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Protein

Pre-mRNA leakage protein 1

Gene

PML1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient splicing and pre-mRNA nuclear retention.1 Publication

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • maintenance of RNA location Source: SGD
  • mRNA export from nucleus Source: SGD
  • mRNA splicing, via spliceosome Source: SGD

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-32177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA leakage protein 1
Gene namesi
Name:PML1
Ordered Locus Names:YLR016C
ORF Names:L1591
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR016C.
SGDiS000004006. PML1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584661 – 204Pre-mRNA leakage protein 1Add BLAST204

Proteomic databases

MaxQBiQ07930.
PRIDEiQ07930.

Interactioni

Subunit structurei

Belongs to the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3 and PML1.

Protein-protein interaction databases

BioGridi31290. 105 interactors.
DIPiDIP-2149N.
IntActiQ07930. 10 interactors.
MINTiMINT-556104.
STRINGi4932.YLR016C.

Structurei

Secondary structure

1204
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 41Combined sources4
Helixi61 – 67Combined sources7
Helixi72 – 74Combined sources3
Beta strandi78 – 84Combined sources7
Helixi85 – 90Combined sources6
Beta strandi93 – 97Combined sources5
Beta strandi102 – 108Combined sources7
Beta strandi128 – 131Combined sources4
Beta strandi141 – 148Combined sources8
Beta strandi151 – 158Combined sources8
Beta strandi178 – 180Combined sources3
Beta strandi184 – 190Combined sources7
Helixi192 – 194Combined sources3
Beta strandi197 – 203Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JKDX-ray2.50A/B25-204[»]
2MKCNMR-B22-42[»]
2MY3NMR-B22-42[»]
3ELSX-ray1.80A51-204[»]
3ELVX-ray2.40A/B1-204[»]
5GM6electron microscopy3.50U1-204[»]
5LQWelectron microscopy5.80N1-204[»]
ProteinModelPortaliQ07930.
SMRiQ07930.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ07930.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 172FHAPROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

HOGENOMiHOG000001108.
InParanoidiQ07930.
KOiK13108.
OMAiLESKSAY.
OrthoDBiEOG092C4XK0.

Family and domain databases

InterProiView protein in InterPro
IPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
PfamiView protein in Pfam
PF00498. FHA. 1 hit.
SMARTiView protein in SMART
SM00240. FHA. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiView protein in PROSITE
PS50006. FHA_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q07930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHRRKRPYN TRNYGHDDKK FKSQYIDIMP DFSPSGLLEL ESNNKEGIAL
60 70 80 90 100
KHVEPQDAIS PDNYMDMLGL EARDRTMYEL VIYRKNDKDK GPWKRYDLNG
110 120 130 140 150
RSCYLVGREL GHSLDTDLDD RTEIVVADIG IPEETSSKQH CVIQFRNVRG
160 170 180 190 200
ILKCYVMDLD SSNGTCLNNV VIPGARYIEL RSGDVLTLSE FEEDNDYELI

FMNV
Length:204
Mass (Da):23,654
Last modified:November 1, 1996 - v1
Checksum:iDA39B4465EFFD378
GO

Sequence cautioni

The sequence CAA62157 differs from that shown. Reason: Frameshift at position 180.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15G → A in CAA62157 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90564 Genomic DNA. Translation: CAA62157.1. Frameshift.
Z73188 Genomic DNA. Translation: CAA97538.1.
AY557934 Genomic DNA. Translation: AAS56260.1.
BK006945 Genomic DNA. Translation: DAA09334.1.
PIRiS64838.
RefSeqiNP_013116.1. NM_001181903.1.

Genome annotation databases

EnsemblFungiiYLR016C; YLR016C; YLR016C.
GeneIDi850703.
KEGGisce:YLR016C.

Similar proteinsi

Entry informationi

Entry nameiPML1_YEAST
AccessioniPrimary (citable) accession number: Q07930
Secondary accession number(s): D6VY18, Q06901
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names