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Reviewed, UniProtKB/Swiss-Prot Q07936 (ANXA2_RAT)

Last modified November 24, 2009. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Annexin A2
Alternative name(s):
    Annexin-2
    Annexin II
    Lipocortin II
    Calpactin I heavy chain
    Chromobindin-8
    p36
    Protein I
    Placental anticoagulant protein IV
      Short name=PAP-IV
Gene names
Name: Anxa2
Synonyms: Anx2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

Subunit structure

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF By similarity.

Subcellular location

Secreted › extracellular space › extracellular matrix › basement membrane. Melanosome By similarity. Note: In the lamina beneath the plasma membrane.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Short (identifier: Q07936-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Long (identifier: Q07936-2)

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: D → DSQ

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 339338Annexin A2
PRO_0000067473

Regions

Repeat42 – 10261Annexin 1
Repeat114 – 17461Annexin 2
Repeat199 – 25961Annexin 3
Repeat274 – 33461Annexin 4
Region2 – 2423S100A10-binding site Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.5
Modified residue181Phosphoserine By similarity
Modified residue191Phosphothreonine By similarity
Modified residue241Phosphotyrosine; by SRC By similarity
Modified residue261Phosphoserine; by PKC By similarity
Modified residue301Phosphotyrosine By similarity
Modified residue1041N6-acetyllysine By similarity
Modified residue1151N6-acetyllysine By similarity
Modified residue1481N6-acetyllysine By similarity
Modified residue1521N6-acetyllysine By similarity
Modified residue1571N6-acetyllysine By similarity
Modified residue1881Phosphotyrosine By similarity
Modified residue1991Phosphotyrosine By similarity
Modified residue2271N6-acetyllysine By similarity
Modified residue2381Phosphotyrosine By similarity
Modified residue2751Phosphotyrosine By similarity
Modified residue2791N6-acetyllysine By similarity
Modified residue3021N6-acetyllysine By similarity
Modified residue3131N6-acetyllysine By similarity
Modified residue3161Phosphotyrosine By similarity
Modified residue3171Phosphotyrosine By similarity

Natural variations

Alternative sequence161D → DSQ in isoform Long.
VSP_000287

Experimental info

Sequence conflict1031L → F in AAB31934. Ref.3
Sequence conflict1031L → F in AAB31933. Ref.3
Sequence conflict3221D → Y in AAB31934. Ref.3
Sequence conflict3221D → Y in AAB31933. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Isoform Short [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 101E67F50C01CF8B

FASTA33938,678
        10         20         30         40         50         60 
MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAIKTKG VDEVTIVNIL 

        70         80         90        100        110        120 
TNRSNAQRQD IAFAYQRRTK KELPSAMKSA LSGHLETVML GLLKTPAQYD ASELKASMKG 

       130        140        150        160        170        180 
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGEFRKL LVALAKGKRA 

       190        200        210        220        230        240 
EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 

       250        260        270        280        290        300 
LESIRKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 

       310        320        330 
LKIRSEFKRK YGKSLYYFIQ QDTKGDYQKA LLYLCGGDD

« Hide

Isoform Long.

Checksum: B69F20920DAC93ED
Show »

FASTA34138,893

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References

« Hide 'large scale' references
[1]"Molecular cloning of rat calpactin I heavy-chain cDNA whose expression is induced in v-src-transformed rat culture cell lines."
Ozaki T., Sakiyama S.
Oncogene 8:1707-1710(1993) [PubMed: 8389036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
[2]Ernst J.D.
Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
[3]"Molecular cloning of a novel N-terminal variant of annexin II from rat basophilic leukaemia cells."
Upton A.L., Moss S.E.
Biochem. J. 302:425-428(1994) [PubMed: 8092993] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
Tissue: Pituitary.
[5]Bienvenut W.V., von Kriegsheim A., Kolch W.
Submitted (JUN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-10; 38-47; 50-63; 69-77; 89-115; 120-145; 158-168; 180-204; 234-245 AND 314-324, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY.
Tissue: Fibroblast.
[6]Lubec G., Afjehi-Sadat L., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 38-47; 50-63; 89-115; 136-145; 158-168; 180-196 AND 314-324 (ISOFORMS SHORT/LONG), MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain and Spinal cord.
[7]"CAP-50, a newly identified annexin, localizes in nuclei of cultured fibroblast 3Y1 cells."
Mizutani A., Usuda N., Tokumitsu H., Minami H., Yasui K., Kobayashi R., Hidaka H.
J. Biol. Chem. 267:13498-13504(1992) [PubMed: 1618851] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

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Web resources

Protein Spotlight

Red velvet - Issue 86 of September 2007

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Cross-references

Sequence databases

X66871 mRNA. Translation: CAA47343.1.
L13039 mRNA. Translation: AAA40741.1.
S73559 mRNA. Translation: AAB31934.2.
S73557 mRNA. Translation: AAB31933.2.
BC059136 mRNA. Translation: AAH59136.1.
IPIIPI00325146.
IPI00829462.
PIRS33700.
S55277.
RefSeqNP_063970.1.
UniGeneRn.90546

3D structure databases

SMRQ07936. Positions 21-339.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ07936.

PTM databases

PhosphoSiteQ07936.

Proteomic databases

PRIDEQ07936.

Genome annotation databases

EnsemblENSRNOT00000038677; ENSRNOP00000038428; ENSRNOG00000010362; Rattus norvegicus. [Genome view]
GeneID56611.
KEGGrno:56611.
UCSCNM_019905. rat.
S73557. rat.

Organism-specific databases

CTD56611.
RGD621170. Anxa2.

Phylogenomic databases

HOVERGENQ07936.

Gene expression databases

ArrayExpressQ07936.
GenevestigatorQ07936.
GermOnlineENSRNOG00000010362. Rattus norvegicus.

Family and domain databases

InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
Gene3DG3DSA:1.10.220.10. Annexin. 4 hits.
PANTHERPTHR10502. Annexin. 1 hit.
PTHR10502:SF18. AnnexinII. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio611122.

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Entry information

Entry nameANXA2_RAT
AccessionPrimary (citable) accession number: Q07936
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 24, 2009
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents