Reviewed,
UniProtKB/Swiss-Prot Q07936 (ANXA2_RAT)
Last modified
November 24, 2009.
Version 101.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Annexin A2 Alternative name(s): Annexin-2 Annexin II Lipocortin II Calpactin I heavy chain Chromobindin-8 p36 Protein I Placental anticoagulant protein IV Short name=PAP-IV | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 339 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. |
| Subunit structure | Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity. |
| Subcellular location | Secreted › extracellular space › extracellular matrix › basement membrane. Melanosome By similarity. Note: In the lamina beneath the plasma membrane. |
| Domain | A pair of annexin repeats may form one binding site for calcium and phospholipid. |
| Miscellaneous | It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. |
| Sequence similarities | Belongs to the annexin family. Contains 4 annexin repeats. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Short (identifier: Q07936-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Long (identifier: Q07936-2) The sequence of this isoform differs from the canonical sequence as follows: 16-16: D → DSQ |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.5 | ||||||
| Chain | 2 – 339 | 338 | Annexin A2 | PRO_0000067473 | |||||
Regions | |||||||||
| Repeat | 42 – 102 | 61 | Annexin 1 | ||||||
| Repeat | 114 – 174 | 61 | Annexin 2 | ||||||
| Repeat | 199 – 259 | 61 | Annexin 3 | ||||||
| Repeat | 274 – 334 | 61 | Annexin 4 | ||||||
| Region | 2 – 24 | 23 | S100A10-binding site Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine Ref.5 | ||||||
| Modified residue | 18 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 19 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 24 | 1 | Phosphotyrosine; by SRC By similarity | ||||||
| Modified residue | 26 | 1 | Phosphoserine; by PKC By similarity | ||||||
| Modified residue | 30 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 104 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 115 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 148 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 152 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 157 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 188 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 199 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 227 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 238 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 275 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 279 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 302 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 313 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 316 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 317 | 1 | Phosphotyrosine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 16 | 1 | D → DSQ in isoform Long. | VSP_000287 | |||||
Experimental info | |||||||||
| Sequence conflict | 103 | 1 | L → F in AAB31934. Ref.3 | ||||||
| Sequence conflict | 103 | 1 | L → F in AAB31933. Ref.3 | ||||||
| Sequence conflict | 322 | 1 | D → Y in AAB31934. Ref.3 | ||||||
| Sequence conflict | 322 | 1 | D → Y in AAB31933. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning of rat calpactin I heavy-chain cDNA whose expression is induced in v-src-transformed rat culture cell lines." Ozaki T., Sakiyama S. Oncogene 8:1707-1710(1993) [PubMed: 8389036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). |
| [2] | Ernst J.D. Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). |
| [3] | "Molecular cloning of a novel N-terminal variant of annexin II from rat basophilic leukaemia cells." Upton A.L., Moss S.E. Biochem. J. 302:425-428(1994) [PubMed: 8092993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT). Tissue: Pituitary. |
| [5] | Bienvenut W.V., von Kriegsheim A., Kolch W. Submitted (JUN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-10; 38-47; 50-63; 69-77; 89-115; 120-145; 158-168; 180-204; 234-245 AND 314-324, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY. Tissue: Fibroblast. |
| [6] | Lubec G., Afjehi-Sadat L., Kang S.U. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 38-47; 50-63; 89-115; 136-145; 158-168; 180-196 AND 314-324 (ISOFORMS SHORT/LONG), MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain and Spinal cord. |
| [7] | "CAP-50, a newly identified annexin, localizes in nuclei of cultured fibroblast 3Y1 cells." Mizutani A., Usuda N., Tokumitsu H., Minami H., Yasui K., Kobayashi R., Hidaka H. J. Biol. Chem. 267:13498-13504(1992) [PubMed: 1618851] [Abstract] Cited for: SUBCELLULAR LOCATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X66871 mRNA. Translation: CAA47343.1. L13039 mRNA. Translation: AAA40741.1. S73559 mRNA. Translation: AAB31934.2. S73557 mRNA. Translation: AAB31933.2. BC059136 mRNA. Translation: AAH59136.1. | |
| IPI | IPI00325146. IPI00829462. |
| PIR | S33700. S55277. |
| RefSeq | NP_063970.1. |
| UniGene | Rn.90546 |
3D structure databases | |
| SMR | Q07936. Positions 21-339. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q07936. |
PTM databases | |
| PhosphoSite | Q07936. |
Proteomic databases | |
| PRIDE | Q07936. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000038677; ENSRNOP00000038428; ENSRNOG00000010362; Rattus norvegicus. [Genome view] |
| GeneID | 56611. |
| KEGG | rno:56611. |
| UCSC | NM_019905. rat. S73557. rat. |
Organism-specific databases | |
| CTD | 56611. |
| RGD | 621170. Anxa2. |
Phylogenomic databases | |
| HOVERGEN | Q07936. |
Gene expression databases | |
| ArrayExpress | Q07936. |
| Genevestigator | Q07936. |
| GermOnline | ENSRNOG00000010362. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR002389. AnnexinII. [Graphical view] |
| Gene3D | G3DSA:1.10.220.10. Annexin. 4 hits. |
| PANTHER | PTHR10502. Annexin. 1 hit. PTHR10502:SF18. AnnexinII. 1 hit. |
| Pfam | PF00191. Annexin. 4 hits. [Graphical view] |
| PRINTS | PR00196. ANNEXIN. PR00198. ANNEXINII. |
| SMART | SM00335. ANX. 4 hits. [Graphical view] |
| PROSITE | PS00223. ANNEXIN. 4 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 611122. |
Entry information
| Entry name | ANXA2_RAT | ||||||||
| Accession | Primary (citable) accession number: Q07936 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


