Q07921 (TEN1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Telomere length regulation protein TEN1

Alternative name(s):
Protein telomeric pathways with STN1

Gene names

Name:	TEN1
Ordered Locus Names:	YLR010C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a role in telomere length regulation and telomere end protection. Acts as an inhibitor of telomerase loading through its interaction with CDC13. Ref.1
Subunit structure	Interacts with CDC13 and STN1. Ref.1
Subcellular location	Nucleus Potential. Chromosome › telomere Potential.

Ontologies

Keywords
Cellular component	Chromosome Nucleus Telomere
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of telomere maintenance Inferred from mutant phenotype. Source: SGD telomere capping Inferred from mutant phenotype Ref.1. Source: SGD telomere maintenance via telomerase Inferred from mutant phenotype Ref.1. Source: SGD
Cellular component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: IntAct single-stranded telomeric DNA binding Inferred from direct assay. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
STN1	P38960	7	EBI-35131,EBI-18427

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Telomere length regulation protein TEN1		PRO_0000270926

Sequences

	Sequence		Length	Mass (Da)
	Q07921 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 0D8152451821E2CE	FASTA	160	18,605
	10 20 30 40 50 60 MSQLVLDLKC LKDKIATNYD IHNNVYGGNG MEPNIIHPSK RFRIVVRLVD FLFCKSDEEF 70 80 90 100 110 120 IKGFFCQMIV RNLHCLNSTN GAEEMRLYMS ERLFSAHKDD LRLINGQVLD VRIGVWYGIH 130 140 150 160 QSPPIFEIID FKILSRNDVR DFCEFVKSPL GEKFLNISNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13." Grandin N., Damon C., Charbonneau M. EMBO J. 20:1173-1183(2001) [PubMed: 11230140] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH CDC13 AND STN1.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ296344 Genomic DNA. Translation: CAC24568.1. Z73182 Genomic DNA. Translation: CAA97532.1. AY558198 Genomic DNA. Translation: AAS56524.1. BK006945 Genomic DNA. Translation: DAA09328.1.
PIR	S64832.
RefSeq	NP_013110.1. NM_001181897.1.
3D structure databases
ProteinModelPortal	Q07921.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5926N.
IntAct	Q07921. 2 interactions.
STRING	Q07921.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YLR010C; YLR010C; YLR010C.
GeneID	850696.
KEGG	sce:YLR010C.
NMPDR	fig|4932.3.peg.4101.
Organism-specific databases
CYGD	YLR010c.
SGD	S000004000. TEN1.
Phylogenomic databases
OrthoDB	EOG4KPXMT.
Gene expression databases
ArrayExpress	Q07921.
Genevestigator	Q07921.
Family and domain databases
InterPro	IPR024222. Telomere_length/capping_TEN1. [Graphical view]
KO	K11116.
Pfam	PF12658. Ten1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	966725.

Entry information

Entry name

TEN1_YEAST

Accession

Primary (citable) accession number: Q07921
Secondary accession number(s): D6VY12

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program