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Protein

Nuclear receptor subfamily 4 group A member 2

Gene

Nr4a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). May confer liver-specific regulation of delayed-early genes induced later in the G1 phase of regeneration along with HMR.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi260 – 335Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri263 – 283NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri299 – 323NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding Source: RGD
  • DNA binding transcription factor activity Source: RGD
  • nuclear receptor activity Source: RGD
  • protein heterodimerization activity Source: UniProtKB
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • steroid hormone receptor activity Source: InterPro
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to corticotropin-releasing hormone stimulus Source: UniProtKB
  • dopaminergic neuron differentiation Source: UniProtKB
  • fat cell differentiation Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription by RNA polymerase II Source: RGD
  • response to inorganic substance Source: MGI
  • response to insecticide Source: MGI
  • transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 2
Alternative name(s):
NUR-related factor 1
Nuclear orphan receptor HZF-3
Orphan nuclear receptor NURR1
Regenerating liver nuclear receptor 1
Short name:
RNR-1
SL-322
Gene namesi
Name:Nr4a2
Synonyms:Hzf-3, Nurr1, Rnr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3202 Nr4a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537201 – 598Nuclear receptor subfamily 4 group A member 2Add BLAST598

Proteomic databases

PaxDbiQ07917
PRIDEiQ07917

PTM databases

iPTMnetiQ07917
PhosphoSitePlusiQ07917

Expressioni

Tissue specificityi

Shows a ubiquitous distribution in the cerebral cortex, hippocampus, thalamus, amygdala, and midbrain. Expression increases in prenatally stressed adult offspring in the ventral tegmental area, whereas no changes are observed in the substantia nigra area (at protein level). Not expressed in quiescent liver but is rapidly induced following partial hepatectomy and is specific to hepatic growth as it is not induced in other mitogen-treated cells. Expressed at very low levels in the lung, spleen and stomach and at high levels in the brain.1 Publication

Interactioni

Subunit structurei

Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ07917, 1 interactor
STRINGi10116.ENSRNOP00000043812

Structurei

3D structure databases

ProteinModelPortaliQ07917
SMRiQ07917
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini360 – 595NR LBDPROSITE-ProRule annotationAdd BLAST236

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi287 – 314Bipartite nuclear localization signal (NLS1)By similarityAdd BLAST28
Motifi338 – 350Nuclear localization signal (NLS1)By similarityAdd BLAST13
Motifi443 – 452nuclear export sequence (NES1)By similarity10
Motifi568 – 577nuclear export sequence (NES2)By similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 138Gln-richAdd BLAST59
Compositional biasi127 – 233Pro-richAdd BLAST107
Compositional biasi346 – 391Pro-richAdd BLAST46

Domaini

the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding site for coactivators (By similarity).By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri263 – 283NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri299 – 323NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4217 Eukaryota
ENOG410YWNC LUCA
HOGENOMiHOG000230925
HOVERGENiHBG052663
InParanoidiQ07917
KOiK08558
PhylomeDBiQ07917
TreeFamiTF315430

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR003070 Nuc_orph_rcpt
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003073 NURR_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01284 NUCLEARECPTR
PR01287 NURRNUCRCPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q07917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE
60 70 80 90 100
ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY
110 120 130 140 150
QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP STPGFQVQHS PMWDDPGSLH
160 170 180 190 200
NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SRPGTPVSSC QMRFDGPLHV
210 220 230 240 250
PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS
260 270 280 290 300
PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL
310 320 330 340 350
ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK
360 370 380 390 400
SPQDPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT
410 420 430 440 450
QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR
460 470 480 490 500
LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI
510 520 530 540 550
SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN
560 570 580 590
YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
Length:598
Mass (Da):66,622
Last modified:July 15, 1999 - v3
Checksum:i0A54ED59FB70DEA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182R → A in AAA42058 (PubMed:8473329).Curated1
Sequence conflicti182R → P in AAC53315 (PubMed:9221923).Curated1
Sequence conflicti250S → P in AAA42058 (PubMed:8473329).Curated1
Sequence conflicti252P → A in AAC52143 (PubMed:7914660).Curated1
Sequence conflicti362V → G in AAA42058 (PubMed:8473329).Curated1
Sequence conflicti364 – 371LISALVRA → DQCPRQT in AAA42058 (PubMed:8473329).Curated8
Sequence conflicti434D → S in AAA42058 (PubMed:8473329).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01146 mRNA Translation: AAC52143.1
L08595 mRNA Translation: AAA42058.1
U72345 mRNA Translation: AAC53315.1
PIRiI84692
RefSeqiNP_062201.2, NM_019328.3
XP_006234263.1, XM_006234201.3
XP_017447486.1, XM_017591997.1
UniGeneiRn.88129

Genome annotation databases

GeneIDi54278
KEGGirno:54278

Similar proteinsi

Entry informationi

Entry nameiNR4A2_RAT
AccessioniPrimary (citable) accession number: Q07917
Secondary accession number(s): O35865
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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