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Protein

Probable phosphatase PSR2

Gene

PSR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable phosphatase. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR1. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2.1 Publication2 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to salt stress Source: SGD
  • protein dephosphorylation Source: SGD
  • response to heat Source: SGD
  • response to salt stress Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-32180-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatase PSR2 (EC:3.1.3.-)
Alternative name(s):
Plasma membrane sodium response protein 2
Gene namesi
Name:PSR2
Ordered Locus Names:YLR019W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR019W
SGDiS000004009 PSR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125771 – 397Probable phosphatase PSR2Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi9S-palmitoyl cysteine1 Publication1
Lipidationi10S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ07949
PaxDbiQ07949
PRIDEiQ07949

PTM databases

iPTMnetiQ07949
SwissPalmiQ07949

Interactioni

Protein-protein interaction databases

BioGridi31293, 89 interactors
DIPiDIP-4181N
IntActiQ07949, 16 interactors
MINTiQ07949
STRINGi4932.YLR019W

Structurei

3D structure databases

ProteinModelPortaliQ07949
SMRiQ07949
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 381FCP1 homologyPROSITE-ProRule annotationAdd BLAST159

Phylogenomic databases

GeneTreeiENSGT00390000017194
HOGENOMiHOG000211190
InParanoidiQ07949
KOiK15731
OrthoDBiEOG092C5CYS

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR011948 Dullard_phosphatase
IPR004274 FCP1_dom
IPR036412 HAD-like_sf
IPR023214 HAD_sf
PfamiView protein in Pfam
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02251 HIF-SF_euk, 1 hit
PROSITEiView protein in PROSITE
PS50969 FCP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q07949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFIANILCC SSDTSKTHRQ RQPPETNHNR NRNRKHSSNK AQTQGRKQKA
60 70 80 90 100
TPNGDKMQYS TPEILLSSSD SGSNAGSKTM QENGNSGNGK LAPLSRDHSN
110 120 130 140 150
NSYDEEKEYE DYNEGDVEMT EVNNAGEEEE EDDEAKEKQD HVVHEYNVDA
160 170 180 190 200
DRNSSINDEA PPQQGLYQVG QEDMNPQYVA SSPDNDLNLI PTTEEDFSDL
210 220 230 240 250
THLQPDQYHA PGYDTLLPPK LQEFQQKKCL ILDLDETLVH SSFKYMHSAD
260 270 280 290 300
FVLPVEIDDQ VHNVYVIKRP GVDEFLNRVS QLYEVVVFTA SVSRYANPLL
310 320 330 340 350
DTLDPNGTIH HRLFREACYN YEGNYIKNLS QIGRPLSETI ILDNSPASYI
360 370 380 390
FHPQHAVPIS SWFSDTHDNE LLDIIPLLED LSSGNVLDVG SVLDVTI
Length:397
Mass (Da):44,772
Last modified:November 1, 1996 - v1
Checksum:iBEA0BB453C496B06
GO

Sequence cautioni

The sequence CAA62154 differs from that shown. Reason: Frameshift at position 193.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59Y → C in AAT93100 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73191 Genomic DNA Translation: CAA97541.1
AY693081 Genomic DNA Translation: AAT93100.1
X90564 Genomic DNA Translation: CAA62154.1 Frameshift.
BK006945 Genomic DNA Translation: DAA09337.1
PIRiS64841
RefSeqiNP_013119.1, NM_001181906.1

Genome annotation databases

EnsemblFungiiYLR019W; YLR019W; YLR019W
GeneIDi850706
KEGGisce:YLR019W

Similar proteinsi

Entry informationi

Entry nameiPSR2_YEAST
AccessioniPrimary (citable) accession number: Q07949
Secondary accession number(s): D6VY21, Q06898, Q6B1J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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