Translation: CAA97541.1.
AY693081 Genomic DNA. Translation: AAT93100.1.
X90564 Genomic DNA. Translation: CAA62154.1. Frameshift.
BK006945 Genomic DNA. Translation: DAA09337.1.
PIRiS64841.
RefSeqiNP_013119.1. NM_001181906.1.

3D structure databases

ProteinModelPortaliQ07949.
SMRiQ07949. Positions 227-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31293. 30 interactions.
DIPiDIP-4181N.
IntActiQ07949. 13 interactions.
MINTiMINT-512086.

PTM databases

iPTMnetiQ07949.
SwissPalmiQ07949.

Proteomic databases

MaxQBiQ07949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR019W; YLR019W; YLR019W.
GeneIDi850706.
KEGGisce:YLR019W.

Organism-specific databases

EuPathDBiFungiDB:YLR019W.
SGDiS000004009. PSR2.

Phylogenomic databases

GeneTreeiENSGT00390000017194.
HOGENOMiHOG000211190.
InParanoidiQ07949.
KOiK15731.
OrthoDBiEOG7VDZ0W.

Enzyme and pathway databases

BioCyciYEAST:G3O-32180-MONOMER.

Miscellaneous databases

NextBioi966754.
PROiQ07949.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "A 7.8kb fragment from chromosome XII of Saccharomyces cerevisiae does not harbour PKC2."
    Saville S.P., Atkinson S., Jamieson L., Pocklington M.J., Orr E.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-332.
    Strain: ATCC 204508 / S288c.
  5. "Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast."
    Siniossoglou S., Hurt E.C., Pelham H.R.B.
    J. Biol. Chem. 275:19352-19360(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, POSSIBLE PALMITOYLATION.
  6. "Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression."
    Kaida D., Yashiroda H., Toh-e A., Kikuchi Y.
    Genes Cells 7:543-552(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPSR2_YEAST
AccessioniPrimary (citable) accession number: Q07949
Secondary accession number(s): D6VY21, Q06898, Q6B1J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.